Bacterial γ-glutamyltranspeptidases, physiological function, structure, catalytic mechanism and application

γ-Glutamyltranspeptidase (GGT) has been widely used as a marker enzyme of hepatic and biliary diseases and relations between various diseases and its activity have been studied extensively. Nevertheless, several of its fundamental enzymatic characteristics had not been elucidated. We obtained homoge...

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Veröffentlicht in:	Proceedings of the Japan Academy, Series B Series B, 2020/11/11, Vol.96(9), pp.440-469
Hauptverfasser:	SUZUKI, Hideyuki, FUKUYAMA, Keiichi, KUMAGAI, Hidehiko
Format:	Artikel
Sprache:	eng
Schlagworte:	Amino acids Aminocephalosporanic acid Antibiotics Bacteria Crystal structure E coli Enzymatic synthesis Enzymes Escherichia coli Food Food industry Food processing industry Functional foods & nutraceuticals Glutaminase glutathione glutathione-cycle Liver diseases Mammalian cells Mammals Metabolism Molecular weight Physiology Post-translation production of γ-glutamyl-compounds Random mutagenesis Reaction mechanisms Review Salinity tolerance Soy sauce Structure-function relationships three-dimensional structure Umami γ-Glutamyltransferase γ-glutamyltranspeptidase
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