Tolerance induction in memory CD4 T cells is partial and reversible

We have examined the response of memory CD4 T cells to tolerogenic signals. Although memory CD4 T cells could respond to antigen delivered without adjuvant, they undergo cell death upon further restimulation. Our data suggest that the Tcells die as a consequence of mitotic catastrophe that occurs wh...

Ausführliche Beschreibung

Gespeichert in:

Bibliographische Detailangaben
Veröffentlicht in:	Immunology 2021-01, Vol.162 (1), p.68-83
Hauptverfasser:	Gray, Joshua I., Al‐Khabouri, Shaima, Morton, Fraser, Clambey, Eric T., Gapin, Laurent, Matsuda, Jennifer L., Kappler, John W., Marrack, Philippa, Garside, Paul, Otto, Thomas D., MacLeod, Megan K.L.
Format:	Artikel
Sprache:	eng
Schlagworte:	Antigens Autoimmunity CD4 antigen Cell cycle Cell division Costimulator Cytokines DNA repair Gene expression Immunization Immunological memory Immunological tolerance Inflammation Lymphocytes Lymphocytes T memory CD4 T cells Memory cells mitotic catastrophe Molecular modelling Organs Original proliferation tolerance Transcription
Online-Zugang:	Volltext
Tags:	Tag hinzufügen Keine Tags, Fügen Sie den ersten Tag hinzu!

Schreiben Sie den ersten Kommentar!