Probiotics for Preventing Upper Respiratory Tract Infections in Adults: A Systematic Review and Meta-Analysis of Randomized Controlled Trials
Background. Upper respiratory tract infections (URTIs) are common and burdensome infectious illness. Several trials have reported that probiotics can prevent URTIs in adults. Objectives. To evaluate the efficacy and safety of probiotics in the prevention of URTIs in adults. Methods. PubMed, Web of S...
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| Veröffentlicht in: | Evidence-based complementary and alternative medicine 2020, Vol.2020 (2020), p.1-8 |
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| creator | Li, Chaoqian Lai, Lejin Xiao, Huan Sun, Qixiang Hong, KangKang Li, Laodong Ming, Moyu |
| description | Background. Upper respiratory tract infections (URTIs) are common and burdensome infectious illness. Several trials have reported that probiotics can prevent URTIs in adults. Objectives. To evaluate the efficacy and safety of probiotics in the prevention of URTIs in adults. Methods. PubMed, Web of Science, Embase, and Cochrane Library were searched for reports published from database inception to May 14, 2020. Randomized controlled trials (RCTs) comparing probiotics with placebo for the prevention of URTIs in adults were included. Results. Six RCTs with 1551 participants were included. Compared with the placebo group, the probiotics intervention group significantly reduced the incidence of URTI episodes (RR: 0.77; 95% CI: 0.68 to 0.87; P |
| doi_str_mv | 10.1155/2020/8734140 |
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| fullrecord | <record><control><sourceid>proquest_pubme</sourceid><recordid>TN_cdi_pubmedcentral_primary_oai_pubmedcentral_nih_gov_7718055</recordid><sourceformat>XML</sourceformat><sourcesystem>PC</sourcesystem><sourcerecordid>2468659226</sourcerecordid><originalsourceid>FETCH-LOGICAL-c471t-d78878ae9d72185a0df3f0283ad85ee3ea845b14362c9f6170cc5352457f3d713</originalsourceid><addsrcrecordid>eNqNkU1vEzEQhlcIREvhxhlZ4oIES_2xXnt7QIoiPioVUZVU4mY59mzratdebCdV-A_8Z1wSwseJ04zGz7zjmbeqnhL8mhDOjymm-FgK1pAG36sOiWhI3VAp7-9z8eWgepTSDca0E0I8rA4Yox3rOn5YfT-PYelCdiahPkR0HmENPjt_hS6nCSK6gDS5qHOIG7SI2mR06nsw2QWfkPNoZldDTidohj5vUoZRF6nStHZwi7S36CNkXc-8HjbJJRR6dFGqYXTfwKJ58DmGYSjpIjo9pMfVg74EeLKLR9Xlu7eL-Yf67NP70_nsrDaNILm2QkohNXRWUCK5xrZnPaaSaSs5AAMtG74kDWup6fqWCGwMZ5w2XPTMCsKOqjdb3Wm1HMGasnHUg5qiG3XcqKCd-vvFu2t1FdZKCCIx50XgxU4ghq8rSFmNLhkYBu0hrJKiTStb3lHaFvT5P-hNWMVykJ-U4LjtOlqoV1vKxJBShH7_GYLVnc_qzme187ngz_5cYA__MrYAL7fAtfNW37r_lCv-ldn6N024KKdmPwA477vh</addsrcrecordid><sourcetype>Open Access Repository</sourcetype><iscdi>true</iscdi><recordtype>article</recordtype><pqid>2467506992</pqid></control><display><type>article</type><title>Probiotics for Preventing Upper Respiratory Tract Infections in Adults: A Systematic Review and Meta-Analysis of Randomized Controlled Trials</title><source>Wiley Online Library Open Access</source><source>EZB-FREE-00999 freely available EZB journals</source><source>PubMed Central</source><source>Alma/SFX Local Collection</source><source>PubMed Central Open Access</source><creator>Li, Chaoqian ; Lai, Lejin ; Xiao, Huan ; Sun, Qixiang ; Hong, KangKang ; Li, Laodong ; Ming, Moyu</creator><contributor>De Feo, Vincenzo</contributor><creatorcontrib>Li, Chaoqian ; Lai, Lejin ; Xiao, Huan ; Sun, Qixiang ; Hong, KangKang ; Li, Laodong ; Ming, Moyu ; De Feo, Vincenzo</creatorcontrib><description>Background. Upper respiratory