Blocking mitochondrial pyruvate import in brown adipocytes induces energy wasting via lipid cycling

Combined fatty acid esterification and lipolysis, termed lipid cycling, is an ATP‐consuming process that contributes to energy expenditure. Therefore, interventions that stimulate energy expenditure through lipid cycling are of great interest. Here we find that pharmacological and genetic inhibition...

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Veröffentlicht in:	EMBO reports 2020-12, Vol.21 (12), p.e49634-n/a
Hauptverfasser:	Veliova, Michaela, Ferreira, Caroline M, Benador, Ilan Y, Jones, Anthony E, Mahdaviani, Kiana, Brownstein, Alexandra J, Desousa, Brandon R, Acín‐Pérez, Rebeca, Petcherski, Anton, Assali, Essam A, Stiles, Linsey, Divakaruni, Ajit S, Prentki, Marc, Corkey, Barbara E, Liesa, Marc, Oliveira, Marcus F, Shirihai, Orian S
Format:	Artikel
Sprache:	eng
Schlagworte:	Adipocytes Adipocytes, Brown - metabolism Adipose Tissue, Brown - metabolism Cycles Electron transport EMBO21 Energy Energy expenditure Energy Metabolism Esterification Fatty acids futile cycle Glutamine Imports Lipid peroxidation Lipids Lipolysis Malate malate aspartate shuttle metabolism Mitochondria Mitochondria - metabolism mitochondrial pyruvate carrier Oxidation Pharmacology Pyruvic acid Pyruvic Acid - metabolism Stimulation Thermogenesis Tricarboxylic acid cycle Triglycerides Uncoupling Protein 1 - genetics Uncoupling Protein 1 - metabolism
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