Alcohol use and tuberculosis clinical presentation at the time of diagnosis in Puducherry and Tamil Nadu, India
Alcohol use increases the risk of tuberculosis (TB) disease and is associated with worse outcomes. To determine whether alcohol use affects TB severity at diagnosis in a high-burden setting. Participants were smear-positive people living with TB (PLWTB) in India. Disease severity was assessed as 1)...
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| creator | Kan, Carolyn K Ragan, Elizabeth J Sarkar, Sonali Knudsen, Selby Forsyth, Megan Muthuraj, Muthaiah Vinod, Kumar Jenkins, Helen E Horsburgh, C Robert Salgame, Padmini Roy, Gautam Ellner, Jerrold J Jacobson, Karen R Sahu, Swaroop Hochberg, Natasha S |
| description | Alcohol use increases the risk of tuberculosis (TB) disease and is associated with worse outcomes.
To determine whether alcohol use affects TB severity at diagnosis in a high-burden setting.
Participants were smear-positive people living with TB (PLWTB) in India. Disease severity was assessed as 1) high versus low smear grade, 2) time to positivity (TTP) on liquid culture, 3) chest radiograph cavitation, and 4) percent lung affected. Alcohol use and being at-risk for alcohol use disorders (AUD) were assessed using the AUDIT-C. Univariable and multivariable analyses were conducted.
Of 1166 PLWTB, 691 (59.3%) were drinkers; of those, 518/691 (75.0%) were at-risk for AUD. Drinkers had more lung affected than non-drinkers (adjusted mean difference 10.8%, p |
| doi_str_mv | 10.1371/journal.pone.0240595 |
| format | Article |
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To determine whether alcohol use affects TB severity at diagnosis in a high-burden setting.
Participants were smear-positive people living with TB (PLWTB) in India. Disease severity was assessed as 1) high versus low smear grade, 2) time to positivity (TTP) on liquid culture, 3) chest radiograph cavitation, and 4) percent lung affected. Alcohol use and being at-risk for alcohol use disorders (AUD) were assessed using the AUDIT-C. Univariable and multivariable analyses were conducted.
Of 1166 PLWTB, 691 (59.3%) were drinkers; of those, 518/691 (75.0%) were at-risk for AUD. Drinkers had more lung affected than non-drinkers (adjusted mean difference 10.8%, p<0.0001); this was not significant for those at-risk for AUD (adjusted mean difference 3.7%, p = 0.11). High smear grade (aOR 1.0, 95%CI: 0.7-1.4), cavitation (aOR 0.8, 95%CI 0.4-1.8), and TTP (mean difference 5.2 hours, p = 0.51) did not differ between drinkers and non-drinkers, nor between those at-risk and not at-risk for AUD.
A large proportion of PLWTB were drinkers and were at-risk for AUD. Alcohol drinkers had more lung affected than non-drinkers. Studies are needed to explore mechanisms of this association.</description><identifier>ISSN: 1932-6203</identifier><identifier>EISSN: 1932-6203</identifier><identifier>DOI: 10.1371/journal.pone.0240595</identifier><identifier>PMID: 33332367</identifier><language>eng</language><publisher>United States: Public Library of Science</publisher><subject>Adolescent ; Adult ; Age ; Alcohol Drinking - adverse effects ; Alcohol Drinking - epidemiology ; Alcohol use ; Alcoholism - complications ; Alcoholism - epidemiology ; Alcohols ; Authorship ; Biology and Life Sciences ; Cavitation ; Diabetes ; Diagnosis ; Disease prevention ; Drinking of alcoholic beverages ; Female ; Health aspects ; Health risks ; Humans ; India ; Infectious diseases ; Liquid culture ; Lung - diagnostic imaging ; Lungs ; Male ; Medical diagnosis ; Medical