tract infections (URTIs) are common and burdensome infectious illness. Several trials have reported that probiotics can prevent URTIs in adults. Objectives. To evaluate the efficacy and safety of probiotics in the prevention of URTIs in adults. Methods. PubMed, Web of Science, Embase, and Cochrane Library were searched for reports published from database inception to May 14, 2020. Randomized controlled trials (RCTs) comparing probiotics with placebo for the prevention of URTIs in adults were included. Results. Six RCTs with 1551 participants were included. Compared with the placebo group, the probiotics intervention group significantly reduced the incidence of URTI episodes (RR: 0.77; 95% CI: 0.68 to 0.87; P<0.0001; I2 = 26%), the episode rate of URTIs (rate ratio: 0.72; 95% CI: 0.60 to 0.86; P=0.0002; I2 = 99%), and the mean duration of one episode of URTI (MD: −2.66; 95% CI: −4.79 to −0.54; P=0.01; I2 = 80%). The adverse events of probiotics were mainly mild gastrointestinal symptoms. There were no significant differences in occurrence rate of adverse effects between probiotics intervention and placebo group (rate ratio: 1.01; 95% CI: 0.80 to 1.26; P=0.96; I2 = 99%). Conclusion. Low-quality evidence provides support that probiotics have potential efficacy for preventing URTI episodes in adults. More trials are required to confirm this conclusion.</description><identifier>ISSN: 1741-427X</identifier><identifier>EISSN: 1741-4288</identifier><identifier>DOI: 10.1155/2020/8734140</identifier><identifier>PMID: 33293995</identifier><language>eng</language><publisher>Cairo, Egypt: Hindawi Publishing Corporation</publisher><subject>Bias ; Clinical trials ; Infections ; Meta-analysis ; Prevention ; Probiotics ; Respiratory tract diseases ; Respiratory tract infection ; Systematic review</subject><ispartof>Evidence-based complementary and alternative medicine, 2020, Vol.2020 (2020), p.1-8</ispartof><rights>Copyright © 2020 Laodong Li et al.</rights><rights>Copyright © 2020 Laodong Li et al. This is an open access article distributed under the Creative Commons Attribution License (the “License”), which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited. Notwithstanding the ProQuest Terms and Conditions, you may use this content in accordance with the terms of the License. https://creativecommons.org/licenses/by/4.0</rights><rights>Copyright © 2020 Laodong Li et al. 2020</rights><lds50>peer_reviewed</lds50><oa>free_for_read</oa><woscitedreferencessubscribed>false</woscitedreferencessubscribed><citedby>FETCH-LOGICAL-c471t-d78878ae9d72185a0df3f0283ad85ee3ea845b14362c9f6170cc5352457f3d713</citedby><cites>FETCH-LOGICAL-c471t-d78878ae9d72185a0df3f0283ad85ee3ea845b14362c9f6170cc5352457f3d713</cites><orcidid>0000-0002-0916-3661 ; 0000-0002-6603-695X</orcidid></display><links><openurl>$$Topenurl_article</openurl><openurlfulltext>$$Topenurlfull_article</openurlfulltext><thumbnail>$$Tsyndetics_thumb_exl</thumbnail><linktopdf>$$Uhttps://www.ncbi.nlm.nih.gov/pmc/articles/PMC7718055/pdf/$$EPDF$$P50$$Gpubmedcentral$$Hfree_for_read</linktopdf><linktohtml>$$Uhttps://www.ncbi.nlm.nih.gov/pmc/articles/PMC7718055/$$EHTML$$P50$$Gpubmedcentral$$Hfree_for_read</linktohtml><link.rule.ids>230,314,723,776,780,881,4010,27900,27901,27902,53766,53768</link.rule.ids><backlink>$$Uhttps://www.ncbi.nlm.nih.gov/pubmed/33293995$$D View this record in MEDLINE/PubMed$$Hfree_for_read</backlink></links><search><contributor>De