Convalescent plasma for pediatric patients with SARS‐CoV‐2‐associated acute respiratory distress syndrome
There are no proven safe and effective therapies for children who develop life‐threatening complications of severe acute respiratory syndrome coronavirus 2 (SARS‐CoV‐2). Convalescent plasma (CP) has demonstrated potential benefit in adults with SARS‐CoV‐2, but has theoretical risks.We present the fi...
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| Veröffentlicht in: | Pediatric blood & cancer 2020-11, Vol.67 (11), p.e28693-n/a |
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| creator | Diorio, Caroline Anderson, Elizabeth M. McNerney, Kevin O. Goodwin, Eileen C. Chase, Julie C. Bolton, Marcus J. Arevalo, Claudia P. Weirick, Madison E. Gouma, Sigrid Vella, Laura A. Henrickson, Sarah E. Chiotos, Kathleen Fitzgerald, Julie C. Kilbaugh, Todd J. John, Audrey R. Odom Blatz, Allison M. Lambert, Michele P. Sullivan, Kathleen E. Tartaglione, Margaret R. Zambrano, Danielle Martin, Meghan Lee, Jessica H. Young, Pampee Friedman, David Sesok‐Pizzini, Deborah A. Hensley, Scott E. Behrens, Edward M. Bassiri, Hamid Teachey, David T. |
| description | There are no proven safe and effective therapies for children who develop life‐threatening complications of severe acute respiratory syndrome coronavirus 2 (SARS‐CoV‐2). Convalescent plasma (CP) has demonstrated potential benefit in adults with SARS‐CoV‐2, but has theoretical risks.We present the first report of CP in children with life‐threatening coronavirus disease 2019 (COVID‐19), providing data on four pediatric patients with acute respiratory distress syndrome. We measured donor antibody levels and recipient antibody response prior to and following CP infusion. Infusion of CP was not associated with antibody‐dependent enhancement (ADE) and did not suppress endogenous antibody response. We found CP was safe and possibly efficacious. Randomized pediatric trials are needed. |
| doi_str_mv | 10.1002/pbc.28693 |
| format | Article |
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Odom ; Blatz, Allison M. ; Lambert, Michele P. ; Sullivan, Kathleen E. ; Tartaglione, Margaret R. ; Zambrano, Danielle ; Martin, Meghan ; Lee, Jessica H. ; Young, Pampee ; Friedman, David ; Sesok‐Pizzini, Deborah A. ; Hensley, Scott E. ; Behrens, Edward M. ; Bassiri, Hamid ; Teachey, David T.</creator><creatorcontrib>Diorio, Caroline ; Anderson, Elizabeth M. ; McNerney, Kevin O. ; Goodwin, Eileen C. ; Chase, Julie C. ; Bolton, Marcus J. ; Arevalo, Claudia P. ; Weirick, Madison E. ; Gouma, Sigrid ; Vella, Laura A. ; Henrickson, Sarah E. ; Chiotos, Kathleen ; Fitzgerald, Julie C. ; Kilbaugh, Todd J. ; John, Audrey R. Odom ; Blatz, Allison M. ; Lambert, Michele P. ; Sullivan, Kathleen E. ; Tartaglione, Margaret R. ; Zambrano, Danielle ; Martin, Meghan ; Lee, Jessica H. ; Young, Pampee ; Friedman, David ; Sesok‐Pizzini, Deborah A. ; Hensley, Scott E. ; Behrens, Edward M. ; Bassiri, Hamid ; Teachey, David T.</creatorcontrib><description>There are no proven safe and effective therapies for children who develop life‐threatening complications of severe acute respiratory syndrome coronavirus 2 (SARS‐CoV‐2). Convalescent plasma (CP) has demonstrated potential benefit in adults with SARS‐CoV‐2, but has theoretical risks.We present the first report of CP in children with life‐threatening coronavirus disease 2019 (COVID‐19), providing data on four pediatric patients with acute respiratory distress syndrome. We measured donor antibody levels and recipient antibody response prior to and following CP infusion. Infusion of CP was not associated with antibody‐dependent enhancement (ADE) and did not suppress endogenous antibody response. We found CP was safe and possibly efficacious. Randomized pediatric trials are needed.