A Unique SEC Method Overcomes the Multiple-Monomeric-Peak Profile of the Broadly Neutralizing HIV-1 Antibody 10E8

10E8 is a potent broadly neutralizing antibody (bNAb), which targets the membrane-proximal external region (MPER) of the HIV virus. During early analytical development of this bNAb directed towards clinical evaluation, 10E8 exhibited a multiple-monomeric-peak profile caused by secondary interactions...

Ausführliche Beschreibung

Bibliographische Detailangaben

Veröffentlicht in:	Analytical chemistry (Washington) 2018-10, Vol.90 (21), p.12390-12394
Hauptverfasser:	Li, Yile, Wang, Xiangchun E., Bender, Michael F., Yang, Rong, Cozine, Taryn J., Atallah, Kandace M., Arnold, Frank, Cooper, Jonathan W., Lei, Q. Paula
Format:	Artikel
Sprache:	eng
Online-Zugang:	Volltext
Tags:	Tag hinzufügen Keine Tags, Fügen Sie den ersten Tag hinzu!