Androgen receptor signalling impairs docetaxel efficacy in castration-resistant prostate cancer

Androgen receptor (AR) signalling drives neoplastic growth and therapy resistance in prostate cancer. Recent clinical data show that docetaxel combined with androgen deprivation therapy improves outcome in hormone-sensitive disease. We studied whether testosterone and AR signalling interferes with d...

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Veröffentlicht in:	British journal of cancer 2020-12, Vol.123 (12), p.1715-1719
Hauptverfasser:	Mout, Lisanne, Moll, Jan M., Chen, Mingqing, de Morrée, Eleonora S., de Ridder, Corrina M. A., Gibson, Alice, Stuurman, Debra, Aghai, Ashraf, Erkens-Schulze, Sigrun, Mathijssen, Ron H. J., Sparreboom, Alex, de Wit, Ronald, Lolkema, Martijn P., van Weerden, Wytske M.
Format:	Artikel
Sprache:	eng
Schlagworte:	631/67/1059/99 631/67/589/466 Acetylation Androgen Antagonists - pharmacokinetics Androgen Antagonists - therapeutic use Androgen Receptor Antagonists - therapeutic use Androgen receptors Androgens Animals Antineoplastic Agents - pharmacokinetics Antineoplastic Agents - therapeutic use Biomedical and Life Sciences Biomedicine Brief Communication Cancer Research Castration Cell Death Cell Line, Tumor Cell Nucleus - metabolism Cell Survival Disease Progression Docetaxel - pharmacokinetics Docetaxel - therapeutic use Drug Interactions Drug Resistance Drug Resistance, Neoplasm - physiology Epidemiology Humans In Situ Nick-End Labeling Male Mice Mice, Nude Molecular Medicine Neoplasm Proteins - metabolism Neoplasm Transplantation Oncology Prostate cancer Prostate-Specific Antigen - biosynthesis Prostatic Neoplasms, Castration-Resistant - drug therapy Prostatic Neoplasms, Castration-Resistant - metabolism Prostatic Neoplasms, Castration-Resistant - pathology Receptors, Androgen - drug effects Receptors, Androgen - metabolism Signal transduction Signal Transduction - drug effects Solute Carrier Organic Anion Transporter Family Member 1B3 - metabolism Supplements Testosterone Testosterone - administration & dosage Testosterone - antagonists & inhibitors Testosterone - metabolism Testosterone - pharmacology Tubulin Tubulin - drug effects Tubulin - metabolism Tumors
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