Factors associated with social functioning among long‐term cancer survivors treated with hematopoietic stem cell transplantation as adolescents or young adults
Objective Hematopoietic stem cell transplantation (HSCT) can compromise long‐term health and social functioning. We examined the impact of physical and social‐emotional factors on the social functioning of long‐term adolescent and young adult (AYA) HSCT survivors. Methods This cross‐sectional analys...
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| Veröffentlicht in: | Psycho-oncology (Chichester, England) England), 2020-10, Vol.29 (10), p.1579-1586 |
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| creator | Walsh, Casey A. Yi, Jean C. Rosenberg, Abby R. Crouch, Marie‐Laure V. Leisenring, Wendy M. Syrjala, Karen L. |
| description | Objective
Hematopoietic stem cell transplantation (HSCT) can compromise long‐term health and social functioning. We examined the impact of physical and social‐emotional factors on the social functioning of long‐term adolescent and young adult (AYA) HSCT survivors.
Methods
This cross‐sectional analysis included HSCT recipients from the INSPIRE trial [NCT00799461] who received their first transplant between ages 15‐39. Patient‐reported outcome measures included the Short Form‐36v2, Fatigue Symptom Inventory, Cancer and Treatment Distress, and the ENRICHD Social Support Inventory. We used hierarchical multiple linear regression to identify physical and social‐emotional factors associated with social functioning at the baseline assessment, with the first block including sociodemographic and clinical factors significant at P = |
| doi_str_mv | 10.1002/pon.5460 |
| format | Article |
| fullrecord | <record><control><sourceid>proquest_pubme</sourceid><recordid>TN_cdi_pubmedcentral_primary_oai_pubmedcentral_nih_gov_7721997</recordid><sourceformat>XML</sourceformat><sourcesystem>PC</sourcesystem><sourcerecordid>2420629535</sourcerecordid><originalsourceid>FETCH-LOGICAL-c4380-4a26dc79267d4acf4ff537ea0bb77a59f20fb98f90adc53a02e7e87b7647f4383</originalsourceid><addsrcrecordid>eNp1kc9qFTEUhwdRbK2CTyABN26mZjKZyc1GkNJWoVgXug5nMie9KZnkmmRuuTsfwVfw1fokZtraquAmf8iX75zDr6peNvSwoZS93QR_2PGePqr2Gypl3fRN83g5d6KWjMu96llKl5QWWPZPq72W9WzVcrZf_TwBnUNMBFIK2kLGkVzZvCY3N0fM7HW2wVt_QWAKZXVluf7-I2OciAavMZI0x63dLpYc8UGxxgly2ASL2WqSMpYP6FyBwKeNA59hUZfSBMbgMGn0OZEQyS7MS71xdjk9r54YcAlf3O0H1deT4y9HH-qz89OPR-_Pas3bFa05sH7UQrJejBy04cZ0rUCgwyAEdNIwaga5MpLCqLsWKEOBKzGIngtTDO1B9e7Wu5mHCcellwhObaKdIO5UAKv-fvF2rS7CVgnBGilFEby5E8TwbcaU1WTTMjB4DHNSjDPaM9m1XUFf_4Nehjn6Ml6huOw7yRr2INQxpBTR3DfTULXkrkruasm9oK_-bP4e_B10Aepb4Mo63P1XpD6ff7oR_gJ7Ib3q</addsrcrecordid><sourcetype>Open Access Repository</sourcetype><iscdi>true</iscdi><recordtype>article</recordtype><pqid>2449659212</pqid></control><display><type>article</type><title>Factors associated with social functioning among long‐term cancer survivors treated with hematopoietic stem cell transplantation as adolescents or young adults</title><source>MEDLINE</source><source>Access via Wiley Online Library</source><source>Applied Social Sciences Index & Abstracts (ASSIA)</source><creator>Walsh, Casey A. ; Yi, Jean C. ; Rosenberg, Abby R. ; Crouch, Marie‐Laure V. ; Leisenring, Wendy M. ; Syrjala, Karen L.</creator><creatorcontrib>Walsh, Casey A. ; Yi, Jean C. ; Rosenberg, Abby R. ; Crouch, Marie‐Laure V. ; Leisenring, Wendy M. ; Syrjala, Karen L.</creatorcontrib><description>Objective
Hematopoietic stem cell transplantation (HSCT) can compromise long‐term health and social functioning. We examined the impact of physical and social‐emotional factors on the social functioning of long‐term adolescent and young adult (AYA) HSCT survivors.
