Overexpression of SARS-CoV-2 protein ORF6 dislocates RAE1 and NUP98 from the nuclear pore complex

The novel human betacoronavirus SARS-CoV-2 has caused an unprecedented pandemic in the 21st century. Several studies have revealed interactions between SARS-CoV-2 viral proteins and host nucleoporins, yet their functions are largely unknown. Here, we demonstrate that the open-reading frame 6 (ORF6)...

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Veröffentlicht in:	Biochemical and biophysical research communications 2021-01, Vol.536, p.59-66
Hauptverfasser:	Kato, Koki, Ikliptikawati, Dini Kurnia, Kobayashi, Akiko, Kondo, Hiroya, Lim, Keesiang, Hazawa, Masaharu, Wong, Richard W.
Format:	Artikel
Sprache:	eng
Schlagworte:	Active Transport, Cell Nucleus Cell Nucleus - virology Cell Nucleus Size HEK293 Cells Heterogeneous Nuclear Ribonucleoprotein A1 - metabolism hnRNPA1 Humans Nuclear Matrix-Associated Proteins - metabolism Nuclear Pore Complex Proteins - metabolism Nucleocytoplasmic Transport Proteins - metabolism NUP98 RAE1 SARS-CoV-2 SARS-CoV-2 ORF6 Viral Proteins - metabolism
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