New 1,3,4-Oxadiazole Derivatives of Pyridothiazine-1,1-Dioxide with Anti-Inflammatory Activity

Numerous studies have confirmed the coexistence of oxidative stress and inflammatory processes. Long-term inflammation and oxidative stress may significantly affect the initiation of the neoplastic transformation process. Here, we describe the synthesis of a new series of Mannich base-type hybrid co...

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Veröffentlicht in:	International journal of molecular sciences 2020-11, Vol.21 (23), p.9122
Hauptverfasser:	Glomb, Teresa, Wiatrak, Benita, Gębczak, Katarzyna, Gębarowski, Tomasz, Bodetko, Dorota, Czyżnikowska, Żaneta, Świątek, Piotr
Format:	Artikel
Sprache:	eng
Schlagworte:	Analgesics Anti-inflammatory agents Anti-Inflammatory Agents - chemistry Anti-Inflammatory Agents - pharmacology Antioxidants Cell Survival - drug effects Chemistry Coexistence Colorimetry COX-2 inhibitors Cyclooxygenase 2 - chemistry Cyclooxygenase 2 - metabolism Cyclooxygenase 2 Inhibitors - chemistry Cyclooxygenase 2 Inhibitors - pharmacology Cyclooxygenase-1 Cyclooxygenase-2 Cytotoxicity DNA Damage - drug effects Drug Design Enzymes Free radicals Humans Hybridization Inflammation Meloxicam Molecular docking Molecular Docking Simulation Molecular Dynamics Simulation Molecular Structure Nitric Oxide - metabolism Nitrogen Nonsteroidal anti-inflammatory drugs Oxadiazoles Oxadiazoles - chemistry Oxadiazoles - pharmacology Oxidative stress Oxides - chemistry Pharmaceutical sciences Physiology Protein Binding Reactive Oxygen Species - metabolism Structure-Activity Relationship Synergistic effect Thiazines - chemistry Thiazines - pharmacology
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