Methods
This cross‐sectional analysis included HSCT recipients from the INSPIRE trial [NCT00799461] who received their first transplant between ages 15‐39. Patient‐reported outcome measures included the Short Form‐36v2, Fatigue Symptom Inventory, Cancer and Treatment Distress, and the ENRICHD Social Support Inventory. We used hierarchical multiple linear regression to identify physical and social‐emotional factors associated with social functioning at the baseline assessment, with the first block including sociodemographic and clinical factors significant at P = <0.10 in univariate testing, the second block including fatigue and physical function, and the third block including social support and distress.
Results
Participants (N = 279) were 52% male and 93.5% white, non‐Hispanic, with a mean age of 30.3 (SD 6.6) at first transplant. Social Functioning mean was 48.5 (SD 10.5), below age‐adjusted norms (t = −13.6, P = <0.001). In the first block, current chronic graft‐vs‐host disease accounted for 5.5% of the variance (P = <0.001). Adding fatigue and physical function explained an additional 46.6% of the variance (P = <0.001). Adding distress and social support explained an additional 7.7% of the variance (P = <0.001). The final model explained 59.8% of the variance; distress, fatigue, and physical function were significantly associated with social functioning.
Conclusions
Distress, fatigue, and physical function are associated with social functioning and interventions targeting these symptoms may help to improve SF among long‐term cancer survivors treated with HSCT as AYAs.</description><identifier>ISSN: 1057-9249</identifier><identifier>EISSN: 1099-1611</identifier><identifier>DOI: 10.1002/pon.5460</identifier><identifier>PMID: 32628342</identifier><language>eng</language><publisher>Chichester, UK: John Wiley & Sons, Ltd</publisher><subject>Adolescent ; adolescent and young adult ; AYA ; Blood cancer ; Cancer ; Cancer Survivors - psychology ; cancer survivorship ; Clinical assessment ; Cross-Sectional Studies ; distress ; Fatigue ; Fatigue - etiology ; Fatigue - psychology ; Female ; hematologic malignancy ; hematopoietic stem cell transplantation ; Hematopoietic Stem Cell Transplantation - methods ; Hematopoietic Stem Cell Transplantation - psychology ; Humans ; Male ; Neoplasms - psychology ; Neoplasms - therapy ; Physical ability ; Physical symptoms ; Psychological Distress ; psycho‐oncology ; Quality of Life - psychology ; Social Behavior ; Social functioning ; Social Interaction ; Social Support ; Sociodemographics ; Stem cell transplantation ; Stem cells ; Survivor ; Teenagers ; Transplants ; Transplants & implants ; Young Adult ; Young adults</subject><ispartof>Psycho-oncology (Chichester, England), 2020-10, Vol.29 (10), p.1579-1586</ispartof><rights>2020 John Wiley & Sons Ltd</rights><rights>2020 John Wiley & Sons Ltd.</rights><rights>2020 John Wiley & Sons, Ltd.</rights><lds50>peer_reviewed</lds50><oa>free_for_read</oa><woscitedreferencessubscribed>false</woscitedreferencessubscribed><citedby>FETCH-LOGICAL-c4380-4a26dc79267d4acf4ff537ea0bb77a59f20fb98f90adc53a02e7e87b7647f4383</citedby><cites>FETCH-LOGICAL-c4380-4a26dc79267d4acf4ff537ea0bb77a59f20fb98f90adc53a02e7e87b7647f4383</cites><orcidid>0000-0002-7608-607X ; 0000-0003-4926-5301</orcidid></display><links><openurl>$$Topenurl_article</openurl><openurlfulltext>$$Topenurlfull_article</openurlfulltext><thumbnail>$$Tsyndetics_thumb_exl</thumbnail><linktopdf>$$Uhttps://onlinelibrary.wiley.com/doi/pdf/10.1002%2Fpon.5460$$EPDF$$P50$$Gwiley$$H</linktopdf><linktohtml>$$Uhttps://onlinelibrary.wiley.com/doi/full/10.1002%2Fpon.5460$$EHTML$$P50$$Gwiley$$H</linktohtml><link.rule.ids>230,314,780,784,885,1417,27924,27925,30999,45574,45575</link.rule.ids><backlink>$$Uhttps://www.ncbi.nlm.nih.gov/pubmed/32628342$$D View this record in MEDLINE/PubMed$$Hfree_for_read</backlink></links><search><creatorcontrib>Walsh, Casey A.</creatorcontrib><creatorcontrib>Yi, Jean C.</creatorcontrib><creatorcontrib>Rosenberg, Abby R.</creatorcontrib><creatorcontrib>Crouch, Marie‐Laure V.</creatorcontrib><creatorcontrib>Leisenring, Wendy M.</creatorcontrib><creatorcontrib>Syrjala, Karen L.</creatorcontrib><title>Factors associated with social functioning among long‐term cancer survivors treated with hematopoietic stem cell transplantation as adolescents or young adults</title><title>Psycho-oncology (Chichester, England)</title><addtitle>Psychooncology</addtitle><description>Objective
Hematopoietic stem cell transplantation (HSCT) can compromise long‐term health and social functioning. We examined the impact of physical and social‐emotional factors on the social functioning of long‐term adolescent and young adult (AYA) HSCT survivors.
