TLR engagement induces ARID3a in human blood hematopoietic progenitors and modulates IFNα production

The DNA binding protein AT-rich interacting domain 3a (ARID3a)22ARID3a, AT-rich interacting domain 3a is expressed in healthy human hematopoietic cord blood progenitors where its modulation influences myeloid versus B lineage development. ARID3a is also variably expressed in subsets of adult periphe...

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Veröffentlicht in:	Cellular immunology 2020-11, Vol.357, p.104201-104201, Article 104201
Hauptverfasser:	Ratliff, Michelle L., Shankar, Malini, Guthridge, Joel M., James, Judith A., Webb, Carol F.
Format:	Artikel
Sprache:	eng
Schlagworte:	Adult ARID3a B-Lymphocytes - cytology B-Lymphocytes - metabolism CpG Islands Cytokines - metabolism DNA-Binding Proteins - antagonists & inhibitors DNA-Binding Proteins - biosynthesis DNA-Binding Proteins - blood Female Flow Cytometry - methods Gene Expression Hematopoiesis Hematopoietic Stem Cells - cytology Hematopoietic Stem Cells - drug effects Hematopoietic Stem Cells - metabolism Humans Innate immunity Interferon-alpha - biosynthesis Interferon-alpha - genetics Interferon-alpha - immunology Ligands Middle Aged Signal Transduction Toll-Like Receptors - blood Transcription Factors - antagonists & inhibitors Transcription Factors - biosynthesis Transcription Factors - blood
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