Chemogenetic Inactivation of Orbitofrontal Cortex Decreases Cue‐induced Reinstatement of Ethanol and Sucrose Seeking in Male and Female Wistar Rats

Background The orbitofrontal cortex (OFC) encodes internal representations of outcomes and subjective value to facilitate flexible reward seeking. OFC activation is associated with drug seeking in both human subjects and animal models. OFC plays a role in alcohol use, but studies in animal models ha...

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Veröffentlicht in:	Alcoholism, clinical and experimental research clinical and experimental research, 2020-09, Vol.44 (9), p.1769-1782
Hauptverfasser:	Hernandez, John S., Binette, Annalise N., Rahman, Taryn, Tarantino, Jeffrey D., Moorman, David E.
Format:	Artikel
Sprache:	eng
Schlagworte:	Alcohol Alcohol use Alcoholism Animal models DREADD Drinking behavior Drug abuse Drug addiction Ethanol External stimuli Operant conditioning Prefrontal Reinforcement Reinstatement Relapse Rodents Sex Differences Sucrose
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