Emergence of Barrel Motif in Amyloid‑β Trimer: A Computational Study

Amyloid-β (Aβ) peptides form assemblies that are pathological hallmarks of Alzheimer’s disease. Aβ oligomers are soluble, mobile, and toxic forms of the peptide that act in the extracellular space before assembling into protofibrils and fibrils. Therefore, oligomers play an important role in the mec...

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Veröffentlicht in:	The journal of physical chemistry. B 2020-11, Vol.124 (47), p.10617-10631
Hauptverfasser:	Nguyen, Hoang Linh, Linh, Huynh Quang, Matteini, Paolo, La Penna, Giovanni, Li, Mai Suan
Format:	Artikel
Sprache:	eng
Schlagworte:	Alzheimer Disease Amyloid beta-Peptides B: Biophysics Physical Chemistry of Biological Systems and Biomolecules Humans Macromolecular Substances Molecular Dynamics Simulation Peptide Fragments
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