The effect of tropisetron on oxidative stress, SIRT1, FOXO3a, and claudin-1 in the renal tissue of STZ-induced diabetic rats

Tropisetron is a 5-HT3 receptor antagonist that exerts protective effect against DN. The aim of this study was to investigate the possible molecular mechanisms associated with the renoprotective effects of tropisetron in STZ-induced diabetic rats. Animals were subdivided into 5 equal groups; control...

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Veröffentlicht in:	Cell stress & chaperones 2021-01, Vol.26 (1), p.217-227
Hauptverfasser:	Samadi, Mahrokh, Aziz, Shiva Gholizadeh-Ghaleh, Naderi, Roya
Format:	Artikel
Sprache:	eng
Schlagworte:	Animals Biochemistry Biomedical and Life Sciences Biomedicine Cancer Research Cell Biology Claudin-1 - metabolism Diabetes Mellitus, Experimental - drug therapy Diabetes Mellitus, Experimental - metabolism Diabetes Mellitus, Experimental - pathology Diabetic Nephropathies - drug therapy Diabetic Nephropathies - metabolism Diabetic Nephropathies - pathology Forkhead Box Protein O3 - metabolism Immunology Kidney - drug effects Kidney - metabolism Kidney - pathology Male Neurosciences ORIGINAL PAPER Oxidative Stress - drug effects Protective Agents - therapeutic use Rats Rats, Wistar Sirtuin 1 - metabolism Tropisetron - therapeutic use
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