Sources of Multidrug Resistance in Patients With Previous Isoniazid-Resistant Tuberculosis Identified Using Whole Genome Sequencing: A Longitudinal Cohort Study

Abstract Background Meta-analysis of patients with isoniazid-resistant tuberculosis (TB) given standard first-line anti-TB treatment indicated an increased risk of multidrug-resistant TB (MDR-TB) emerging (8%), compared to drug-sensitive TB (0.3%). Here we use whole genome sequencing (WGS) to invest...

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Veröffentlicht in:	Clinical infectious diseases 2020-12, Vol.71 (10), p.e532-e539
Hauptverfasser:	Srinivasan, Vijay, Ha, Vu T N, Vinh, Dao N, Thai, Phan V K, Ha, Dang T M, Lan, Nguyen H, Hai, Hoang T, Walker, Timothy M, Thu, Do D A, Dunstan, Sarah J, Thwaites, Guy E, Ashton, Philip M, Caws, Maxine, Thuong, Nguyen T T
Format:	Artikel
Sprache:	eng
Schlagworte:	Antitubercular Agents - pharmacology Antitubercular Agents - therapeutic use Humans Isoniazid - pharmacology Longitudinal Studies Microbial Sensitivity Tests Mycobacterium tuberculosis - genetics Online Only Tuberculosis, Multidrug-Resistant - drug therapy Tuberculosis, Multidrug-Resistant - epidemiology Whole Genome Sequencing
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