Anti-hepatitis C Virus Activity of Novel β-D-2′-C-methyl-4′-azido Pyrimidine Nucleoside Phosphoramidate Prodrugs

Background: 2′-C-methyl and 4′-azido nucleosides have previously demonstrated inhibition of hepatitis C virus (HCV) replication by targeting the RNA-dependent RNA polymerase NS5B. In an effort to discover new and more potent anti-HCV agents, we envisioned synthesizing nucleoside analogues by combini...

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Veröffentlicht in:	Antiviral chemistry & chemotherapy 2009-10, Vol.20 (2), p.99-106
Hauptverfasser:	Rondla, Ramu, Coats, Steven J, McBrayer, Tamara R, Grier, Jason, Johns, Melissa, Tharnish, Phillip M, Whitaker, Tony, Zhou, Longhu, Schinazi, Raymond F
Format:	Artikel
Sprache:	eng
Schlagworte:	Amides Antiretroviral drugs Antiviral Agents - chemical synthesis Antiviral Agents - pharmacology Cell Line Cell Survival - drug effects Cytidine - analogs & derivatives Cytotoxicity DNA-directed RNA polymerase Hepacivirus - drug effects Hepatitis Hepatitis C Humans Iodine Nucleoside analogs Phosphoric Acids Phosphorylation Prodrugs Prodrugs - pharmacology Prodrugs - therapeutic use Pyrimidine Nucleosides - pharmacology Pyrimidine Nucleosides - therapeutic use Replication RNA polymerase RNA-directed RNA polymerase rRNA Thymidine Uridine Uridine - analogs & derivatives Virus Replication - drug effects
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