Prevalence and Risk Factors of Substance Use Disorder in Inflammatory Bowel Disease
Abstract Background Substance use disorders (SUDs) impose a substantial individual and societal burden; however, the prevalence and associated factors in persons with inflammatory bowel disease (IBD) are largely unknown. We evaluated the prevalence and risk factors of SUD in an IBD cohort. Methods I...
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| Veröffentlicht in: | Inflammatory bowel diseases 2021-01, Vol.27 (1), p.58-64 |
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| creator | Carney, Heather Marrie, Ruth Ann Bolton, James M Patten, Scott B Graff, Lesley A Bernstein, Charles N Kowalec, Kaarina |
| description | Abstract
Background
Substance use disorders (SUDs) impose a substantial individual and societal burden; however, the prevalence and associated factors in persons with inflammatory bowel disease (IBD) are largely unknown. We evaluated the prevalence and risk factors of SUD in an IBD cohort.
Methods
Inflammatory bowel disease participants (n = 247) were recruited via hospital- and community-based gastroenterology clinics, a population-based IBD research registry, and primary care providers as part of a larger cohort study of psychiatric comorbidity in immune-mediated inflammatory diseases. The Structured Clinical Interview for Diagnostic and Statistical Manual of Mental Disorders IV was administered to participants to identify lifetime SUD, anxiety disorder, and major depressive disorder. Additional questionnaires regarding participants’ sociodemographic and clinical characteristics were also completed. We examined demographic and clinical factors associated with lifetime SUD using unadjusted and adjusted logistic regression modeling.
Results
Forty-one (16.6%) IBD participants met the criteria for a lifetime diagnosis of an SUD. Factors associated with elevated odds of SUD were ever smoking (adjusted odds ratio [aOR], 2.96; 95% confidence interval [CI], 1.17–7.50), male sex (aOR, 2.44; 95% CI, 1.11–5.36), lifetime anxiety disorder (aOR, 2.41; 95% CI, 1.08–5.37), and higher pain impact (aOR, 1.08; 95% CI, 1.01–1.16).
Conclusions
One in six persons with IBD experienced an SUD, suggesting that clinicians should maintain high index of suspicion regarding possible SUD, and inquiries about substance use should be a part of care for IBD patients, particularly for men, smokers, and patients with anxiety disorders and pain.
Authors evaluated the prevalence and risk factors of SUD in an IBD cohort (n = 247). Forty-one (16.6%) participants experienced a lifetime SUD. Factors associated with elevated odds of SUD were ever smoking, male sex, lifetime anxiety disorder, and higher pain impact. |
| doi_str_mv | 10.1093/ibd/izaa014 |
| format | Article |
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Background
Substance use disorders (SUDs) impose a substantial individual and societal burden; however, the prevalence and associated factors in persons with inflammatory bowel disease (IBD) are largely unknown. We evaluated the prevalence and risk factors of SUD in an IBD cohort.
Methods
Inflammatory bowel disease participants (n = 247) were recruited via hospital- and community-based gastroenterology clinics, a population-based IBD research registry, and primary care providers as part of a larger cohort study of psychiatric comorbidity in immune-mediated inflammatory diseases. The Structured Clinical Interview for Diagnostic and Statistical Manual of Mental Disorders IV was administered to participants to identify lifetime SUD, anxiety disorder, and major depressive disorder. Additional questionnaires regarding participants’ sociodemographic and clinical characteristics were also completed. We examined demographic and clinical factors associated with lifetime SUD using unadjusted and adjusted logistic regression modeling.
Results
Forty-one (16.6%) IBD participants met the criteria for a lifetime diagnosis of an SUD. Factors associated with elevated odds of SUD were ever smoking (adjusted odds ratio [aOR], 2.96; 95% confidence interval [CI], 1.17–7.50), male sex (aOR, 2.44; 95% CI, 1.11–5.36), lifetime anxiety disorder (aOR, 2.41; 95% CI, 1.08–5.37), and higher pain impact (aOR, 1.08; 95% CI, 1.01–1.16).