Feo, Vincenzo</contributor><creatorcontrib>Li, Chaoqian</creatorcontrib><creatorcontrib>Lai, Lejin</creatorcontrib><creatorcontrib>Xiao, Huan</creatorcontrib><creatorcontrib>Sun, Qixiang</creatorcontrib><creatorcontrib>Hong, KangKang</creatorcontrib><creatorcontrib>Li, Laodong</creatorcontrib><creatorcontrib>Ming, Moyu</creatorcontrib><title>Probiotics for Preventing Upper Respiratory Tract Infections in Adults: A Systematic Review and Meta-Analysis of Randomized Controlled Trials</title><title>Evidence-based complementary and alternative medicine</title><addtitle>Evid Based Complement Alternat Med</addtitle><description>Background. Upper respiratory tract infections (URTIs) are common and burdensome infectious illness. Several trials have reported that probiotics can prevent URTIs in adults. Objectives. To evaluate the efficacy and safety of probiotics in the prevention of URTIs in adults. Methods. PubMed, Web of Science, Embase, and Cochrane Library were searched for reports published from database inception to May 14, 2020. Randomized controlled trials (RCTs) comparing probiotics with placebo for the prevention of URTIs in adults were included. Results. Six RCTs with 1551 participants were included. Compared with the placebo group, the probiotics intervention group significantly reduced the incidence of URTI episodes (RR: 0.77; 95% CI: 0.68 to 0.87; P<0.0001; I2 = 26%), the episode rate of URTIs (rate ratio: 0.72; 95% CI: 0.60 to 0.86; P=0.0002; I2 = 99%), and the mean duration of one episode of URTI (MD: −2.66; 95% CI: −4.79 to −0.54; P=0.01; I2 = 80%). The adverse events of probiotics were mainly mild gastrointestinal symptoms. There were no significant differences in occurrence rate of adverse effects between probiotics intervention and placebo group (rate ratio: 1.01; 95% CI: 0.80 to 1.26; P=0.96; I2 = 99%). Conclusion. Low-quality evidence provides support that probiotics have potential efficacy for preventing URTI episodes in adults. More trials are required to confirm this conclusion.</description><subject>Bias</subject><subject>Clinical trials</subject><subject>Infections</subject><subject>Meta-analysis</subject><subject>Prevention</subject><subject>Probiotics</subject><subject>Respiratory tract diseases</subject><subject>Respiratory tract infection</subject><subject>Systematic review</subject><issn>1741-427X</issn><issn>1741-4288</issn><fulltext>true</fulltext><rsrctype>article</rsrctype><creationdate>2020</creationdate><recordtype>article</recordtype><sourceid>RHX</sourceid><sourceid>8G5</sourceid><sourceid>BENPR</sourceid><sourceid>GUQSH</sourceid><sourceid>M2O</sourceid><recordid>eNqNkU1vEzEQhlcIREvhxhlZ4oIES_2xXnt7QIoiPioVUZVU4mY59mzratdebCdV-A_8Z1wSwseJ04zGz7zjmbeqnhL8mhDOjymm-FgK1pAG36sOiWhI3VAp7-9z8eWgepTSDca0E0I8rA4Yox3rOn5YfT-PYelCdiahPkR0HmENPjt_hS6nCSK6gDS5qHOIG7SI2mR06nsw2QWfkPNoZldDTidohj5vUoZRF6nStHZwi7S36CNkXc-8HjbJJRR6dFGqYXTfwKJ58DmGYSjpIjo9pMfVg74EeLKLR9Xlu7eL-Yf67NP70_nsrDaNILm2QkohNXRWUCK5xrZnPaaSaSs5AAMtG74kDWup6fqWCGwMZ5w2XPTMCsKOqjdb3Wm1HMGasnHUg5qiG3XcqKCd-vvFu2t1FdZKCCIx50XgxU4ghq8rSFmNLhkYBu0hrJKiTStb3lHaFvT5P-hNWMVykJ-U4LjtOlqoV1vKxJBShH7_GYLVnc_qzme187ngz_5cYA__MrYAL7fAtfNW37r_lCv-ldn6N024KKdmPwA477vh</recordid><startdate>2020</startdate><enddate>2020</enddate><creator>Li, Chaoqian</creator><creator>Lai, Lejin</creator><creator>Xiao, Huan</creator><creator>Sun, Qixiang</creator><creator>Hong, KangKang</creator><creator>Li, Laodong</creator><creator>Ming, Moyu</creator><general>Hindawi Publishing Corporation</general><general>Hindawi</general><general>Hindawi Limited</general><scope>ADJCN</scope><scope>AHFXO</scope><scope>RHU</scope><scope>RHW</scope><scope>RHX</scope><scope>NPM</scope><scope>AAYXX</scope><scope>CITATION</scope><scope>3V.