Dual and Opposite Roles of Reactive Oxygen Species (ROS) in Chagas Disease: Beneficial on the Pathogen and Harmful on the Host

Chagas disease is a neglected tropical disease, which affects an estimate of 6-7 million people worldwide. Chagas disease is caused by Trypanosoma cruzi, which is a eukaryotic flagellate unicellular organism. At the primary infection sites, these parasites are phagocytized by macrophages, which prod...

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Veröffentlicht in:	Oxidative medicine and cellular longevity 2020, Vol.2020 (2020), p.1-17
Hauptverfasser:	Miralles, Vicente, Morales, Sebastian, Rojas, Diego A., Maldonado, Edio, Solari, Aldo
Format:	Artikel
Sprache:	eng
Schlagworte:	Animals Antioxidants Chagas disease Chagas Disease - metabolism Chagas Disease - pathology Chronic Disease Deoxyribonucleic acid DNA Endoplasmic reticulum Enzymes Humans Infections Macrophages - metabolism Macrophages - parasitology Macrophages - pathology Mitochondrial DNA Myocytes, Cardiac - metabolism Myocytes, Cardiac - parasitology Myocytes, Cardiac - pathology Oxidation-Reduction Parasites Protozoa Reactive Nitrogen Species - metabolism Reactive oxygen species Reactive Oxygen Species - metabolism Review Tropical diseases Trypanosoma cruzi - metabolism
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