Mechanical loading stimulates bone angiogenesis through enhancing type H vessel formation and downregulating exosomal miR‐214‐3p from bone marrow‐derived mesenchymal stem cells

Exosomes are important transporters of miRNAs, which play varying roles in the healing of the bone fracture. Angiogenesis is one of such critical events in bone healing, and we previously reported the stimulatory effect of mechanical loading in vessel remodeling. Focusing on type H vessels and exoso...

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Veröffentlicht in:	The FASEB journal 2021-01, Vol.35 (1), p.e21150-n/a
Hauptverfasser:	Wang, Xuetong, Li, Xinle, Li, Jie, Zhai, Lidong, Liu, Daquan, Abdurahman, Abdusami, Zhang, Yifan, Yokota, Hiroki, Zhang, Ping
Format:	Artikel
Sprache:	eng
Schlagworte:	Animals Bone Marrow Cells - metabolism Exosomes - genetics Exosomes - metabolism Female Knee Joint - blood supply Knee Joint - metabolism knee loading Mesenchymal Stem Cells - metabolism Mice MicroRNAs - genetics MicroRNAs - metabolism MiRNA Neovascularization, Physiologic osteoporosis type H vessels vessel remodeling Weight-Bearing
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