CDK12 and HER2 coamplification in two urothelial carcinomas with rapid and aggressive clinical progression

Cyclin‐dependent kinase 12 (CDK12), one of the key factors associated with DNA damage response pathways, is located on chromosome 17 proximal to Erb‐B2 receptor tyrosine kinase 2 (ERBB2). In this report, CDK12 and ERBB2 coamplification was detected by targeted next‐generation sequencing in two uroth...

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Veröffentlicht in:	Cancer science 2020-12, Vol.111 (12), p.4652-4655
Hauptverfasser:	Yanai, Yoshinori, Kosaka, Takeo, Nakamura, Kohei, Aimono, Eriko, Matsumoto, Kazuhiro, Morita, Shinya, Mikami, Shuji, Nishihara, Hiroshi, Oya, Mototsugu
Format:	Artikel
Sprache:	eng
Schlagworte:	Adenocarcinoma - genetics Adenocarcinoma - therapy Aged Aged, 80 and over Apoptosis BCG BCG vaccines Biopsy Bladder cancer Breast cancer Cancer Cancer therapies Carcinoma, Transitional Cell - genetics Carcinoma, Transitional Cell - therapy Case Report CDK12 amplification Chromosome 17 Conflicts of interest Cyclin-dependent kinases Cyclin-Dependent Kinases - genetics Development and progression Disease Progression DNA damage DNA repair gene Epidermal growth factor ErbB-2 protein ERBB2 Fatal Outcome Gene Amplification Genes, erbB-2 Genes, p53 Genetic aspects Health aspects Hematuria Humans Kidney Neoplasms - genetics Kidney Neoplasms - therapy Kinases Male Medical prognosis Metastasis Mutation Patients Prostate cancer Prostatic Neoplasms - genetics Prostatic Neoplasms - therapy Protein-tyrosine kinase receptors Radiation therapy Tumors Urinary Bladder Neoplasms - genetics Urinary Bladder Neoplasms - pathology Urinary Bladder Neoplasms - therapy Urothelial carcinoma
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