COX-2 Is Downregulated in Human Stenotic Aortic Valves and Its Inhibition Promotes Dystrophic Calcification

Calcific aortic valve disease (CAVD) is the result of maladaptive fibrocalcific processes leading to a progressive thickening and stiffening of aortic valve (AV) leaflets. CAVD is the most common cause of aortic stenosis (AS). At present, there is no effective pharmacotherapy in reducing CAVD progre...

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Veröffentlicht in:	International journal of molecular sciences 2020-11, Vol.21 (23), p.8917
Hauptverfasser:	Vieceli Dalla Sega, Francesco, Fortini, Francesca, Cimaglia, Paolo, Marracino, Luisa, Tonet, Elisabetta, Antonucci, Antonio, Moscarelli, Marco, Campo, Gianluca, Rizzo, Paola, Ferrari, Roberto
Format:	Artikel
Sprache:	eng
Schlagworte:	Age Aged Aged, 80 and over Animal models Animals Anti-inflammatory agents Aorta Aortic stenosis Aortic valve Aortic Valve - drug effects Aortic Valve - pathology Aortic Valve Stenosis - drug therapy Aortic Valve Stenosis - genetics Aortic Valve Stenosis - pathology Apoptosis Apoptosis - drug effects Calcification Calcification (ectopic) Calcinosis - drug therapy Calcinosis - genetics Calcinosis - pathology Celecoxib Celecoxib - administration & dosage Cyclooxygenase 2 - genetics Cyclooxygenase-2 Drug therapy Female Fibroblasts Gene Expression Regulation - drug effects Heart valves Humans Inflammation Inflammation - drug therapy Inflammation - genetics Inflammation - pathology Interstitial cells Male Mice Middle Aged mRNA Nodules Phenotypes Proteins RNA, Messenger - genetics Stenosis Stiffening Thickening Transforming Growth Factor beta - genetics
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