Gold Nanopeanuts as Prospective Support for Cisplatin in Glioblastoma Nano-Chemo-Radiotherapy
Herein, we propose newly designed and synthesized gold nanopeanuts (Au NPes) as supports for cisplatin (cPt) immobilization, dedicated to combined glioblastoma nano-chemo-radiotherapy. Au NPes offer a large active surface, which can be used for drugs immobilization. Transmission electron microscopy...
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| Veröffentlicht in: | International journal of molecular sciences 2020-11, Vol.21 (23), p.9082 |
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| creator | Depciuch, Joanna Miszczyk, Justyna Maximenko, Alexey Zielinski, Piotr M Rawojć, Kamila Panek, Agnieszka Olko, Pawel Parlinska-Wojtan, Magdalena |
| description | Herein, we propose newly designed and synthesized gold nanopeanuts (Au NPes) as supports for cisplatin (cPt) immobilization, dedicated to combined glioblastoma nano-chemo-radiotherapy. Au NPes offer a large active surface, which can be used for drugs immobilization. Transmission electron microscopy (TEM) revealed that the size of the synthesized Au NPes along the longitudinal axis is ~60 nm, while along the transverse axis ~20 nm. Raman, thermogravimetric analysis (TGA) and differential scanning calorimetry (DCS) measurements showed, that the created nanosystem is stable up to a temperature of 110 °C. MTT assay revealed, that the highest cell mortality was observed for cell lines subjected to nano-chemo-radiotherapy (20-55%). Hence, Au NPes with immobilized cPt (cPt@AuNPes) are a promising nanosystem to improve the therapeutic efficiency of combined nano-chemo-radiotherapy. |
| doi_str_mv | 10.3390/ijms21239082 |
| format | Article |
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Au NPes offer a large active surface, which can be used for drugs immobilization. Transmission electron microscopy (TEM) revealed that the size of the synthesized Au NPes along the longitudinal axis is ~60 nm, while along the transverse axis ~20 nm. Raman, thermogravimetric analysis (TGA) and differential scanning calorimetry (DCS) measurements showed, that the created nanosystem is stable up to a temperature of 110 °C. MTT assay revealed, that the highest cell mortality was observed for cell lines subjected to nano-chemo-radiotherapy (20-55%). Hence, Au NPes with immobilized cPt (cPt@AuNPes) are a promising nanosystem to improve the therapeutic efficiency of combined nano-chemo-radiotherapy.</description><identifier>ISSN: 1422-0067</identifier><identifier>ISSN: 1661-6596</identifier><identifier>EISSN: 1422-0067</identifier><identifier>DOI: 10.3390/ijms21239082</identifier><identifier>PMID: 33260340</identifier><language>eng</language><publisher>Switzerland: MDPI AG</publisher><subject>Brain cancer ; Brain Neoplasms - drug therapy ; Brain Neoplasms - radiotherapy ; Cancer therapies ; Cell division ; Cell Line, Tumor ; Cell lines ; Cell Survival - drug effects ; Chemotherapy ; Cisplatin ; Cisplatin - pharmacology ; Cisplatin - therapeutic use ; Cytotoxicity ; Differential scanning calorimetry ; Glioblastoma ; Glioblastoma - drug therapy ; Glioblastoma - pathology ; Glioblastoma - radiotherapy ; Gold ; Gold - chemistry ; Humans ; Immobilization ; Metal Nanoparticles - chemistry ; Metal Nanoparticles - ultrastructure ; Mortality ; Nanoparticles ; Radiation therapy ; Spectrum Analysis, Raman ; Success ; Thermogravimetric analysis ; Transmission electron microscopy ; Tumors</subject><ispartof>International journal of molecular sciences, 2020-11, Vol.21 (23), p.9082</ispartof><rights>2020. This work is licensed under http://creativecommons.org/licenses/by/3.0/ (the “License”). Notwithstanding the ProQuest Terms and Conditions, you may use this content in accordance with the terms of the License.</rights><rights>2020 by the authors. 