Genome-wide mapping of SARS-CoV-2 RNA structures identifies therapeutically-relevant elements

Abstract SARS-CoV-2 is a betacoronavirus with a linear single-stranded, positive-sense RNA genome, whose outbreak caused the ongoing COVID-19 pandemic. The ability of coronaviruses to rapidly evolve, adapt, and cross species barriers makes the development of effective and durable therapeutic strateg...

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Veröffentlicht in:	Nucleic acids research 2020-12, Vol.48 (22), p.12436-12452
Hauptverfasser:	Manfredonia, Ilaria, Nithin, Chandran, Ponce-Salvatierra, Almudena, Ghosh, Pritha, Wirecki, Tomasz K, Marinus, Tycho, Ogando, Natacha S, Snijder, Eric J, van Hemert, Martijn J, Bujnicki, Janusz M, Incarnato, Danny
Format:	Artikel
Sprache:	eng
Schlagworte:	5' Untranslated Regions - genetics Algorithms Antiviral Agents - chemistry Antiviral Agents - metabolism Antiviral Agents - therapeutic use Base Sequence Binding Sites - genetics Conserved Sequence - genetics COVID-19 - epidemiology COVID-19 - prevention & control COVID-19 - virology Genome, Viral - genetics Humans Models, Molecular NAR Breakthrough Nucleic Acid Conformation Pandemics RNA, Viral - chemistry SARS-CoV-2 - drug effects SARS-CoV-2 - genetics SARS-CoV-2 - physiology
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