Conclusions
One in six persons with IBD experienced an SUD, suggesting that clinicians should maintain high index of suspicion regarding possible SUD, and inquiries about substance use should be a part of care for IBD patients, particularly for men, smokers, and patients with anxiety disorders and pain.
Authors evaluated the prevalence and risk factors of SUD in an IBD cohort (n = 247). Forty-one (16.6%) participants experienced a lifetime SUD. Factors associated with elevated odds of SUD were ever smoking, male sex, lifetime anxiety disorder, and higher pain impact.</description><identifier>ISSN: 1078-0998</identifier><identifier>EISSN: 1536-4844</identifier><identifier>DOI: 10.1093/ibd/izaa014</identifier><identifier>PMID: 32025740</identifier><language>eng</language><publisher>US: Oxford University Press</publisher><subject>Anxiety ; Clinical Research ; Comorbidity ; Social aspects ; Substance abuse</subject><ispartof>Inflammatory bowel diseases, 2021-01, Vol.27 (1), p.58-64</ispartof><rights>2020 Crohn’s & Colitis Foundation. Published by Oxford University Press on behalf of Crohn’s & Colitis Foundation. 2020</rights><rights>2020 Crohn’s & Colitis Foundation. Published by Oxford University Press on behalf of Crohn’s & Colitis Foundation.</rights><rights>COPYRIGHT 2021 Oxford University Press</rights><lds50>peer_reviewed</lds50><oa>free_for_read</oa><woscitedreferencessubscribed>false</woscitedreferencessubscribed><citedby>FETCH-LOGICAL-c479t-25d5a32349b6a0654be4e7bd7c9a730cab16f7b428839bfd4ca6ade0397fe7c63</citedby><cites>FETCH-LOGICAL-c479t-25d5a32349b6a0654be4e7bd7c9a730cab16f7b428839bfd4ca6ade0397fe7c63</cites><orcidid>0000-0003-3928-9879</orcidid></display><links><openurl>$$Topenurl_article</openurl><openurlfulltext>$$Topenurlfull_article</openurlfulltext><thumbnail>$$Tsyndetics_thumb_exl</thumbnail><link.rule.ids>230,314,776,780,881,1578,27901,27902</link.rule.ids><backlink>$$Uhttps://www.ncbi.nlm.nih.gov/pubmed/32025740$$D View this record in MEDLINE/PubMed$$Hfree_for_read</backlink></links><search><creatorcontrib>Carney, Heather</creatorcontrib><creatorcontrib>Marrie, Ruth Ann</creatorcontrib><creatorcontrib>Bolton, James M</creatorcontrib><creatorcontrib>Patten, Scott B</creatorcontrib><creatorcontrib>Graff, Lesley A</creatorcontrib><creatorcontrib>Bernstein, Charles N</creatorcontrib><creatorcontrib>Kowalec, Kaarina</creatorcontrib><title>Prevalence and Risk Factors of Substance Use Disorder in Inflammatory Bowel Disease</title><title>Inflammatory bowel diseases</title><addtitle>Inflamm Bowel Dis</addtitle><description>Abstract
Background
Substance use disorders (SUDs) impose a substantial individual and societal burden; however, the prevalence and associated factors in persons with inflammatory bowel disease (IBD) are largely unknown. We evaluated the prevalence and risk factors of SUD in an IBD cohort.
Methods
Inflammatory bowel disease participants (n = 247) were recruited via hospital- and community-based gastroenterology clinics, a population-based IBD research registry, and primary care providers as part of a larger cohort study of psychiatric comorbidity in immune-mediated inflammatory diseases. The Structured Clinical Interview for Diagnostic and Statistical Manual of Mental Disorders IV was administered to participants to identify lifetime SUD, anxiety disorder, and major depressive disorder. Additional questionnaires regarding participants’ sociodemographic and clinical characteristics were also completed. We examined demographic and clinical factors associated with lifetime SUD using unadjusted and adjusted logistic regression modeling.