</description><identifier>ISSN: 1545-5009</identifier><identifier>EISSN: 1545-5017</identifier><identifier>DOI: 10.1002/pbc.28693</identifier><identifier>PMID: 32885904</identifier><language>eng</language><publisher>United States: Wiley Subscription Services, Inc</publisher><subject>Adolescent ; Antibodies ; Antibodies, Monoclonal, Humanized - therapeutic use ; Antibodies, Neutralizing - blood ; Antibodies, Neutralizing - therapeutic use ; Antibodies, Viral - blood ; Antibodies, Viral - therapeutic use ; Antibody response ; Children ; Clinical trials ; convalescent plasma ; Coronaviridae ; Coronaviruses ; COVID-19 ; COVID-19 - complications ; COVID-19 - therapy ; Hematology ; Humans ; Immunization, Passive - methods ; Immunoglobulin A - blood ; Immunoglobulin G - blood ; Immunoglobulin M - blood ; Oncology ; Pediatrics ; Respiratory distress syndrome ; Respiratory Distress Syndrome - etiology ; Respiratory Distress Syndrome - therapy ; SARS-CoV-2 - immunology ; SARS‐CoV‐2 ; Severe acute respiratory syndrome coronavirus 2 ; Severity of Illness Index</subject><ispartof>Pediatric blood & cancer, 2020-11, Vol.67 (11), p.e28693-n/a</ispartof><rights>2020 Wiley Periodicals LLC</rights><rights>2020 Wiley Periodicals LLC.</rights><rights>2020. 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Odom</creatorcontrib><creatorcontrib>Blatz, Allison M.</creatorcontrib><creatorcontrib>Lambert, Michele P.</creatorcontrib><creatorcontrib>Sullivan, Kathleen E.</creatorcontrib><creatorcontrib>Tartaglione, Margaret R.</creatorcontrib><creatorcontrib>Zambrano, Danielle</creatorcontrib><creatorcontrib>Martin, Meghan</creatorcontrib><creatorcontrib>Lee, Jessica H.</creatorcontrib><creatorcontrib>Young, Pampee</creatorcontrib><creatorcontrib>Friedman, David</creatorcontrib><creatorcontrib>Sesok‐Pizzini, Deborah A.</creatorcontrib><creatorcontrib>Hensley, Scott E.</creatorcontrib><creatorcontrib>Behrens, Edward M.</creatorcontrib><creatorcontrib>Bassiri, Hamid</creatorcontrib><creatorcontrib>Teachey, David T.</creatorcontrib><title>Convalescent plasma for pediatric patients with SARS‐CoV‐2‐associated acute respiratory distress syndrome</title><title>Pediatric blood & cancer</title><addtitle>Pediatr Blood Cancer</addtitle><description>There are no proven safe and effective therapies for children who develop life‐threatening complications of severe acute respiratory syndrome coronavirus 2 (SARS‐CoV‐2). Convalescent plasma (CP) has demonstrated potential benefit in adults with SARS‐CoV‐2, but has theoretical risks.We present the first report of CP in children with life‐threatening coronavirus disease 2019 (COVID‐19), providing data on four pediatric patients with acute respiratory distress syndrome. We measured donor antibody levels and recipient antibody response prior to and following CP infusion. Infusion of CP was not associated with antibody‐dependent enhancement (ADE) and did not suppress endogenous antibody response. We found CP was safe and possibly efficacious. 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| identifier | ISSN: 1545-5009 |
| ispartof | Pediatric blood & cancer, 2020-11, Vol.67 (11), p.e28693-n/a |
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| language | eng |
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| source | MEDLINE; Wiley Online Library Journals Frontfile Complete |
| subjects | Adolescent Antibodies Antibodies, Monoclonal, Humanized - therapeutic use Antibodies, Neutralizing - blood Antibodies, Neutralizing - therapeutic use Antibodies, Viral - blood Antibodies, Viral - therapeutic use Antibody response Children Clinical trials convalescent plasma Coronaviridae Coronaviruses COVID-19 COVID-19 - complications COVID-19 - therapy Hematology Humans Immunization, Passive - methods Immunoglobulin A - blood Immunoglobulin G - blood Immunoglobulin M - blood Oncology Pediatrics Respiratory distress syndrome Respiratory Distress Syndrome - etiology Respiratory Distress Syndrome - therapy SARS-CoV-2 - immunology SARS‐CoV‐2 Severe acute respiratory syndrome coronavirus 2 Severity of Illness Index |
| title | Convalescent plasma for pediatric patients with SARS‐CoV‐2‐associated acute respiratory distress syndrome |
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