Development of multitarget inhibitors for the treatment of pain: Design, synthesis, biological evaluation and molecular modeling studies

[Display omitted] •Potent dual inhibitors of sEH and FAAH enzymes have been discovered.•Both enzymes play an important role in pain and inflammation processes.•Several important structure-activity relationships have been observed.•Molecular modeling studies showed that these inhibitors bind in the c...

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Veröffentlicht in:	Bioorganic chemistry 2020-10, Vol.103, p.104165-104165, Article 104165
Hauptverfasser:	Wilt, Stephanie, Kodani, Sean, Le, Thanh N.H., Nguyen, Lato, Vo, Nghi, Ly, Tanya, Rodriguez, Mark, Hudson, Paula K., Morisseau, Christophe, Hammock, Bruce D., Pecic, Stevan
Format:	Artikel
Sprache:	eng
Schlagworte:	ADMET predictions Designed multiple ligands Docking experiments Enzyme inhibition Humans Models, Molecular Molecular Docking Simulation - methods Molecular modeling Pain - drug therapy Structure-Activity Relationship Structure-Activity Relationship (SAR) study
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