education ; Medicine ; Medicine and Health Sciences ; Middle Aged ; Mycobacterium tuberculosis - isolation & purification ; Per capita ; Prospective Studies ; Public health ; Radiographs ; Radiography ; Risk ; Risk Factors ; Severity of Illness Index ; Social Sciences ; Tuberculosis ; Tuberculosis, Pulmonary - diagnosis ; Tuberculosis, Pulmonary - epidemiology ; Tuberculosis, Pulmonary - microbiology ; Young Adult</subject><ispartof>PloS one, 2020-12, Vol.15 (12), p.e0240595</ispartof><rights>COPYRIGHT 2020 Public Library of Science</rights><rights>2020 Kan et al. This is an open access article distributed under the terms of the Creative Commons Attribution License: http://creativecommons.org/licenses/by/4.0/ (the “License”), which permits unrestricted use, distribution, and reproduction in any medium, provided the original author and source are credited. Notwithstanding the ProQuest Terms and Conditions, you may use this content in accordance with the terms of the License.</rights><rights>2020 Kan et al 2020 Kan et al</rights><lds50>peer_reviewed</lds50><oa>free_for_read</oa><woscitedreferencessubscribed>false</woscitedreferencessubscribed><citedby>FETCH-LOGICAL-c692t-eabd45d33c619515a887f2970748e2cb4435dcb05b69bcc0b5b0d7976c03a4983</citedby><cites>FETCH-LOGICAL-c692t-eabd45d33c619515a887f2970748e2cb4435dcb05b69bcc0b5b0d7976c03a4983</cites><orcidid>0000-0002-6895-931X ; 0000-0002-5449-9973</orcidid></display><links><openurl>$$Topenurl_article</openurl><openurlfulltext>$$Topenurlfull_article</openurlfulltext><thumbnail>$$Tsyndetics_thumb_exl</thumbnail><linktopdf>$$Uhttps://www.ncbi.nlm.nih.gov/pmc/articles/PMC7746146/pdf/$$EPDF$$P50$$Gpubmedcentral$$Hfree_for_read</linktopdf><linktohtml>$$Uhttps://www.ncbi.nlm.nih.gov/pmc/articles/PMC7746146/$$EHTML$$P50$$Gpubmedcentral$$Hfree_for_read</linktohtml><link.rule.ids>230,314,723,776,780,860,881,2096,2915,23845,27901,27902,53766,53768,79343,79344</link.rule.ids><backlink>$$Uhttps://www.ncbi.nlm.nih.gov/pubmed/33332367$$D View this record in MEDLINE/PubMed$$Hfree_for_read</backlink></links><search><creatorcontrib>Kan, Carolyn K</creatorcontrib><creatorcontrib>Ragan, Elizabeth J</creatorcontrib><creatorcontrib>Sarkar, Sonali</creatorcontrib><creatorcontrib>Knudsen, Selby</creatorcontrib><creatorcontrib>Forsyth, Megan</creatorcontrib><creatorcontrib>Muthuraj, Muthaiah</creatorcontrib><creatorcontrib>Vinod, Kumar</creatorcontrib><creatorcontrib>Jenkins, Helen E</creatorcontrib><creatorcontrib>Horsburgh, C Robert</creatorcontrib><creatorcontrib>Salgame, Padmini</creatorcontrib><creatorcontrib>Roy, Gautam</creatorcontrib><creatorcontrib>Ellner, Jerrold J</creatorcontrib><creatorcontrib>Jacobson, Karen R</creatorcontrib><creatorcontrib>Sahu, Swaroop</creatorcontrib><creatorcontrib>Hochberg, Natasha S</creatorcontrib><title>Alcohol use and tuberculosis clinical presentation at the time of diagnosis in Puducherry and Tamil Nadu, India</title><title>PloS one</title><addtitle>PLoS One</addtitle><description>Alcohol use increases the risk of tuberculosis (TB) disease and is associated with worse outcomes.
To determine whether alcohol use affects TB severity at diagnosis in a high-burden setting.
Participants were smear-positive people living with TB (PLWTB) in India. Disease severity was assessed as 1) high versus low smear grade, 2) time to positivity (TTP) on liquid culture, 3) chest radiograph cavitation, and 4) percent lung affected. Alcohol use and being at-risk for alcohol use disorders (AUD) were assessed using the AUDIT-C. Univariable and multivariable analyses were conducted.
