Dynamic Cardiolipin Synthesis Is Required for CD8 + T Cell Immunity

Mitochondria constantly adapt to the metabolic needs of a cell. This mitochondrial plasticity is critical to T cells, which modulate metabolism depending on antigen-driven signals and environment. We show here that de novo synthesis of the mitochondrial membrane-specific lipid cardiolipin maintains...

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Veröffentlicht in:	Cell metabolism 2020-12, Vol.32 (6), p.981-995.e7
Hauptverfasser:	Corrado, Mauro, Edwards-Hicks, Joy, Villa, Matteo, Flachsmann, Lea J, Sanin, David E, Jacobs, Maaike, Baixauli, Francesc, Stanczak, Michal, Anderson, Eve, Azuma, Mai, Quintana, Andrea, Curtis, Jonathan D, Clapes, Thomas, Grzes, Katarzyna M, Kabat, Agnieszka M, Kyle, Ryan, Patterson, Annette E, Geltink, Ramon Klein, Amulic, Borko, Steward, Colin G, Strathdee, Douglas, Trompouki, Eirini, O'Sullivan, David, Pearce, Edward J, Pearce, Erika L
Format:	Artikel
Sprache:	eng
Schlagworte:	Acyltransferases - immunology Animals Barth Syndrome - immunology Barth Syndrome - pathology Cardiolipins - immunology CD8-Positive T-Lymphocytes - cytology CD8-Positive T-Lymphocytes - immunology Cells, Cultured Female Humans Male Mice Mice, Inbred C57BL Mice, Knockout Mitochondria - immunology PTEN Phosphohydrolase - immunology
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