Biglycan and chondroitin sulfate play pivotal roles in bone toughness via retaining bound water in bone mineral matrix

•Glycosaminoglycans (GAGs) and proteoglycans in bone matrix regulate tissue-level hydration status and mechanical behaviors.•Deletion of biglycan (Bgn) decreased the amount of GAGs, chondroitin sulfate (CS) and bound water in mouse bone matrix.•Bgn deficiency is associated with reduction of bone tou...

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Veröffentlicht in:	Matrix biology 2020-12, Vol.94, p.95-109
Hauptverfasser:	Hua, Rui, Ni, Qingwen, Eliason, Travis D., Han, Yan, Gu, Sumin, Nicolella, Daniel P., Wang, Xiaodu, Jiang, Jean X.
Format:	Artikel
Sprache:	eng
Schlagworte:	Animal models Biglycan Bone matrix Bone mineral density Bone toughness Bound water Chondroitin sulfate Extracellular matrix Glycosaminoglycans Leucine Mechanical properties Osteoclastogenesis Proteoglycans Rodents Supplements
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