Nonlinear interaction between APOE ε4 allele load and age in the hippocampal surface of cognitively intact individuals

The ε4 allele of the gene Apolipoprotein E is the major genetic risk factor for Alzheimer's Disease. APOE ε4 has been associated with changes in brain structure in cognitively impaired and unimpaired subjects, including atrophy of the hippocampus, which is one of the brain structures that is ea...

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Veröffentlicht in:	Human brain mapping 2021-01, Vol.42 (1), p.47-64
Hauptverfasser:	Martí‐Juan, Gerard, Sanroma‐Guell, Gerard, Cacciaglia, Raffaele, Falcon, Carles, Operto, Grégory, Molinuevo, José Luis, González Ballester, Miguel Ángel, Gispert, Juan Domingo, Piella, Gemma
Format:	Artikel
Sprache:	eng
Schlagworte:	Age Age Factors Aged Aged, 80 and over Alleles Alzheimer Disease - diagnostic imaging Alzheimer Disease - genetics Alzheimer Disease - pathology Alzheimer's disease APOE Apolipoprotein E Apolipoprotein E4 - genetics Atlases as Topic Atrophy Brain cognitively intact Cohort Studies Diagnosis Female Genetic Predisposition to Disease Health risks Heterozygote Hippocampus Hippocampus - anatomy & histology Hippocampus - diagnostic imaging Humans Impact analysis Magnetic Resonance Imaging Male Middle Aged Multivariate analysis Neurodegenerative diseases Neuroimaging - methods Risk analysis Risk factors Surface analysis (chemical)
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