</scope><scope>7RV</scope><scope>7T5</scope><scope>7TO</scope><scope>7X7</scope><scope>7XB</scope><scope>88G</scope><scope>8AO</scope><scope>8FI</scope><scope>8FJ</scope><scope>8FK</scope><scope>8G5</scope><scope>ABUWG</scope><scope>AFKRA</scope><scope>AZQEC</scope><scope>BENPR</scope><scope>CCPQU</scope><scope>DWQXO</scope><scope>FYUFA</scope><scope>GHDGH</scope><scope>GNUQQ</scope><scope>GUQSH</scope><scope>H94</scope><scope>K9.</scope><scope>KB0</scope><scope>M0S</scope><scope>M2M</scope><scope>M2O</scope><scope>MBDVC</scope><scope>NAPCQ</scope><scope>PIMPY</scope><scope>PQEST</scope><scope>PQQKQ</scope><scope>PQUKI</scope><scope>PRINS</scope><scope>PSYQQ</scope><scope>Q9U</scope><scope>7X8</scope><scope>5PM</scope><orcidid>https://orcid.org/0000-0002-0916-3661</orcidid><orcidid>https://orcid.org/0000-0002-6603-695X</orcidid></search><sort><creationdate>2020</creationdate><title>Probiotics for Preventing Upper Respiratory Tract Infections in Adults: A Systematic Review and Meta-Analysis of Randomized Controlled Trials</title><author>Li, Chaoqian ; 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Upper respiratory tract infections (URTIs) are common and burdensome infectious illness. Several trials have reported that probiotics can prevent URTIs in adults. Objectives. To evaluate the efficacy and safety of probiotics in the prevention of URTIs in adults. Methods. PubMed, Web of Science, Embase, and Cochrane Library were searched for reports published from database inception to May 14, 2020. Randomized controlled trials (RCTs) comparing probiotics with placebo for the prevention of URTIs in adults were included. Results. Six RCTs with 1551 participants were included. Compared with the placebo group, the probiotics intervention group significantly reduced the incidence of URTI episodes (RR: 0.77; 95% CI: 0.68 to 0.87; P<0.0001; I2 = 26%), the episode rate of URTIs (rate ratio: 0.72; 95% CI: 0.60 to 0.86; P=0.0002; I2 = 99%), and the mean duration of one episode of URTI (MD: −2.66; 95% CI: −4.79 to −0.54; P=0.01; I2 = 80%). The adverse events of probiotics were mainly mild gastrointestinal symptoms. There were no significant differences in occurrence rate of adverse effects between probiotics intervention and placebo group (rate ratio: 1.01; 95% CI: 0.80 to 1.26; P=0.96; I2 = 99%). Conclusion. Low-quality evidence provides support that probiotics have potential efficacy for preventing URTI episodes in adults. More trials are required to confirm this conclusion.</abstract><cop>Cairo, Egypt</cop><pub>Hindawi Publishing Corporation</pub><pmid>33293995</pmid><doi>10.1155/2020/8734140</doi><tpages>8</tpages><orcidid>https://orcid.org/0000-0002-0916-3661</orcidid><orcidid>https://orcid.org/0000-0002-6603-695X</orcidid><oa>free_for_read</oa></addata></record> |
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| subjects | Bias Clinical trials Infections Meta-analysis Prevention Probiotics Respiratory tract diseases Respiratory tract infection Systematic review |
| title | Probiotics for Preventing Upper Respiratory Tract Infections in Adults: A Systematic Review and Meta-Analysis of Randomized Controlled Trials |
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