Putting the BRK on breast cancer: From molecular target to therapeutics

BReast tumor Kinase (BRK, also known as PTK6) is a non-receptor tyrosine kinase that is highly expressed in breast carcinomas while having low expression in the normal mammary gland, which hints at the oncogenic nature of this kinase in breast cancer. In the past twenty-six years since the discovery...

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Veröffentlicht in:	Theranostics 2021, Vol.11 (3), p.1115-1128
Hauptverfasser:	Ang, Hui Li, Yuan, Yi, Lai, Xianning, Tan, Tuan Zea, Wang, Lingzhi, Huang, Benjamin BoJun, Pandey, Vijay, Huang, Ruby Yun-Ju, Lobie, Peter E, Goh, Boon Cher, Sethi, Gautam, Yap, Celestial T, Chan, Ching Wan, Lee, Soo Chin, Kumar, Alan Prem
Format:	Artikel
Sprache:	eng
Schlagworte:	Apoptosis Breast cancer Epidermal growth factor Insulin-like growth factors Kinases Ligands Localization Medical prognosis Phosphatase Phosphorylation Proteins Review Self sufficiency
Online-Zugang:	Volltext
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