Of 1166 PLWTB, 691 (59.3%) were drinkers; of those, 518/691 (75.0%) were at-risk for AUD. Drinkers had more lung affected than non-drinkers (adjusted mean difference 10.8%, p<0.0001); this was not significant for those at-risk for AUD (adjusted mean difference 3.7%, p = 0.11). High smear grade (aOR 1.0, 95%CI: 0.7-1.4), cavitation (aOR 0.8, 95%CI 0.4-1.8), and TTP (mean difference 5.2 hours, p = 0.51) did not differ between drinkers and non-drinkers, nor between those at-risk and not at-risk for AUD.
A large proportion of PLWTB were drinkers and were at-risk for AUD. Alcohol drinkers had more lung affected than non-drinkers. Studies are needed to explore mechanisms of this association.</description><subject>Adolescent</subject><subject>Adult</subject><subject>Age</subject><subject>Alcohol Drinking - adverse effects</subject><subject>Alcohol Drinking - epidemiology</subject><subject>Alcohol use</subject><subject>Alcoholism - complications</subject><subject>Alcoholism - epidemiology</subject><subject>Alcohols</subject><subject>Authorship</subject><subject>Biology and Life Sciences</subject><subject>Cavitation</subject><subject>Diabetes</subject><subject>Diagnosis</subject><subject>Disease prevention</subject><subject>Drinking of alcoholic beverages</subject><subject>Female</subject><subject>Health aspects</subject><subject>Health risks</subject><subject>Humans</subject><subject>India</subject><subject>Infectious diseases</subject><subject>Liquid culture</subject><subject>Lung - diagnostic imaging</subject><subject>Lungs</subject><subject>Male</subject><subject>Medical diagnosis</subject><subject>Medical education</subject><subject>Medicine</subject><subject>Medicine and Health Sciences</subject><subject>Middle Aged</subject><subject>Mycobacterium tuberculosis - isolation & purification</subject><subject>Per capita</subject><subject>Prospective Studies</subject><subject>Public health</subject><subject>Radiographs</subject><subject>Radiography</subject><subject>Risk</subject><subject>Risk Factors</subject><subject>Severity of Illness Index</subject><subject>Social Sciences</subject><subject>Tuberculosis</subject><subject>Tuberculosis, Pulmonary - diagnosis</subject><subject>Tuberculosis, Pulmonary - epidemiology</subject><subject>Tuberculosis, Pulmonary - microbiology</subject><subject>Young Adult</subject><issn>1932-6203</issn><issn>1932-6203</issn><fulltext>true</fulltext><rsrctype>article</rsrctype><creationdate>2020</creationdate><recordtype>article</recordtype><sourceid>EIF</sourceid><sourceid>BENPR</sourceid><sourceid>DOA</sourceid><recordid>eNqNkl-L1DAUxYso7rr6DUQDgiA4Y9qkSfsiDIt_BhZXdPU13CbpNEvazCapuN_ezEx3mYKCyUNC-rsnN6cny57neJkTnr-7dqMfwC63btBLXFBc1uWD7DSvSbFgBSYPj_Yn2ZMQrjEuScXY4-yEpFEQxk8zt7LSdc6iMWgEg0JxbLSXo3XBBCStGYwEi7ZeBz1EiMYNCCKKnUbR9Bq5FikDm2GPmwF9HdUoO-397V7tCnpj0RdQ41u0HhL5NHvUgg362bSeZT8-frg6_7y4uPy0Pl9dLCSri7jQ0ChaKkIky-syL6GqeFvUHHNa6UI2lJJSyQaXDasbKXFTNljxmjOJCdC6ImfZy4PuNr1ETF4FUVCOa1xhxhKxPhDKwbXYetODvxUOjNgfOL8R4KORVouCKd0STBrGNQVWQsMp4FoXFVApS5603k-3jU2vlUxWebAz0fmXwXRi434JzinL6a6ZV5OAdzejDvEfLU_UBlJXZmhdEpO9CVKsGE0_t6hYnqjlX6g0le6NTGlpTTqfFbyZFSQm6t9xA2MIYv392_-zlz_n7OsjttNgYxecHXchCnOQHkDpXQhet_fO5Vjswn7nhtiFXUxhT2Uvjl2_L7pLN_kDvkn6Rg</recordid><startdate>20201217</startdate><enddate>20201217</enddate><creator>Kan, Carolyn