Methods
This cross‐sectional analysis included HSCT recipients from the INSPIRE trial [NCT00799461] who received their first transplant between ages 15‐39. Patient‐reported outcome measures included the Short Form‐36v2, Fatigue Symptom Inventory, Cancer and Treatment Distress, and the ENRICHD Social Support Inventory. We used hierarchical multiple linear regression to identify physical and social‐emotional factors associated with social functioning at the baseline assessment, with the first block including sociodemographic and clinical factors significant at P = <0.10 in univariate testing, the second block including fatigue and physical function, and the third block including social support and distress.
Results
Participants (N = 279) were 52% male and 93.5% white, non‐Hispanic, with a mean age of 30.3 (SD 6.6) at first transplant. Social Functioning mean was 48.5 (SD 10.5), below age‐adjusted norms (t = −13.6, P = <0.001). In the first block, current chronic graft‐vs‐host disease accounted for 5.5% of the variance (P = <0.001). Adding fatigue and physical function explained an additional 46.6% of the variance (P = <0.001). Adding distress and social support explained an additional 7.7% of the variance (P = <0.001). The final model explained 59.8% of the variance; distress, fatigue, and physical function were significantly associated with social functioning.
Conclusions
Distress, fatigue, and physical function are associated with social functioning and interventions targeting these symptoms may help to improve SF among long‐term cancer survivors treated with HSCT as AYAs.</description><subject>Adolescent</subject><subject>adolescent and young adult</subject><subject>AYA</subject><subject>Blood cancer</subject><subject>Cancer</subject><subject>Cancer Survivors - psychology</subject><subject>cancer survivorship</subject><subject>Clinical assessment</subject><subject>Cross-Sectional Studies</subject><subject>distress</subject><subject>Fatigue</subject><subject>Fatigue - etiology</subject><subject>Fatigue - psychology</subject><subject>Female</subject><subject>hematologic malignancy</subject><subject>hematopoietic stem cell transplantation</subject><subject>Hematopoietic Stem Cell Transplantation - methods</subject><subject>Hematopoietic Stem Cell Transplantation - psychology</subject><subject>Humans</subject><subject>Male</subject><subject>Neoplasms - psychology</subject><subject>Neoplasms - therapy</subject><subject>Physical ability</subject><subject>Physical symptoms</subject><subject>Psychological Distress</subject><subject>psycho‐oncology</subject><subject>Quality of Life - psychology</subject><subject>Social Behavior</subject><subject>Social functioning</subject><subject>Social Interaction</subject><subject>Social Support</subject><subject>Sociodemographics</subject><subject>Stem cell transplantation</subject><subject>Stem cells</subject><subject>Survivor</subject><subject>Teenagers</subject><subject>Transplants</subject><subject>Transplants & implants</subject><subject>Young Adult</subject><subject>Young adults</subject><issn>1057-9249</issn><issn>1099-1611</issn><fulltext>true</fulltext><rsrctype>article</rsrctype><creationdate>2020</creationdate><recordtype>article</recordtype><sourceid>EIF</sourceid><sourceid>7QJ</sourceid><recordid>eNp1kc9qFTEUhwdRbK2CTyABN26mZjKZyc1GkNJWoVgXug5nMie9KZnkmmRuuTsfwVfw1fokZtraquAmf8iX75zDr6peNvSwoZS93QR_2PGePqr2Gypl3fRN83g5d6KWjMu96llKl5QWWPZPq72W9WzVcrZf_TwBnUNMBFIK2kLGkVzZvCY3N0fM7HW2wVt_QWAKZXVluf7-I2OciAavMZI0x63dLpYc8UGxxgly2ASL2WqSMpYP6FyBwKeNA59hUZfSBMbgMGn0OZEQyS7MS71xdjk9r54YcAlf3O0H1deT4y9HH-qz89OPR-_Pas3bFa05sH7UQrJejBy04cZ0rUCgwyAEdNIwaga5MpLCqLsWKEOBKzGIngtTDO1B9e7Wu5mHCcellwhObaKdIO5UAKv-fvF2rS7CVgnBGilFEby5E8TwbcaU1WTTMjB4DHNSjDPaM9m1XUFf_4Nehjn6Ml6huOw7yRr2INQxpBTR3DfTULXkrkruasm9oK_-bP4e_B10Aepb4Mo63P1XpD6ff7oR_gJ7Ib3q</recordid><startdate>202010</startdate><enddate>202010</enddate><creator>Walsh, Casey A.