Results
Forty-one (16.6%) IBD participants met the criteria for a lifetime diagnosis of an SUD. Factors associated with elevated odds of SUD were ever smoking (adjusted odds ratio [aOR], 2.96; 95% confidence interval [CI], 1.17–7.50), male sex (aOR, 2.44; 95% CI, 1.11–5.36), lifetime anxiety disorder (aOR, 2.41; 95% CI, 1.08–5.37), and higher pain impact (aOR, 1.08; 95% CI, 1.01–1.16).
Conclusions
One in six persons with IBD experienced an SUD, suggesting that clinicians should maintain high index of suspicion regarding possible SUD, and inquiries about substance use should be a part of care for IBD patients, particularly for men, smokers, and patients with anxiety disorders and pain.
Authors evaluated the prevalence and risk factors of SUD in an IBD cohort (n = 247). Forty-one (16.6%) participants experienced a lifetime SUD. Factors associated with elevated odds of SUD were ever smoking, male sex, lifetime anxiety disorder, and higher pain impact.</description><subject>Anxiety</subject><subject>Clinical Research</subject><subject>Comorbidity</subject><subject>Social aspects</subject><subject>Substance abuse</subject><issn>1078-0998</issn><issn>1536-4844</issn><fulltext>true</fulltext><rsrctype>article</rsrctype><creationdate>2021</creationdate><recordtype>article</recordtype><sourceid>TOX</sourceid><recordid>eNp9kdFr1TAUxoMobk6ffJeCIIJ0S5u0aV6EOZ0OBopzz-EkOZnRNrkm7WT-9abc63Agch5yyPc7Hyf5CHna0MOGSnbktT3yvwBow--R_aZjfc0Hzu-XnoqhplIOe-RRzt8obUvJh2SPlaYTnO6Ti08Jr2HEYLCCYKvPPn-vTsHMMeUquupi0XmGVb3MWL31OSaLqfKhOgtuhGmCQt5Ub-JPHFcZIeNj8sDBmPHJ7jwgl6fvvpx8qM8_vj87OT6vDRdyrtvOdsBaxqXugfYd18hRaCuMBMGoAd30TmjeDgOT2lluoAeLlEnhUJieHZDXW9_Noie0BsOcYFSb5CdINyqCV3eV4L-qq3ithGCi6XgxeLkzSPHHgnlWk88GxxECxiWrlnUt7XhLRUGfb9Gr8lnKBxeLo1lxddxLMQyc8XWjw39QpSxO3sSAzpf7OwOvtgMmxZwTutvtG6rWdFVJV-3SLfSzvx98y_6JswAvtkBcNv91-g19EK41</recordid><startdate>20210101</startdate><enddate>20210101</enddate><creator>Carney, Heather</creator><creator>Marrie, Ruth Ann</creator><creator>Bolton, James M</creator><creator>Patten, Scott B</creator><creator>Graff, Lesley A</creator><creator>Bernstein, Charles N</creator><creator>Kowalec, Kaarina</creator><general>Oxford University Press</general><scope>TOX</scope><scope>NPM</scope><scope>AAYXX</scope><scope>CITATION</scope><scope>7X8</scope><scope>5PM</scope><orcidid>https://orcid.org/0000-0003-3928-9879</orcidid></search><sort><creationdate>20210101</creationdate><title>Prevalence and Risk Factors of Substance Use Disorder in Inflammatory Bowel Disease</title><author>Carney, Heather ; Marrie, Ruth Ann ; Bolton, James M ; Patten, Scott B ; Graff, Lesley A ; Bernstein, Charles N ; Kowalec, Kaarina</author></sort><facets><frbrtype>5</frbrtype><frbrgroupid>cdi_FETCH-LOGICAL-c479t-25d5a32349b6a0654be4e7bd7c9a730cab16f7b428839bfd4ca6ade0397fe7c63</frbrgroupid><rsrctype>articles</rsrctype><prefilter>articles</prefilter><language>eng</language><creationdate>2021</creationdate><topic>Anxiety</topic><topic>Clinical Research</topic><topic>Comorbidity</topic><topic>Social aspects</topic><topic>Substance abuse</topic><toplevel>peer_reviewed</toplevel><toplevel>online_resources</toplevel><creatorcontrib>Carney, Heather</creatorcontrib><creatorcontrib>Marrie, Ruth Ann</creatorcontrib><creatorcontrib>Bolton, James M</creatorcontrib><creatorcontrib>Patten, Scott B</creatorcontrib><creatorcontrib>Graff, Lesley A</creatorcontrib><creatorcontrib>Bernstein, Charles N</creatorcontrib><creatorcontrib>Kowalec, Kaarina</creatorcontrib><collection>Oxford Journals Open Access Collection</collection><collection>PubMed</collection><collection>CrossRef</collection><collection>MEDLINE - Academic</collection><collection>PubMed Central (Full Participant titles)</collection><jtitle>Inflammatory bowel diseases</jtitle></facets><delivery><delcategory>Remote Search Resource</delcategory><fulltext>fulltext</fulltext></delivery><addata><au>Carney, Heather</au><au>Marrie, Ruth Ann</au><au>Bolton, James M</au><au>Patten, Scott B</au><au>Graff, Lesley A</au><au>Bernstein, Charles N</au><au>Kowalec, Kaarina</au><format>journal</format><genre>article</genre><ristype>JOUR</ristype><atitle>Prevalence and Risk Factors of Substance Use Disorder in Inflammatory Bowel Disease</atitle><jtitle>Inflammatory bowel diseases</jtitle><addtitle>Inflamm Bowel Dis</addtitle><date>2021-01-01</date><risdate>2021</risdate><volume>27</volume><issue>1</issue><spage>58</spage><epage>64</epage><pages>58-64</pages><issn>1078-0998</issn><eissn>1536-4844</eissn><abstract>Abstract
Background
Substance use disorders (SUDs) impose a substantial individual and societal burden; however, the prevalence and associated factors in persons with inflammatory bowel disease (IBD) are largely unknown. We evaluated the prevalence and risk factors of SUD in an IBD cohort.
Methods
Inflammatory bowel disease participants (n = 247) were recruited via hospital- and community-based gastroenterology clinics, a population-based IBD research registry, and primary care providers as part of a larger cohort study of psychiatric comorbidity in immune-mediated inflammatory diseases. The Structured Clinical Interview for Diagnostic and Statistical Manual of Mental Disorders IV was administered to participants to identify lifetime SUD, anxiety disorder, and major depressive disorder. Additional questionnaires regarding participants’ sociodemographic and clinical characteristics were also completed. We examined demographic and clinical factors associated with lifetime SUD using unadjusted and adjusted logistic regression modeling.
Results
Forty-one (16.6%) IBD participants met the criteria for a lifetime diagnosis of an SUD. Factors associated with elevated odds of SUD were ever smoking (adjusted odds ratio [aOR], 2.96; 95% confidence interval [CI], 1.17–7.50), male sex (aOR, 2.44; 95% CI, 1.11–5.36), lifetime anxiety disorder (aOR, 2.41; 95% CI, 1.08–5.37), and higher pain impact (aOR, 1.08; 95% CI, 1.01–1.16).
Conclusions
One in six persons with IBD experienced an SUD, suggesting that clinicians should maintain high index of suspicion regarding possible SUD, and inquiries about substance use should be a part of care for IBD patients, particularly for men, smokers, and patients with anxiety disorders and pain.
Authors evaluated the prevalence and risk factors of SUD in an IBD cohort (n = 247). Forty-one (16.6%) participants experienced a lifetime SUD. Factors associated with elevated odds of SUD were ever smoking, male sex, lifetime anxiety disorder, and higher pain impact.</abstract><cop>US</cop><pub>Oxford University Press</pub><pmid>32025740</pmid><doi>10.1093/ibd/izaa014</doi><tpages>7</tpages><orcidid>https://orcid.org/0000-0003-3928-9879</orcidid><oa>free_for_read</oa></addata></record> |
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| ispartof | Inflammatory bowel diseases, 2021-01, Vol.27 (1), p.58-64 |
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| language | eng |
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| source | Oxford University Press Journals All Titles (1996-Current) |
| subjects | Anxiety Clinical Research Comorbidity Social aspects Substance abuse |
| title | Prevalence and Risk Factors of Substance Use Disorder in Inflammatory Bowel Disease |
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