Protein sumoylation with SUMO1 promoted by Pin1 in glioma stem cells augments glioblastoma malignancy

Abstract Background The tumorigenic potential of glioma stem cells (GSCs) is associated with multiple reversible molecular alternations, but the role of posttranslational protein sumoylation in GSCs has not been elucidated. The development of GSC-targeting drugs relies on the discovery of GSC-prefer...

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Veröffentlicht in:	Neuro-oncology (Charlottesville, Va.) Va.), 2020-12, Vol.22 (12), p.1809-1821
Hauptverfasser:	Zhang, Aili, Tao, Weiwei, Zhai, Kui, Fang, Xiaoguang, Huang, Zhi, Yu, Jennifer S, Sloan, Andrew E, Rich, Jeremy N, Zhou, Wenchao, Bao, Shideng
Format:	Artikel
Sprache:	eng
Schlagworte:	Basic and Translational Investigations Brain Neoplasms Glioblastoma Glioma Humans Neoplastic Stem Cells NIMA-Interacting Peptidylprolyl Isomerase - genetics Signal Transduction SUMO-1 Protein Sumoylation
Online-Zugang:	Volltext
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