Multi-Omics Integration Highlights the Role of Ubiquitination in CCl4-Induced Liver Fibrosis

Liver fibrosis is the excessive accumulation of extracellular matrix proteins that occurs in chronic liver disease. Ubiquitination is a post-translational modification that is crucial for a plethora of physiological processes. Even though the ubiquitin system has been implicated in several human dis...

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Veröffentlicht in:	International journal of molecular sciences 2020-12, Vol.21 (23), p.9043
Hauptverfasser:	Mercado-Gómez, Maria, Lopitz-Otsoa, Fernando, Azkargorta, Mikel, Serrano-Maciá, Marina, Lachiondo-Ortega, Sofia, Goikoetxea-Usandizaga, Naroa, Rodríguez-Agudo, Rubén, Fernández-Ramos, David, Bizkarguenaga, Maider, Juan, Virginia Gutiérrez-de, Lectez, Benoît, Aloria, Kerman, Arizmendi, Jesus M., Simon, Jorge, Alonso, Cristina, Lozano, Juan J., Avila, Matias A., Banales, Jesus M., Marin, Jose J. G., Beraza, Naiara, Mato, José M., Elortza, Félix, Barrio, Rosa, Sutherland, James D., Mayor, Ugo, Martínez-Chantar, María L., Delgado, Teresa C.
Format:	Artikel
Sprache:	eng
Schlagworte:	Apoptosis Bile Biological activity Carbon Carbon tetrachloride Cell death Chemokines Collagen Cytokines Deoxyribonucleic acid DNA DNA damage DNA repair Enzymes Extracellular matrix Fibrosis Gene expression Genomics Kinases Lipid metabolism Lipids Liver Liver diseases Mass spectrometry Mass spectroscopy Metabolism Metabolites Metabolomics Post-translation Principal components analysis Proliferating cell nuclear antigen Proteins Proteomes Sphingolipids Transgenic mice Ubiquitin Ubiquitination
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