MDMA-facilitated cognitive-behavioural conjoint therapy for posttraumatic stress disorder: an uncontrolled trial
Cognitive-behavioural conjoint therapy (CBCT) for PTSD has been shown to improve PTSD, relationship adjustment, and the health and well-being of partners. MDMA (3,4-methylenedioxymethamphetamine) has been used to facilitate an individual therapy for PTSD. This study was an initial test of the safety...
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| Veröffentlicht in: | European journal of psychotraumatology 2020-12, Vol.11 (1), p.1840123-1840123 |
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| creator | Monson, Candice M. Wagner, Anne C. Mithoefer, Ann T. Liebman, Rachel E. Feduccia, Allison A. Jerome, Lisa Yazar-Klosinski, Berra Emerson, Amy Doblin, Rick Mithoefer, Michael C. |
| description | Cognitive-behavioural conjoint therapy (CBCT) for PTSD has been shown to improve PTSD, relationship adjustment, and the health and well-being of partners. MDMA (3,4-methylenedioxymethamphetamine) has been used to facilitate an individual therapy for PTSD. This study was an initial test of the safety, tolerability, and efficacy of MDMA-facilitated CBCT. Six couples with varying levels of baseline relationship satisfaction in which one partner was diagnosed with PTSD participated in a condensed version of the 15-session CBCT protocol delivered over 7 weeks. There were two sessions in which both members of the couple were administered MDMA. All couples completed the treatment protocol, and there were no serious adverse events in either partner. There were significant improvements in clinician-assessed, patient-rated, and partner-rated PTSD symptoms (pre- to post-treatment/follow-up effect sizes ranged from d = 1.85-3.59), as well as patient depression, sleep, emotion regulation, and trauma-related beliefs. In addition, there were significant improvements in patient and partner-rated relationship adjustment and happiness (d =.64-2.79). These results are contextualized in relation to prior results from individual MDMA-facilitated psychotherapy and CBCT for PTSD alone. MDMA holds promise as a facilitator of CBCT to achieve more robust and broad effects on individual and relational functioning in those with PTSD and their partners.
* MDMA was combined with cognitive-behavioural conjoint therapy for PTSD in six couples revealing significant improvements in PTSD, depression, sleep, emotion regulation, trauma beliefs, and relationship satisfaction.* Controlled studies are planned based on these promising results. |
| doi_str_mv | 10.1080/20008198.2020.1840123 |
| format | Article |
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* MDMA was combined with cognitive-behavioural conjoint therapy for PTSD in six couples revealing significant improvements in PTSD, depression, sleep, emotion regulation, trauma beliefs, and relationship satisfaction.* Controlled studies are planned based on these promising results.</description><identifier>ISSN: 2000-8066</identifier><identifier>ISSN: 2000-8198</identifier><identifier>EISSN: 2000-8066</identifier><identifier>DOI: 10.1080/20008198.2020.1840123</identifier><identifier>PMID: 33408811</identifier><language>eng</language><publisher>United States: Taylor & Francis</publisher><subject>cognitive-behavioural ; cognitivo-conductual ; conjoint ; conjunto ; couple ; Ecstasy ; MDMA ; Other ; pareja ; Post traumatic stress disorder ; PTSD ; Short Communication ; TEPT ; terapia ; therapy ; tratamiento ; treatment ; Well being ; 夫妇 ; 治疗 ; 联合 ; 认知行为</subject><ispartof>European journal of psychotraumatology, 2020-12, Vol.11 (1), p.1840123-1840123</ispartof><rights>2020 Informa UK Limited, trading as Taylor & Francis 2020</rights><rights>2020 Informa UK Limited, trading as Taylor & Francis.</rights><rights>2020 Informa UK Limited, trading as Taylor & Francis. This work is licensed under the Creative Commons Attribution – Non-Commercial License http://creativecommons.org/licenses/by-nc/4.0/ (the “License”). Notwithstanding the ProQuest Terms and Conditions, you may use this content in accordance with the terms of the License.