Inhibition of SETMAR–H3K36me2–NHEJ repair axis in residual disease cells prevents glioblastoma recurrence

Abstract Background Residual disease of glioblastoma (GBM) causes recurrence. However, targeting residual cells has failed, due to their inaccessibility and our lack of understanding of their survival mechanisms to radiation therapy. Here we deciphered a residual cell–specific survival mechanism ess...

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Veröffentlicht in:	Neuro-oncology (Charlottesville, Va.) Va.), 2020-12, Vol.22 (12), p.1785-1796
Hauptverfasser:	Kaur, Ekjot, Nair, Jyothi, Ghorai, Atanu, Mishra, Saket V, Achareker, Anagha, Ketkar, Madhura, Sarkar, Debashmita, Salunkhe, Sameer, Rajendra, Jacinth, Gardi, Nilesh, Desai, Sanket, Iyer, Prajish, Thorat, Rahul, Dutt, Amit, Moiyadi, Aliasgar, Dutt, Shilpee
Format:	Artikel
Sprache:	eng
Schlagworte:	Animals Basic and Translational Investigations DNA Repair Glioblastoma - genetics Histone-Lysine N-Methyltransferase - genetics Histone-Lysine N-Methyltransferase - metabolism Humans Mice Mutation Neoplasm Recurrence, Local - genetics
Online-Zugang:	Volltext
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