Investigation of the safety and feasibility of AAV1/SERCA2a gene transfer in patients with chronic heart failure supported with a left ventricular assist device – the SERCA-LVAD TRIAL

The SERCA-LVAD trial was a phase 2a trial assessing the safety and feasibility of delivering an adeno-associated vector 1 carrying the cardiac isoform of the sarcoplasmic reticulum calcium ATPase (AAV1/SERCA2a) to adult chronic heart failure patients implanted with a left ventricular assist device....

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Veröffentlicht in:	Gene therapy 2020-12, Vol.27 (12), p.579-590
Hauptverfasser:	Lyon, A. R., Babalis, D., Morley-Smith, A. C., Hedger, M., Suarez Barrientos, A., Foldes, G., Couch, L. S., Chowdhury, R. A., Tzortzis, K. N., Peters, N. S., Rog-Zielinska, E. A., Yang, H-Y, Welch, S., Bowles, C. T., Rahman Haley, S., Bell, A. R., Rice, A., Sasikaran, T., Johnson, N. A., Falaschetti, E., Parameshwar, J., Lewis, C., Tsui, S., Simon, A., Pepper, J., Rudy, J. J., Zsebo, K. M., Macleod, K. T., Terracciano, C. M., Hajjar, R. J., Banner, N., Harding, S. E.
Format:	Artikel
Sprache:	eng
Schlagworte:	42/44 631/61/201 692/699/75 Biomedical and Life Sciences Biomedicine Biopsy Ca2+-transporting ATPase Calcium (reticular) Cardiac muscle Care and treatment Cell Biology Clinical trials Congestive heart failure Deoxyribonuclease Deoxyribonucleic acid Dependoviruses Development and progression DNA Enzyme-linked immunosorbent assay Evaluation Gene Expression Gene Therapy Health aspects Heart failure Heart transplantation Heart transplants Human Genetics Medical protocols Methods Nanotechnology Patient outcomes Safety Sarcoplasmic reticulum Ventricle
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