Protoporphyrin IX and verteporfin potently inhibit SARS-CoV-2 infection in vitro and in a mouse model expressing human ACE2

[Display omitted] The SARS-CoV-2 infection is spreading rapidly worldwide. Efficacious antiviral therapeutics against SARS-CoV-2 is urgently needed. Here, we discovered that protoporphyrin IX (PpIX) and verteporfin, two Food and Drug Administration (FDA)-approved drugs, completely inhibited the cyto...

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Veröffentlicht in:	Science bulletin (Beijing) 2021-05, Vol.66 (9), p.925-936
Hauptverfasser:	Gu, Chenjian, Wu, Yang, Guo, Huimin, Zhu, Yuanfei, Xu, Wei, Wang, Yuyan, Zhou, Yu, Sun, Zhiping, Cai, Xia, Li, Yutang, Liu, Jing, Huang, Zhong, Yuan, Zhenghong, Zhang, Rong, Deng, Qiang, Qu, Di, Xie, Youhua
Format:	Artikel
Sprache:	eng
Schlagworte:	ACE2 Protoporphyrin IX SARS-CoV-2 Verteporfin
Online-Zugang:	Volltext
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