</rights><rights>2020 Informa UK Limited, trading as Taylor & Francis 2020 Informa UK Limited, trading as Taylor & Francis</rights><lds50>peer_reviewed</lds50><oa>free_for_read</oa><woscitedreferencessubscribed>false</woscitedreferencessubscribed><citedby>FETCH-LOGICAL-c562t-8f350ce9fed4a982527afd4eb5b11c36d9e2f269d0392499e320eab26154d1be3</citedby><cites>FETCH-LOGICAL-c562t-8f350ce9fed4a982527afd4eb5b11c36d9e2f269d0392499e320eab26154d1be3</cites><orcidid>0000-0001-6209-8750</orcidid></display><links><openurl>$$Topenurl_article</openurl><openurlfulltext>$$Topenurlfull_article</openurlfulltext><thumbnail>$$Tsyndetics_thumb_exl</thumbnail><linktopdf>$$Uhttps://www.ncbi.nlm.nih.gov/pmc/articles/PMC7748057/pdf/$$EPDF$$P50$$Gpubmedcentral$$Hfree_for_read</linktopdf><linktohtml>$$Uhttps://www.ncbi.nlm.nih.gov/pmc/articles/PMC7748057/$$EHTML$$P50$$Gpubmedcentral$$Hfree_for_read</linktohtml><link.rule.ids>230,314,723,776,780,860,881,2096,27479,27901,27902,53766,53768,59116,59117</link.rule.ids><backlink>$$Uhttps://www.ncbi.nlm.nih.gov/pubmed/33408811$$D View this record in MEDLINE/PubMed$$Hfree_for_read</backlink></links><search><creatorcontrib>Monson, Candice M.</creatorcontrib><creatorcontrib>Wagner, Anne C.</creatorcontrib><creatorcontrib>Mithoefer, Ann T.</creatorcontrib><creatorcontrib>Liebman, Rachel E.</creatorcontrib><creatorcontrib>Feduccia, Allison A.</creatorcontrib><creatorcontrib>Jerome, Lisa</creatorcontrib><creatorcontrib>Yazar-Klosinski, Berra</creatorcontrib><creatorcontrib>Emerson, Amy</creatorcontrib><creatorcontrib>Doblin, Rick</creatorcontrib><creatorcontrib>Mithoefer, Michael C.</creatorcontrib><title>MDMA-facilitated cognitive-behavioural conjoint therapy for posttraumatic stress disorder: an uncontrolled trial</title><title>European journal of psychotraumatology</title><addtitle>Eur J Psychotraumatol</addtitle><description>Cognitive-behavioural conjoint therapy (CBCT) for PTSD has been shown to improve PTSD, relationship adjustment, and the health and well-being of partners. MDMA (3,4-methylenedioxymethamphetamine) has been used to facilitate an individual therapy for PTSD. This study was an initial test of the safety, tolerability, and efficacy of MDMA-facilitated CBCT. Six couples with varying levels of baseline relationship satisfaction in which one partner was diagnosed with PTSD participated in a condensed version of the 15-session CBCT protocol delivered over 7 weeks. There were two sessions in which both members of the couple were administered MDMA. All couples completed the treatment protocol, and there were no serious adverse events in either partner. There were significant improvements in clinician-assessed, patient-rated, and partner-rated PTSD symptoms (pre- to post-treatment/follow-up effect sizes ranged from d = 1.85-3.59), as well as patient depression, sleep, emotion regulation, and trauma-related beliefs. In addition, there were significant improvements in patient and partner-rated relationship adjustment and happiness (d =.64-2.79). These results are contextualized in relation to prior results from individual MDMA-facilitated psychotherapy and CBCT for PTSD alone. MDMA holds promise as a facilitator of CBCT to achieve more robust and broad effects on individual and relational functioning in those with PTSD and their partners.
* MDMA was combined with cognitive-behavioural conjoint therapy for PTSD in six couples revealing significant improvements in PTSD, depression, sleep, emotion regulation, trauma beliefs, and relationship satisfaction.* Controlled studies are planned based on these promising results.</description><subject>cognitive-behavioural</subject><subject>cognitivo-conductual</subject><subject>conjoint</subject><subject>conjunto</subject><subject>couple</subject><subject>Ecstasy</subject><subject>MDMA</subject><subject>Other</subject><subject>pareja</subject><subject>Post traumatic stress disorder</subject><subject>PTSD</subject><subject>Short Communication</subject><subject>TEPT</subject><subject>terapia</subject><subject>therapy</subject><subject>tratamiento</subject><subject>treatment</subject><subject>Well being</subject><subject>夫妇</subject><subject>治疗</subject><subject>联合</subject><subject>认知行为</subject><issn>2000-8066</issn><issn>2000-8198</issn><issn>2000-8066</issn><fulltext>true</fulltext><rsrctype>article</rsrctype><creationdate>2020</creationdate><recordtype>article</recordtype><sourceid>0YH</sourceid><sourceid>BENPR</sourceid><sourceid>DOA</sourceid><recordid>eNp9kk1v1DAQhiMEolXpTwBF4sIlxV9JHA6IqnxVasUFztbEHu965Y0X29lq_z1edlu1HJAs2R6_83jGfqvqNSUXlEjynhFCJB3kBSOshKQglPFn1ek-3kjSdc8frU-q85RWZUe6MuTwsjrhXBApKT2tNrefby8bC9p5lyGjqXVYTC67LTYjLmHrwhzBl-i0Cm7KdV5ihM2utiHWm5ByjjCvITtdpxwxpdq4FKLB-KGGqZ6nkphj8L6Qc3TgX1UvLPiE58f5rPr19cvPq-_NzY9v11eXN41uO5YbaXlLNA4WjYBBspb1YI3AsR0p1bwzAzLLusEQPjAxDMgZQRhZR1th6Ij8rLo-cE2AldpEt4a4UwGc-hsIcaEglrI9qt4UOgdB284KLcxIiWXY4jACJ0KMhfXxwNrM4xqNxtIS-CfQpyeTW6pF2Kq-F5K0fQG8OwJi-D1jymrtkkbvYcIwJ8VE31HWt50s0rf_SFflB6byVEVVWu2Z7GhRtQeVjiGliPahGErU3iLq3iJqbxF1tEjJe_O4k4ese0MUwaeDwE3lh9dwF6I3KsPOh2gjTNolxf9_xx-jKsy-</recordid><startdate>20201207</startdate><enddate>20201207</enddate><creator>Monson, Candice M.