K</creator><creator>Ragan, Elizabeth J</creator><creator>Sarkar, Sonali</creator><creator>Knudsen, Selby</creator><creator>Forsyth, Megan</creator><creator>Muthuraj, Muthaiah</creator><creator>Vinod, Kumar</creator><creator>Jenkins, Helen E</creator><creator>Horsburgh, C Robert</creator><creator>Salgame, Padmini</creator><creator>Roy, Gautam</creator><creator>Ellner, Jerrold J</creator><creator>Jacobson, Karen R</creator><creator>Sahu, Swaroop</creator><creator>Hochberg, Natasha S</creator><general>Public Library of Science</general><general>Public Library of Science (PLoS)</general><scope>CGR</scope><scope>CUY</scope><scope>CVF</scope><scope>ECM</scope><scope>EIF</scope><scope>NPM</scope><scope>AAYXX</scope><scope>CITATION</scope><scope>IOV</scope><scope>ISR</scope><scope>3V.</scope><scope>7QG</scope><scope>7QL</scope><scope>7QO</scope><scope>7RV</scope><scope>7SN</scope><scope>7SS</scope><scope>7T5</scope><scope>7TG</scope><scope>7TM</scope><scope>7U9</scope><scope>7X2</scope><scope>7X7</scope><scope>7XB</scope><scope>88E</scope><scope>8AO</scope><scope>8C1</scope><scope>8FD</scope><scope>8FE</scope><scope>8FG</scope><scope>8FH</scope><scope>8FI</scope><scope>8FJ</scope><scope>8FK</scope><scope>ABJCF</scope><scope>ABUWG</scope><scope>AEUYN</scope><scope>AFKRA</scope><scope>ARAPS</scope><scope>ATCPS</scope><scope>AZQEC</scope><scope>BBNVY</scope><scope>BENPR</scope><scope>BGLVJ</scope><scope>BHPHI</scope><scope>C1K</scope><scope>CCPQU</scope><scope>D1I</scope><scope>DWQXO</scope><scope>FR3</scope><scope>FYUFA</scope><scope>GHDGH</scope><scope>GNUQQ</scope><scope>H94</scope><scope>HCIFZ</scope><scope>K9.</scope><scope>KB.</scope><scope>KB0</scope><scope>KL.</scope><scope>L6V</scope><scope>LK8</scope><scope>M0K</scope><scope>M0S</scope><scope>M1P</scope><scope>M7N</scope><scope>M7P</scope><scope>M7S</scope><scope>NAPCQ</scope><scope>P5Z</scope><scope>P62</scope><scope>P64</scope><scope>PATMY</scope><scope>PDBOC</scope><scope>PIMPY</scope><scope>PQEST</scope><scope>PQQKQ</scope><scope>PQUKI</scope><scope>PRINS</scope><scope>PTHSS</scope><scope>PYCSY</scope><scope>RC3</scope><scope>5PM</scope><scope>DOA</scope><orcidid>https://orcid.org/0000-0002-6895-931X</orcidid><orcidid>https://orcid.org/0000-0002-5449-9973</orcidid></search><sort><creationdate>20201217</creationdate><title>Alcohol use and tuberculosis clinical presentation at the time of diagnosis in Puducherry and Tamil Nadu, India</title><author>Kan, Carolyn K ; Ragan, Elizabeth J ; Sarkar, Sonali ; Knudsen, Selby ; Forsyth, Megan ; Muthuraj, Muthaiah ; Vinod, Kumar ; Jenkins, Helen E ; Horsburgh, C Robert ; Salgame, Padmini ; Roy, Gautam ; Ellner, Jerrold J ; Jacobson, Karen R ; Sahu, Swaroop ; Hochberg, Natasha S</author></sort><facets><frbrtype>5</frbrtype><frbrgroupid>cdi_FETCH-LOGICAL-c692t-eabd45d33c619515a887f2970748e2cb4435dcb05b69bcc0b5b0d7976c03a4983</frbrgroupid><rsrctype>articles</rsrctype><prefilter>articles</prefilter><language>eng</language><creationdate>2020</creationdate><topic>Adolescent</topic><topic>Adult</topic><topic>Age</topic><topic>Alcohol Drinking - 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To determine whether alcohol use affects TB severity at diagnosis in a high-burden setting.
