High-Efficiency Production of Radiopharmaceuticals via Droplet Radiochemistry: A Review of Recent Progress
New platforms are enabling radiochemistry to be carried out in tiny, microliter-scale volumes, and this capability has enormous benefits for the production of radiopharmaceuticals. These droplet-based technologies can achieve comparable or better yields compared to conventional methods, but with vas...
Gespeichert in:
| Veröffentlicht in: | Molecular Imaging 2020, Vol.19, p.1536012120973099-1536012120973099 |
|---|---|
| Hauptverfasser: | , |
| Format: | Artikel |
| Sprache: | eng |
| Schlagworte: | |
| Online-Zugang: | Volltext |
| Tags: |
Tag hinzufügen
Keine Tags, Fügen Sie den ersten Tag hinzu!
|
| container_end_page | 1536012120973099 |
|---|---|
| container_issue | |
| container_start_page | 1536012120973099 |
| container_title | Molecular Imaging |
| container_volume | 19 |
| creator | Wang, Jia van Dam, R. Michael |
| description | New platforms are enabling radiochemistry to be carried out in tiny, microliter-scale volumes, and this capability has enormous benefits for the production of radiopharmaceuticals. These droplet-based technologies can achieve comparable or better yields compared to conventional methods, but with vastly reduced reagent consumption, shorter synthesis time, higher molar activity (even for low activity batches), faster purification, and ultra-compact system size. We review here the state of the art of this emerging direction, summarize the radiotracers and prosthetic groups that have been synthesized in droplet format, describe recent achievements in scaling up activity levels, and discuss advantages and limitations and the future outlook of these innovative devices. |
| doi_str_mv | 10.1177/1536012120973099 |
| format | Article |
| fullrecord | <record><control><sourceid>proquest_pubme</sourceid><recordid>TN_cdi_pubmedcentral_primary_oai_pubmedcentral_nih_gov_7731702</recordid><sourceformat>XML</sourceformat><sourcesystem>PC</sourcesystem><sage_id>10.1177_1536012120973099</sage_id><sourcerecordid>2473712223</sourcerecordid><originalsourceid>FETCH-LOGICAL-c462t-3e4d92c8ea1e3ed5ae946c29d308592eac2bd0e3f2a5652664a47fdbc24cf2de3</originalsourceid><addsrcrecordid>eNp1kUtr3DAUhUVpaB7tvqti6CYbJ9KVLY26CIQ0LwgkhHYtNNL1jAaPNZHsKfPvI2eSNA10JXH1naN7OIR8ZfSIMSmPWc0FZcCAKsmpUh_I3jgqx9nHp3td8ppOdsl-SgtKgYJSn8gu56AESNgjiys_m5fnTeOtx85uirsY3GB7H7oiNMW9cT6s5iYujcWh99a0qVh7U_yMYdVivwXsHJc-9XHzozgt7nHt8c-TGC12_eg4i5jSZ7LTZDl-eT4PyO-L819nV-XN7eX12elNaSsBfcmxcgrsBA1Djq42qCphQTlOJ7UCNBamjiJvwNSiBiEqU8nGTS1UtgGH_ICcbH1Xw3SJbtwhmlavol-auNHBeP3vS-fnehbWWkrOJIVscPhsEMPDgKnXOZ3FtjUdhiFpqISiUjElMvr9HboIQ-xyvExJLhkA8EzRLWVjSCli87oMo3osUr8vMku-vQ3xKnhpLgPlFkhmhn9__a_hIyfFp2Y</addsrcrecordid><sourcetype>Open Access Repository</sourcetype><iscdi>true</iscdi><recordtype>article</recordtype><pqid>2473712223</pqid></control><display><type>article</type><title>High-Efficiency Production of Radiopharmaceuticals via Droplet Radiochemistry: A Review of Recent Progress</title><source>DOAJ Directory of Open Access Journals</source><source>Elektronische Zeitschriftenbibliothek - Frei zugängliche E-Journals</source><source>PubMed Central</source><source>PubMed Central Open Access</source><creator>Wang, Jia ; van Dam, R. Michael</creator><creatorcontrib>Wang, Jia ; van Dam, R. Michael</creatorcontrib><description>New platforms are enabling radiochemistry to be carried out in tiny, microliter-scale volumes, and this capability has enormous benefits for the production of radiopharmaceuticals. These droplet-based technologies can achieve comparable or better yields compared to conventional methods, but with vastly reduced reagent consumption, shorter synthesis time, higher molar activity (even for low activity batches), faster purification, and ultra-compact system size. We review here the state of the art of this emerging direction, summarize the radiotracers and prosthetic groups that have been synthesized in droplet format, describe recent achievements in scaling up activity levels, and discuss advantages and limitations and the future outlook of these innovative devices.