</creator><creator>Yi, Jean C.</creator><creator>Rosenberg, Abby R.</creator><creator>Crouch, Marie‐Laure V.</creator><creator>Leisenring, Wendy M.</creator><creator>Syrjala, Karen L.</creator><general>John Wiley & Sons, Ltd</general><general>Wiley Subscription Services, Inc</general><scope>CGR</scope><scope>CUY</scope><scope>CVF</scope><scope>ECM</scope><scope>EIF</scope><scope>NPM</scope><scope>AAYXX</scope><scope>CITATION</scope><scope>7QJ</scope><scope>ASE</scope><scope>FPQ</scope><scope>K6X</scope><scope>K9.</scope><scope>NAPCQ</scope><scope>7X8</scope><scope>5PM</scope><orcidid>https://orcid.org/0000-0002-7608-607X</orcidid><orcidid>https://orcid.org/0000-0003-4926-5301</orcidid></search><sort><creationdate>202010</creationdate><title>Factors associated with social functioning among long‐term cancer survivors treated with hematopoietic stem cell transplantation as adolescents or young adults</title><author>Walsh, Casey A. ; Yi, Jean C. ; Rosenberg, Abby R. ; Crouch, Marie‐Laure V. ; Leisenring, Wendy M. ; Syrjala, Karen L.</author></sort><facets><frbrtype>5</frbrtype><frbrgroupid>cdi_FETCH-LOGICAL-c4380-4a26dc79267d4acf4ff537ea0bb77a59f20fb98f90adc53a02e7e87b7647f4383</frbrgroupid><rsrctype>articles</rsrctype><prefilter>articles</prefilter><language>eng</language><creationdate>2020</creationdate><topic>Adolescent</topic><topic>adolescent and young adult</topic><topic>AYA</topic><topic>Blood cancer</topic><topic>Cancer</topic><topic>Cancer Survivors - psychology</topic><topic>cancer survivorship</topic><topic>Clinical assessment</topic><topic>Cross-Sectional Studies</topic><topic>distress</topic><topic>Fatigue</topic><topic>Fatigue - etiology</topic><topic>Fatigue - psychology</topic><topic>Female</topic><topic>hematologic malignancy</topic><topic>hematopoietic stem cell transplantation</topic><topic>Hematopoietic Stem Cell Transplantation - methods</topic><topic>Hematopoietic Stem Cell Transplantation - psychology</topic><topic>Humans</topic><topic>Male</topic><topic>Neoplasms - psychology</topic><topic>Neoplasms - therapy</topic><topic>Physical ability</topic><topic>Physical symptoms</topic><topic>Psychological Distress</topic><topic>psycho‐oncology</topic><topic>Quality of Life - psychology</topic><topic>Social Behavior</topic><topic>Social functioning</topic><topic>Social Interaction</topic><topic>Social Support</topic><topic>Sociodemographics</topic><topic>Stem cell transplantation</topic><topic>Stem cells</topic><topic>Survivor</topic><topic>Teenagers</topic><topic>Transplants</topic><topic>Transplants & implants</topic><topic>Young Adult</topic><topic>Young adults</topic><toplevel>peer_reviewed</toplevel><toplevel>online_resources</toplevel><creatorcontrib>Walsh, Casey A.</creatorcontrib><creatorcontrib>Yi, Jean C.</creatorcontrib><creatorcontrib>Rosenberg, Abby R.</creatorcontrib><creatorcontrib>Crouch, Marie‐Laure V.</creatorcontrib><creatorcontrib>Leisenring, Wendy M.</creatorcontrib><creatorcontrib>Syrjala, Karen L.</creatorcontrib><collection>Medline</collection><collection>MEDLINE</collection><collection>MEDLINE (Ovid)</collection><collection>MEDLINE</collection><collection>MEDLINE</collection><collection>PubMed</collection><collection>CrossRef</collection><collection>Applied Social Sciences Index & Abstracts (ASSIA)</collection><collection>British Nursing Index</collection><collection>British Nursing Index (BNI) (1985 to Present)</collection><collection>British Nursing Index</collection><collection>ProQuest Health & Medical Complete (Alumni)</collection><collection>Nursing & Allied Health Premium</collection><collection>MEDLINE - Academic</collection><collection>PubMed Central (Full Participant titles)</collection><jtitle>Psycho-oncology (Chichester, England)</jtitle></facets><delivery><delcategory>Remote Search Resource</delcategory><fulltext>fulltext</fulltext></delivery><addata><au>Walsh, Casey A.