2020</rights><lds50>peer_reviewed</lds50><oa>free_for_read</oa><woscitedreferencessubscribed>false</woscitedreferencessubscribed><citedby>FETCH-LOGICAL-c412t-9330ba9031dd7e353f657781cb58aa79c2ad8b3e686a7bf27909a31171a57bff3</citedby><cites>FETCH-LOGICAL-c412t-9330ba9031dd7e353f657781cb58aa79c2ad8b3e686a7bf27909a31171a57bff3</cites><orcidid>0000-0002-3162-2668 ; 0000-0001-5901-400X ; 0000-0003-2660-8105 ; 0000-0003-0168-1701 ; 0000-0001-5554-8178 ; 0000-0001-7226-1750</orcidid></display><links><openurl>$$Topenurl_article</openurl><openurlfulltext>$$Topenurlfull_article</openurlfulltext><thumbnail>$$Tsyndetics_thumb_exl</thumbnail><linktopdf>$$Uhttps://www.ncbi.nlm.nih.gov/pmc/articles/PMC7730046/pdf/$$EPDF$$P50$$Gpubmedcentral$$Hfree_for_read</linktopdf><linktohtml>$$Uhttps://www.ncbi.nlm.nih.gov/pmc/articles/PMC7730046/$$EHTML$$P50$$Gpubmedcentral$$Hfree_for_read</linktohtml><link.rule.ids>230,314,723,776,780,881,27901,27902,53766,53768</link.rule.ids><backlink>$$Uhttps://www.ncbi.nlm.nih.gov/pubmed/33260340$$D View this record in MEDLINE/PubMed$$Hfree_for_read</backlink></links><search><creatorcontrib>Depciuch, Joanna</creatorcontrib><creatorcontrib>Miszczyk, Justyna</creatorcontrib><creatorcontrib>Maximenko, Alexey</creatorcontrib><creatorcontrib>Zielinski, Piotr M</creatorcontrib><creatorcontrib>Rawojć, Kamila</creatorcontrib><creatorcontrib>Panek, Agnieszka</creatorcontrib><creatorcontrib>Olko, Pawel</creatorcontrib><creatorcontrib>Parlinska-Wojtan, Magdalena</creatorcontrib><title>Gold Nanopeanuts as Prospective Support for Cisplatin in Glioblastoma Nano-Chemo-Radiotherapy</title><title>International journal of molecular sciences</title><addtitle>Int J Mol Sci</addtitle><description>Herein, we propose newly designed and synthesized gold nanopeanuts (Au NPes) as supports for cisplatin (cPt) immobilization, dedicated to combined glioblastoma nano-chemo-radiotherapy. Au NPes offer a large active surface, which can be used for drugs immobilization. Transmission electron microscopy (TEM) revealed that the size of the synthesized Au NPes along the longitudinal axis is ~60 nm, while along the transverse axis ~20 nm. Raman, thermogravimetric analysis (TGA) and differential scanning calorimetry (DCS) measurements showed, that the created nanosystem is stable up to a temperature of 110 °C. MTT assay revealed, that the highest cell mortality was observed for cell lines subjected to nano-chemo-radiotherapy (20-55%). Hence, Au NPes with immobilized cPt (cPt@AuNPes) are a promising nanosystem to improve the therapeutic efficiency of combined nano-chemo-radiotherapy.</description><subject>Brain cancer</subject><subject>Brain Neoplasms - drug therapy</subject><subject>Brain Neoplasms - radiotherapy</subject><subject>Cancer therapies</subject><subject>Cell division</subject><subject>Cell Line, Tumor</subject><subject>Cell lines</subject><subject>Cell Survival - drug effects</subject><subject>Chemotherapy</subject><subject>Cisplatin</subject><subject>Cisplatin - pharmacology</subject><subject>Cisplatin - therapeutic use</subject><subject>Cytotoxicity</subject><subject>Differential scanning calorimetry</subject><subject>Glioblastoma</subject><subject>Glioblastoma - drug therapy</subject><subject>Glioblastoma - pathology</subject><subject>Glioblastoma - radiotherapy</subject><subject>Gold</subject><subject>Gold - chemistry</subject><subject>Humans</subject><subject>Immobilization</subject><subject>Metal Nanoparticles - chemistry</subject><subject>Metal Nanoparticles - ultrastructure</subject><subject>Mortality</subject><subject>Nanoparticles</subject><subject>Radiation therapy</subject><subject>Spectrum Analysis, Raman</subject><subject>Success</subject><subject>Thermogravimetric analysis</subject><subject>Transmission electron