</description><identifier>ISSN: 1535-3508</identifier><identifier>EISSN: 1536-0121</identifier><identifier>DOI: 10.1177/1536012120973099</identifier><identifier>PMID: 33296272</identifier><language>eng</language><publisher>Los Angeles, CA: SAGE Publications</publisher><subject>Chemical reduction ; Droplets ; Prostheses ; Prosthetic groups ; Radioactive tracers ; Radiochemistry ; Reagents ; Review ; State-of-the-art reviews</subject><ispartof>Molecular Imaging, 2020, Vol.19, p.1536012120973099-1536012120973099</ispartof><rights>SAGE Publications Inc. 2020</rights><rights>SAGE Publications Inc. 2020. This work is licensed under the Creative Commons Attribution – Non-Commercial License https://creativecommons.org/licenses/by-nc/4.0/ (the “License”). Notwithstanding the ProQuest Terms and Conditions, you may use this content in accordance with the terms of the License.</rights><rights>SAGE Publications Inc. 2020 2020 SAGE Publications Inc.</rights><lds50>peer_reviewed</lds50><oa>free_for_read</oa><woscitedreferencessubscribed>false</woscitedreferencessubscribed><citedby>FETCH-LOGICAL-c462t-3e4d92c8ea1e3ed5ae946c29d308592eac2bd0e3f2a5652664a47fdbc24cf2de3</citedby><cites>FETCH-LOGICAL-c462t-3e4d92c8ea1e3ed5ae946c29d308592eac2bd0e3f2a5652664a47fdbc24cf2de3</cites><orcidid>0000-0002-0070-1320 ; 0000-0003-2316-0173</orcidid></display><links><openurl>$$Topenurl_article</openurl><openurlfulltext>$$Topenurlfull_article</openurlfulltext><thumbnail>$$Tsyndetics_thumb_exl</thumbnail><linktopdf>$$Uhttps://www.ncbi.nlm.nih.gov/pmc/articles/PMC7731702/pdf/$$EPDF$$P50$$Gpubmedcentral$$Hfree_for_read</linktopdf><linktohtml>$$Uhttps://www.ncbi.nlm.nih.gov/pmc/articles/PMC7731702/$$EHTML$$P50$$Gpubmedcentral$$Hfree_for_read</linktohtml><link.rule.ids>230,313,314,723,776,780,788,860,881,4010,4040,27899,27900,27901,27902,53766,53768</link.rule.ids><backlink>$$Uhttps://www.ncbi.nlm.nih.gov/pubmed/33296272$$D View this record in MEDLINE/PubMed$$Hfree_for_read</backlink></links><search><creatorcontrib>Wang, Jia</creatorcontrib><creatorcontrib>van Dam, R. Michael</creatorcontrib><title>High-Efficiency Production of Radiopharmaceuticals via Droplet Radiochemistry: A Review of Recent Progress</title><title>Molecular Imaging</title><addtitle>Mol Imaging</addtitle><description>New platforms are enabling radiochemistry to be carried out in tiny, microliter-scale volumes, and this capability has enormous benefits for the production of radiopharmaceuticals. These droplet-based technologies can achieve comparable or better yields compared to conventional methods, but with vastly reduced reagent consumption, shorter synthesis time, higher molar activity (even for low activity batches), faster purification, and ultra-compact system size. We review here the state of the art of this emerging direction, summarize the radiotracers and prosthetic groups that have been synthesized in droplet format, describe recent achievements in scaling up activity levels, and discuss advantages and limitations and the future outlook of these innovative devices.