In vivo studies of glucagon secretion by human islets transplanted in mice

Little is known about regulated glucagon secretion by human islet α-cells compared to insulin secretion from β-cells, despite conclusive evidence of dysfunction in both cell types in diabetes mellitus. Distinct insulins in humans and mice permit in vivo studies of human β-cell regulation after human...

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Veröffentlicht in:	Nature metabolism 2020-06, Vol.2 (6), p.547-557
Hauptverfasser:	Tellez, Krissie, Hang, Yan, Gu, Xueying, Chang, Charles A., Stein, Roland W., Kim, Seung K.
Format:	Artikel
Sprache:	eng
Schlagworte:	13/51 14/19 14/63 42/41 631/443 631/443/319/1557 631/443/319/1642/137/773 631/80 64 64/60 692/163 Adult Animals Biomedical and Life Sciences CRISPR-Cas Systems Diabetes Mellitus, Type 2 - metabolism Female Glucagon - genetics Glucagon - metabolism Glucagon-Secreting Cells - metabolism Glucose Tolerance Test Humans Islets of Langerhans - metabolism Islets of Langerhans Transplantation Life Sciences Liver - metabolism Liver Glycogen - metabolism Male Mice Mice, Knockout Middle Aged
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