microscopy</subject><subject>Tumors</subject><issn>1422-0067</issn><issn>1661-6596</issn><issn>1422-0067</issn><fulltext>true</fulltext><rsrctype>article</rsrctype><creationdate>2020</creationdate><recordtype>article</recordtype><sourceid>EIF</sourceid><sourceid>8G5</sourceid><sourceid>BENPR</sourceid><sourceid>GUQSH</sourceid><sourceid>M2O</sourceid><recordid>eNpVUU1LxDAQDaL4ffMsBa9Wk0zbtBdBFl0FUfHjKGHapm6WtqlJuuC_N7q6rDAwb5jHe8MbQo4YPQMo6Lmed44zHmDON8guSziPKc3E5hreIXvOzSnlwNNim-wA8IxCQnfJ29S0dXSPvRkU9qN3Ebro0Ro3qMrrhYqex2Ew1keNsdFEu6FFr_so1LTVpmzRedPhj0A8manOxE9Ya-NnyuLweUC2GmydOvzt--T1-uplchPfPUxvJ5d3cZUw7uMCgJZYUGB1LRSk0GSpEDmryjRHFEXFsc5LUFmeoSgbLgpaIDAmGKZhbmCfXCx1h7HsVF2p3lts5WB1h_ZTGtTy_6bXM_luFlIIoDTJgsDJr4A1H6NyXs7NaPtws-RJJjgEaxZYp0tWFQJyVjUrB0bl9zPk-jMC_Xj9qhX5L334As9Dhwg</recordid><startdate>20201129</startdate><enddate>20201129</enddate><creator>Depciuch, Joanna</creator><creator>Miszczyk, Justyna</creator><creator>Maximenko, Alexey</creator><creator>Zielinski, Piotr M</creator><creator>Rawojć, Kamila</creator><creator>Panek, Agnieszka</creator><creator>Olko, Pawel</creator><creator>Parlinska-Wojtan, Magdalena</creator><general>MDPI AG</general><general>MDPI</general><scope>CGR</scope><scope>CUY</scope><scope>CVF</scope><scope>ECM</scope><scope>EIF</scope><scope>NPM</scope><scope>AAYXX</scope><scope>CITATION</scope><scope>3V.</scope><scope>7X7</scope><scope>7XB</scope><scope>88E</scope><scope>8FI</scope><scope>8FJ</scope><scope>8FK</scope><scope>8G5</scope><scope>ABUWG</scope><scope>AFKRA</scope><scope>AZQEC</scope><scope>BENPR</scope><scope>CCPQU</scope><scope>DWQXO</scope><scope>FYUFA</scope><scope>GHDGH</scope><scope>GNUQQ</scope><scope>GUQSH</scope><scope>K9.</scope><scope>M0S</scope><scope>M1P</scope><scope>M2O</scope><scope>MBDVC</scope><scope>PIMPY</scope><scope>PQEST</scope><scope>PQQKQ</scope><scope>PQUKI</scope><scope>PRINS</scope><scope>Q9U</scope><scope>5PM</scope><orcidid>https://orcid.org/0000-0002-3162-2668</orcidid><orcidid>https://orcid.org/0000-0001-5901-400X</orcidid><orcidid>https://orcid.org/0000-0003-2660-8105</orcidid><orcidid>https://orcid.org/0000-0003-0168-1701</orcidid><orcidid>https://orcid.org/0000-0001-5554-8178</orcidid><orcidid>https://orcid.org/0000-0001-7226-1750</orcidid></search><sort><creationdate>20201129</creationdate><title>Gold Nanopeanuts as Prospective Support for Cisplatin in Glioblastoma Nano-Chemo-Radiotherapy</title><author>Depciuch, Joanna ; 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Au NPes offer a large active surface, which can be used for drugs immobilization. Transmission electron microscopy (TEM) revealed that the size of the synthesized Au NPes along the longitudinal axis is ~60 nm, while along the transverse axis ~20 nm. Raman, thermogravimetric analysis (TGA) and differential scanning calorimetry (DCS) measurements showed, that the created nanosystem is stable up to a temperature of 110 °C. MTT assay revealed, that the highest cell mortality was observed for cell lines subjected to nano-chemo-radiotherapy (20-55%). 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| subjects | Brain cancer Brain Neoplasms - drug therapy Brain Neoplasms - radiotherapy Cancer therapies Cell division Cell Line, Tumor Cell lines Cell Survival - drug effects Chemotherapy Cisplatin Cisplatin - pharmacology Cisplatin - therapeutic use Cytotoxicity Differential scanning calorimetry Glioblastoma Glioblastoma - drug therapy Glioblastoma - pathology Glioblastoma - radiotherapy Gold Gold - chemistry Humans Immobilization Metal Nanoparticles - chemistry Metal Nanoparticles - ultrastructure Mortality Nanoparticles Radiation therapy Spectrum Analysis, Raman Success Thermogravimetric analysis Transmission electron microscopy Tumors |
| title | Gold Nanopeanuts as Prospective Support for Cisplatin in Glioblastoma Nano-Chemo-Radiotherapy |
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