KATP Channel Openers Inhibit Lymphatic Contractions and Lymph Flow as a Possible Mechanism of Peripheral Edema

Pharmacological openers of ATP-sensitive potassium (KATP) channels are effective antihypertensive agents, but off-target effects, including severe peripheral edema, limit their clinical usefulness. It is presumed that the arterial dilation induced by KATP channel openers (KCOs) increases capillary p...

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Veröffentlicht in:	The Journal of pharmacology and experimental therapeutics 2021-01, Vol.376 (1), p.40-50
Hauptverfasser:	Garner, Brittney R., Stolarz, Amanda J., Stuckey, Daniel, Sarimollaoglu, Mustafa, Liu, Yunmeng, Palade, Philip T., Rusch, Nancy J., Mu, Shengyu
Format:	Artikel
Sprache:	eng
Schlagworte:	Cardiovascular
Online-Zugang:	Volltext
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