</description><subject>Chemical reduction</subject><subject>Droplets</subject><subject>Prostheses</subject><subject>Prosthetic groups</subject><subject>Radioactive tracers</subject><subject>Radiochemistry</subject><subject>Reagents</subject><subject>Review</subject><subject>State-of-the-art reviews</subject><issn>1535-3508</issn><issn>1536-0121</issn><fulltext>true</fulltext><rsrctype>article</rsrctype><creationdate>2020</creationdate><recordtype>article</recordtype><sourceid>AFRWT</sourceid><sourceid>BENPR</sourceid><recordid>eNp1kUtr3DAUhUVpaB7tvqti6CYbJ9KVLY26CIQ0LwgkhHYtNNL1jAaPNZHsKfPvI2eSNA10JXH1naN7OIR8ZfSIMSmPWc0FZcCAKsmpUh_I3jgqx9nHp3td8ppOdsl-SgtKgYJSn8gu56AESNgjiys_m5fnTeOtx85uirsY3GB7H7oiNMW9cT6s5iYujcWh99a0qVh7U_yMYdVivwXsHJc-9XHzozgt7nHt8c-TGC12_eg4i5jSZ7LTZDl-eT4PyO-L819nV-XN7eX12elNaSsBfcmxcgrsBA1Djq42qCphQTlOJ7UCNBamjiJvwNSiBiEqU8nGTS1UtgGH_ICcbH1Xw3SJbtwhmlavol-auNHBeP3vS-fnehbWWkrOJIVscPhsEMPDgKnXOZ3FtjUdhiFpqISiUjElMvr9HboIQ-xyvExJLhkA8EzRLWVjSCli87oMo3osUr8vMku-vQ3xKnhpLgPlFkhmhn9__a_hIyfFp2Y</recordid><startdate>2020</startdate><enddate>2020</enddate><creator>Wang, Jia</creator><creator>van Dam, R. Michael</creator><general>SAGE Publications</general><general>Sage Publications Ltd</general><scope>AFRWT</scope><scope>NPM</scope><scope>AAYXX</scope><scope>CITATION</scope><scope>7QO</scope><scope>8FD</scope><scope>ABUWG</scope><scope>AEUYN</scope><scope>AFKRA</scope><scope>AZQEC</scope><scope>BENPR</scope><scope>CCPQU</scope><scope>DWQXO</scope><scope>FR3</scope><scope>P64</scope><scope>PHGZM</scope><scope>PHGZT</scope><scope>PIMPY</scope><scope>PKEHL</scope><scope>PQEST</scope><scope>PQQKQ</scope><scope>PQUKI</scope><scope>PRINS</scope><scope>7X8</scope><scope>5PM</scope><orcidid>https://orcid.org/0000-0002-0070-1320</orcidid><orcidid>https://orcid.org/0000-0003-2316-0173</orcidid></search><sort><creationdate>2020</creationdate><title>High-Efficiency Production of Radiopharmaceuticals via Droplet Radiochemistry: A Review of Recent Progress</title><author>Wang, Jia ; van Dam, R. Michael</author></sort><facets><frbrtype>5</frbrtype><frbrgroupid>cdi_FETCH-LOGICAL-c462t-3e4d92c8ea1e3ed5ae946c29d308592eac2bd0e3f2a5652664a47fdbc24cf2de3</frbrgroupid><rsrctype>articles</rsrctype><prefilter>articles</prefilter><language>eng</language><creationdate>2020</creationdate><topic>Chemical reduction</topic><topic>Droplets</topic><topic>Prostheses</topic><topic>Prosthetic groups</topic><topic>Radioactive tracers</topic><topic>Radiochemistry</topic><topic>Reagents</topic><topic>Review</topic><topic>State-of-the-art reviews</topic><toplevel>peer_reviewed</toplevel><toplevel>online_resources</toplevel><creatorcontrib>Wang, Jia</creatorcontrib><creatorcontrib>van Dam, R. Michael</creatorcontrib><collection>Sage Journals GOLD Open Access 2024</collection><collection>PubMed</collection><collection>CrossRef</collection><collection>Biotechnology Research Abstracts</collection><collection>Technology Research Database</collection><collection>ProQuest Central (Alumni Edition)</collection><collection>ProQuest One Sustainability</collection><collection>ProQuest Central UK/Ireland</collection><collection>ProQuest Central Essentials</collection><collection>ProQuest Central</collection><collection>ProQuest One Community College</collection><collection>ProQuest Central Korea</collection><collection>Engineering Research Database</collection><collection>Biotechnology and BioEngineering Abstracts</collection><collection>ProQuest Central (New)</collection><collection>ProQuest One Academic (New)</collection><collection>Publicly Available Content Database</collection><collection>ProQuest One Academic Middle East (New)</collection><collection>ProQuest One Academic Eastern Edition (DO NOT