Cyclodextrin-Based Nanostructure Efficiently Delivers siRNA to Glioblastoma Cells Preferentially via Macropinocytosis

Small interfering ribonucleic acid (siRNA) has the potential to revolutionize therapeutics since it can knockdown very efficiently the target protein. It is starting to be widely used to interfere with cell infection by HIV. However, naked siRNAs are unable to get into the cell, requiring the use of...

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Veröffentlicht in:	International journal of molecular sciences 2020-12, Vol.21 (23), p.9306
Hauptverfasser:	Manzanares, Darío, Pérez-Carrión, María Dolores, Jiménez Blanco, José Luis, Ortiz Mellet, Carmen, García Fernández, José Manuel, Ceña, Valentín
Format:	Artikel
Sprache:	eng
Schlagworte:	Animals beta-Cyclodextrins - chemistry Brain cancer Brain Neoplasms - metabolism Caveolin Caveolin-1 Cell Line, Tumor Cell membranes Clathrin Cyclodextrins Efficiency Endocytosis Glioblastoma Glioblastoma - metabolism Glioblastoma cells Humans Kinases Nanoparticles Nanoparticles - chemistry Nanoparticles - metabolism p21-activated kinase Pinocytosis Proteins Rats RNA, Small Interfering - genetics siRNA Transfection Transfection - methods β-Cyclodextrin
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