Functional Diversification of SRSF Protein Kinase to Control Ubiquitin-Dependent Neurodevelopmental Signaling

Conserved protein kinases with core cellular functions have been frequently redeployed during metazoan evolution to regulate specialized developmental processes. The Ser/Arg (SR)-rich splicing factor (SRSF) protein kinase (SRPK), which is implicated in splicing regulation, is one such conserved euka...

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Veröffentlicht in:	Developmental cell 2020-12, Vol.55 (5), p.629-647.e7
Hauptverfasser:	Bustos, Francisco, Segarra-Fas, Anna, Nardocci, Gino, Cassidy, Andrew, Antico, Odetta, Davidson, Lindsay, Brandenburg, Lennart, Macartney, Thomas J., Toth, Rachel, Hastie, C. James, Moran, Jennifer, Gourlay, Robert, Varghese, Joby, Soares, Renata F., Montecino, Martin, Findlay, Greg M.
Format:	Artikel
Sprache:	eng
Schlagworte:	Amino Acid Motifs Amino Acid Sequence Animals Cell Nucleus - metabolism development Gene Expression Regulation, Developmental Humans Intellectual Disability - genetics Male metazoan evolution Mice Mice, Inbred C57BL Mouse Embryonic Stem Cells - metabolism Mutation - genetics Nervous System - embryology Nervous System - metabolism neural development neurodevelopmental disorders Neurons - metabolism Phosphorylation protein kinase protein phosphorylation Protein Serine-Threonine Kinases - antagonists & inhibitors Protein Serine-Threonine Kinases - chemistry Protein Serine-Threonine Kinases - metabolism Proteolysis Signal Transduction stem cells Substrate Specificity Transcription Factors - metabolism transcriptomics Ubiquitin - metabolism ubiquitin signaling Ubiquitin-Protein Ligases - metabolism
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