USE)</collection><collection>ProQuest One Academic</collection><collection>ProQuest One Academic UKI Edition</collection><collection>ProQuest Central China</collection><collection>MEDLINE - Academic</collection><collection>PubMed Central (Full Participant titles)</collection><jtitle>Molecular Imaging</jtitle></facets><delivery><delcategory>Remote Search Resource</delcategory><fulltext>fulltext</fulltext></delivery><addata><au>Wang, Jia</au><au>van Dam, R. Michael</au><format>journal</format><genre>article</genre><ristype>JOUR</ristype><atitle>High-Efficiency Production of Radiopharmaceuticals via Droplet Radiochemistry: A Review of Recent Progress</atitle><jtitle>Molecular Imaging</jtitle><addtitle>Mol Imaging</addtitle><date>2020</date><risdate>2020</risdate><volume>19</volume><spage>1536012120973099</spage><epage>1536012120973099</epage><pages>1536012120973099-1536012120973099</pages><issn>1535-3508</issn><eissn>1536-0121</eissn><abstract>New platforms are enabling radiochemistry to be carried out in tiny, microliter-scale volumes, and this capability has enormous benefits for the production of radiopharmaceuticals. These droplet-based technologies can achieve comparable or better yields compared to conventional methods, but with vastly reduced reagent consumption, shorter synthesis time, higher molar activity (even for low activity batches), faster purification, and ultra-compact system size. We review here the state of the art of this emerging direction, summarize the radiotracers and prosthetic groups that have been synthesized in droplet format, describe recent achievements in scaling up activity levels, and discuss advantages and limitations and the future outlook of these innovative devices.</abstract><cop>Los Angeles, CA</cop><pub>SAGE Publications</pub><pmid>33296272</pmid><doi>10.1177/1536012120973099</doi><orcidid>https://orcid.org/0000-0002-0070-1320</orcidid><orcidid>https://orcid.org/0000-0003-2316-0173</orcidid><oa>free_for_read</oa></addata></record> |
| fulltext | fulltext |
| identifier | ISSN: 1535-3508 |
| ispartof | Molecular Imaging, 2020, Vol.19, p.1536012120973099-1536012120973099 |
| issn | 1535-3508 1536-0121 |
| language | eng |
| recordid | cdi_pubmedcentral_primary_oai_pubmedcentral_nih_gov_7731702 |
| source | DOAJ Directory of Open Access Journals; Elektronische Zeitschriftenbibliothek - Frei zugängliche E-Journals; PubMed Central; PubMed Central Open Access |
| subjects | Chemical reduction Droplets Prostheses Prosthetic groups Radioactive tracers Radiochemistry Reagents Review State-of-the-art reviews |
| title | High-Efficiency Production of Radiopharmaceuticals via Droplet Radiochemistry: A Review of Recent Progress |
| url | https://sfx.bib-bvb.de/sfx_tum?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&ctx_tim=2025-02-21T18%3A13%3A39IST&url_ver=Z39.88-2004&url_ctx_fmt=infofi/fmt:kev:mtx:ctx&rfr_id=info:sid/primo.exlibrisgroup.com:primo3-Article-proquest_pubme&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.atitle=High-Efficiency%20Production%20of%20Radiopharmaceuticals%20via%20Droplet%20Radiochemistry:%20A%20Review%20of%20Recent%20Progress&rft.jtitle=Molecular%20Imaging&rft.au=Wang,%20Jia&rft.date=2020&rft.volume=19&rft.spage=1536012120973099&rft.epage=1536012120973099&rft.pages=1536012120973099-1536012120973099&rft.issn=1535-3508&rft.eissn=1536-0121&rft_id=info:doi/10.1177/1536012120973099&rft_dat=%3Cproquest_pubme%3E2473712223%3C/proquest_pubme%3E%3Curl%3E%3C/url%3E&disable_directlink=true&sfx.directlink=off&sfx.report_link=0&rft_id=info:oai/&rft_pqid=2473712223&rft_id=info:pmid/33296272&rft_sage_id=10.1177_1536012120973099&rfr_iscdi=true |