</creator><creator>Wagner, Anne C.</creator><creator>Mithoefer, Ann T.</creator><creator>Liebman, Rachel E.</creator><creator>Feduccia, Allison A.</creator><creator>Jerome, Lisa</creator><creator>Yazar-Klosinski, Berra</creator><creator>Emerson, Amy</creator><creator>Doblin, Rick</creator><creator>Mithoefer, Michael C.</creator><general>Taylor & Francis</general><general>Taylor & Francis Ltd</general><general>Taylor & Francis Group</general><scope>0YH</scope><scope>NPM</scope><scope>AAYXX</scope><scope>CITATION</scope><scope>3V.</scope><scope>7X7</scope><scope>7XB</scope><scope>88G</scope><scope>8FI</scope><scope>8FJ</scope><scope>8FK</scope><scope>ABUWG</scope><scope>AFKRA</scope><scope>AZQEC</scope><scope>BENPR</scope><scope>CCPQU</scope><scope>DWQXO</scope><scope>FYUFA</scope><scope>GHDGH</scope><scope>GNUQQ</scope><scope>K9.</scope><scope>M0S</scope><scope>M2M</scope><scope>PIMPY</scope><scope>PQEST</scope><scope>PQQKQ</scope><scope>PQUKI</scope><scope>PRINS</scope><scope>PSYQQ</scope><scope>Q9U</scope><scope>7X8</scope><scope>5PM</scope><scope>DOA</scope><orcidid>https://orcid.org/0000-0001-6209-8750</orcidid></search><sort><creationdate>20201207</creationdate><title>MDMA-facilitated cognitive-behavioural conjoint therapy for posttraumatic stress disorder: an uncontrolled trial</title><author>Monson, Candice M. ; Wagner, Anne C. ; Mithoefer, Ann T. ; Liebman, Rachel E. ; Feduccia, Allison A. ; Jerome, Lisa ; Yazar-Klosinski, Berra ; Emerson, Amy ; Doblin, Rick ; Mithoefer, Michael C.</author></sort><facets><frbrtype>5</frbrtype><frbrgroupid>cdi_FETCH-LOGICAL-c562t-8f350ce9fed4a982527afd4eb5b11c36d9e2f269d0392499e320eab26154d1be3</frbrgroupid><rsrctype>articles</rsrctype><prefilter>articles</prefilter><language>eng</language><creationdate>2020</creationdate><topic>cognitive-behavioural</topic><topic>cognitivo-conductual</topic><topic>conjoint</topic><topic>conjunto</topic><topic>couple</topic><topic>Ecstasy</topic><topic>MDMA</topic><topic>Other</topic><topic>pareja</topic><topic>Post traumatic stress disorder</topic><topic>PTSD</topic><topic>Short Communication</topic><topic>TEPT</topic><topic>terapia</topic><topic>therapy</topic><topic>tratamiento</topic><topic>treatment</topic><topic>Well being</topic><topic>夫妇</topic><topic>治疗</topic><topic>联合</topic><topic>认知行为</topic><toplevel>peer_reviewed</toplevel><toplevel>online_resources</toplevel><creatorcontrib>Monson, Candice M.</creatorcontrib><creatorcontrib>Wagner, Anne C.</creatorcontrib><creatorcontrib>Mithoefer, Ann T.</creatorcontrib><creatorcontrib>Liebman, Rachel E.</creatorcontrib><creatorcontrib>Feduccia, Allison A.</creatorcontrib><creatorcontrib>Jerome, Lisa</creatorcontrib><creatorcontrib>Yazar-Klosinski, Berra</creatorcontrib><creatorcontrib>Emerson, Amy</creatorcontrib><creatorcontrib>Doblin, Rick</creatorcontrib><creatorcontrib>Mithoefer, Michael C.</creatorcontrib><collection>Taylor & Francis Open Access</collection><collection>PubMed</collection><collection>CrossRef</collection><collection>ProQuest Central (Corporate)</collection><collection>Health & Medical Collection</collection><collection>ProQuest Central (purchase pre-March 2016)</collection><collection>Psychology Database (Alumni)</collection><collection>Hospital Premium Collection</collection><collection>Hospital Premium Collection (Alumni Edition)</collection><collection>ProQuest Central (Alumni) (purchase pre-March 2016)</collection><collection>ProQuest Central (Alumni Edition)</collection><collection>ProQuest Central UK/Ireland</collection><collection>ProQuest Central Essentials</collection><collection>ProQuest Central</collection><collection>ProQuest One Community College</collection><collection>ProQuest