</au><au>Yi, Jean C.</au><au>Rosenberg, Abby R.</au><au>Crouch, Marie‐Laure V.</au><au>Leisenring, Wendy M.</au><au>Syrjala, Karen L.</au><format>journal</format><genre>article</genre><ristype>JOUR</ristype><atitle>Factors associated with social functioning among long‐term cancer survivors treated with hematopoietic stem cell transplantation as adolescents or young adults</atitle><jtitle>Psycho-oncology (Chichester, England)</jtitle><addtitle>Psychooncology</addtitle><date>2020-10</date><risdate>2020</risdate><volume>29</volume><issue>10</issue><spage>1579</spage><epage>1586</epage><pages>1579-1586</pages><issn>1057-9249</issn><eissn>1099-1611</eissn><abstract>Objective
Hematopoietic stem cell transplantation (HSCT) can compromise long‐term health and social functioning. We examined the impact of physical and social‐emotional factors on the social functioning of long‐term adolescent and young adult (AYA) HSCT survivors.
Methods
This cross‐sectional analysis included HSCT recipients from the INSPIRE trial [NCT00799461] who received their first transplant between ages 15‐39. Patient‐reported outcome measures included the Short Form‐36v2, Fatigue Symptom Inventory, Cancer and Treatment Distress, and the ENRICHD Social Support Inventory. We used hierarchical multiple linear regression to identify physical and social‐emotional factors associated with social functioning at the baseline assessment, with the first block including sociodemographic and clinical factors significant at P = <0.10 in univariate testing, the second block including fatigue and physical function, and the third block including social support and distress.
Results
Participants (N = 279) were 52% male and 93.5% white, non‐Hispanic, with a mean age of 30.3 (SD 6.6) at first transplant. Social Functioning mean was 48.5 (SD 10.5), below age‐adjusted norms (t = −13.6, P = <0.001). In the first block, current chronic graft‐vs‐host disease accounted for 5.5% of the variance (P = <0.001). Adding fatigue and physical function explained an additional 46.6% of the variance (P = <0.001). Adding distress and social support explained an additional 7.7% of the variance (P = <0.001). The final model explained 59.8% of the variance; distress, fatigue, and physical function were significantly associated with social functioning.
Conclusions
Distress, fatigue, and physical function are associated with social functioning and interventions targeting these symptoms may help to improve SF among long‐term cancer survivors treated with HSCT as AYAs.</abstract><cop>Chichester, UK</cop><pub>John Wiley & Sons, Ltd</pub><pmid>32628342</pmid><doi>10.1002/pon.5460</doi><tpages>8</tpages><orcidid>https://orcid.org/0000-0002-7608-607X</orcidid><orcidid>https://orcid.org/0000-0003-4926-5301</orcidid><oa>free_for_read</oa></addata></record> |
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| subjects | Adolescent adolescent and young adult AYA Blood cancer Cancer Cancer Survivors - psychology cancer survivorship Clinical assessment Cross-Sectional Studies distress Fatigue Fatigue - etiology Fatigue - psychology Female hematologic malignancy hematopoietic stem cell transplantation Hematopoietic Stem Cell Transplantation - methods Hematopoietic Stem Cell Transplantation - psychology Humans Male Neoplasms - psychology Neoplasms - therapy Physical ability Physical symptoms Psychological Distress psycho‐oncology Quality of Life - psychology Social Behavior Social functioning Social Interaction Social Support Sociodemographics Stem cell transplantation Stem cells Survivor Teenagers Transplants Transplants & implants Young Adult Young adults |
| title | Factors associated with social functioning among long‐term cancer survivors treated with hematopoietic stem cell transplantation as adolescents or young adults |
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