Participants were smear-positive people living with TB (PLWTB) in India. Disease severity was assessed as 1) high versus low smear grade, 2) time to positivity (TTP) on liquid culture, 3) chest radiograph cavitation, and 4) percent lung affected. Alcohol use and being at-risk for alcohol use disorders (AUD) were assessed using the AUDIT-C. Univariable and multivariable analyses were conducted.
Of 1166 PLWTB, 691 (59.3%) were drinkers; of those, 518/691 (75.0%) were at-risk for AUD. Drinkers had more lung affected than non-drinkers (adjusted mean difference 10.8%, p<0.0001); this was not significant for those at-risk for AUD (adjusted mean difference 3.7%, p = 0.11). High smear grade (aOR 1.0, 95%CI: 0.7-1.4), cavitation (aOR 0.8, 95%CI 0.4-1.8), and TTP (mean difference 5.2 hours, p = 0.51) did not differ between drinkers and non-drinkers, nor between those at-risk and not at-risk for AUD.
A large proportion of PLWTB were drinkers and were at-risk for AUD. Alcohol drinkers had more lung affected than non-drinkers. Studies are needed to explore mechanisms of this association.</abstract><cop>United States</cop><pub>Public Library of Science</pub><pmid>33332367</pmid><doi>10.1371/journal.pone.0240595</doi><tpages>e0240595</tpages><orcidid>https://orcid.org/0000-0002-6895-931X</orcidid><orcidid>https://orcid.org/0000-0002-5449-9973</orcidid><oa>free_for_read</oa></addata></record> |
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| recordid | cdi_pubmedcentral_primary_oai_pubmedcentral_nih_gov_7746146 |
| source | PubMed (Medline); MEDLINE; Public Library of Science; DOAJ (Directory of Open Access Journals); Free Full-Text Journals in Chemistry; EZB Electronic Journals Library |
| subjects | Adolescent Adult Age Alcohol Drinking - adverse effects Alcohol Drinking - epidemiology Alcohol use Alcoholism - complications Alcoholism - epidemiology Alcohols Authorship Biology and Life Sciences Cavitation Diabetes Diagnosis Disease prevention Drinking of alcoholic beverages Female Health aspects Health risks Humans India Infectious diseases Liquid culture Lung - diagnostic imaging Lungs Male Medical diagnosis Medical education Medicine Medicine and Health Sciences Middle Aged Mycobacterium tuberculosis - isolation & purification Per capita Prospective Studies Public health Radiographs Radiography Risk Risk Factors Severity of Illness Index Social Sciences Tuberculosis Tuberculosis, Pulmonary - diagnosis Tuberculosis, Pulmonary - epidemiology Tuberculosis, Pulmonary - microbiology Young Adult |
| title | Alcohol use and tuberculosis clinical presentation at the time of diagnosis in Puducherry and Tamil Nadu, India |
| url | https://sfx.bib-bvb.de/sfx_tum?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&ctx_tim=2025-02-01T12%3A38%3A06IST&url_ver=Z39.88-2004&url_ctx_fmt=infofi/fmt:kev:mtx:ctx&rfr_id=info:sid/primo.exlibrisgroup.com:primo3-Article-gale_plos_&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.atitle=Alcohol%20use%20and%20tuberculosis%20clinical%20presentation%20at%20the%20time%20of%20diagnosis%20in%20Puducherry%20and%20Tamil%20Nadu,%20India&rft.jtitle=PloS%20one&rft.au=Kan,%20Carolyn%20K&rft.date=2020-12-17&rft.volume=15&rft.issue=12&rft.spage=e0240595&rft.pages=e0240595-&rft.issn=1932-6203&rft.eissn=1932-6203&rft_id=info:doi/10.1371/journal.pone.0240595&rft_dat=%3Cgale_plos_%3EA645382861%3C/gale_plos_%3E%3Curl%3E%3C/url%3E&disable_directlink=true&sfx.directlink=off&sfx.report_link=0&rft_id=info:oai/&rft_pqid=2470908066&rft_id=info:pmid/33332367&rft_galeid=A645382861&rft_doaj_id=oai_doaj_org_article_26def303b67e4a65ab74a09e28a4cc57&rfr_iscdi=true |