Central Korea</collection><collection>Health Research Premium Collection</collection><collection>Health Research Premium Collection (Alumni)</collection><collection>ProQuest Central Student</collection><collection>ProQuest Health & Medical Complete (Alumni)</collection><collection>Health & Medical Collection (Alumni Edition)</collection><collection>ProQuest Psychology</collection><collection>Publicly Available Content Database</collection><collection>ProQuest One Academic Eastern Edition (DO NOT USE)</collection><collection>ProQuest One Academic</collection><collection>ProQuest One Academic UKI Edition</collection><collection>ProQuest Central China</collection><collection>ProQuest One Psychology</collection><collection>ProQuest Central Basic</collection><collection>MEDLINE - Academic</collection><collection>PubMed Central (Full Participant titles)</collection><collection>DOAJ Directory of Open Access Journals</collection><jtitle>European journal of psychotraumatology</jtitle></facets><delivery><delcategory>Remote Search Resource</delcategory><fulltext>fulltext</fulltext></delivery><addata><au>Monson, Candice M.</au><au>Wagner, Anne C.</au><au>Mithoefer, Ann T.</au><au>Liebman, Rachel E.</au><au>Feduccia, Allison A.</au><au>Jerome, Lisa</au><au>Yazar-Klosinski, Berra</au><au>Emerson, Amy</au><au>Doblin, Rick</au><au>Mithoefer, Michael C.</au><format>journal</format><genre>article</genre><ristype>JOUR</ristype><atitle>MDMA-facilitated cognitive-behavioural conjoint therapy for posttraumatic stress disorder: an uncontrolled trial</atitle><jtitle>European journal of psychotraumatology</jtitle><addtitle>Eur J Psychotraumatol</addtitle><date>2020-12-07</date><risdate>2020</risdate><volume>11</volume><issue>1</issue><spage>1840123</spage><epage>1840123</epage><pages>1840123-1840123</pages><issn>2000-8066</issn><issn>2000-8198</issn><eissn>2000-8066</eissn><abstract>Cognitive-behavioural conjoint therapy (CBCT) for PTSD has been shown to improve PTSD, relationship adjustment, and the health and well-being of partners. MDMA (3,4-methylenedioxymethamphetamine) has been used to facilitate an individual therapy for PTSD. This study was an initial test of the safety, tolerability, and efficacy of MDMA-facilitated CBCT. Six couples with varying levels of baseline relationship satisfaction in which one partner was diagnosed with PTSD participated in a condensed version of the 15-session CBCT protocol delivered over 7 weeks. There were two sessions in which both members of the couple were administered MDMA. All couples completed the treatment protocol, and there were no serious adverse events in either partner. There were significant improvements in clinician-assessed, patient-rated, and partner-rated PTSD symptoms (pre- to post-treatment/follow-up effect sizes ranged from d = 1.85-3.59), as well as patient depression, sleep, emotion regulation, and trauma-related beliefs. In addition, there were significant improvements in patient and partner-rated relationship adjustment and happiness (d =.64-2.79). These results are contextualized in relation to prior results from individual MDMA-facilitated psychotherapy and CBCT for PTSD alone. MDMA holds promise as a facilitator of CBCT to achieve more robust and broad effects on individual and relational functioning in those with PTSD and their partners.
* MDMA was combined with cognitive-behavioural conjoint therapy for PTSD in six couples revealing significant improvements in PTSD, depression, sleep, emotion regulation, trauma beliefs, and relationship satisfaction.* Controlled studies are planned based on these promising results.</abstract><cop>United States</cop><pub>Taylor & Francis</pub><pmid>33408811</pmid><doi>10.1080/20008198.2020.1840123</doi><tpages>1</tpages><orcidid>https://orcid.org/0000-0001-6209-8750</orcidid><oa>free_for_read</oa></addata></record> |
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| subjects | cognitive-behavioural cognitivo-conductual conjoint conjunto couple Ecstasy MDMA Other pareja Post traumatic stress disorder PTSD Short Communication TEPT terapia therapy tratamiento treatment Well being 夫妇 治疗 联合 认知行为 |
| title | MDMA-facilitated cognitive-behavioural conjoint therapy for posttraumatic stress disorder: an uncontrolled trial |
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