Monocyte CD169 expression as a biomarker in the early diagnosis of COVID-19
We assessed the expression of CD169, a type I interferon-inducible receptor, on monocytes (mCD169) in 53 adult patients admitted to the hospital during the COVID-19 outbreak for a suspicion of SARS-CoV-2 infection. mCD169 was strongly overexpressed in 30 out of 32 (93.7%) confirmed COVID-19 cases, c...
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| Veröffentlicht in: | The Journal of infectious diseases 2021-02, Vol.223 (4), p.562-567 |
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| container_end_page | 567 |
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| container_title | The Journal of infectious diseases |
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| creator | Bedin, Anne-Sophie Makinson, Alain Picot, Marie-Christine Mennechet, Frank Malergue, Fabrice Pisoni, Amandine Nyiramigisha, Esperance Montagnier, Lise Bollore, Karine Debiesse, Ségolène Morquin, David Veyrenche, Nicolas Renault, Constance Foulongne, Vincent Bret, Caroline Bourdin, Arnaud Le Moing, Vincent van de Perre, Philippe Tuaillon, Edouard |
| description | We assessed the expression of CD169, a type I interferon-inducible receptor, on monocytes (mCD169) in 53 adult patients admitted to the hospital during the COVID-19 outbreak for a suspicion of SARS-CoV-2 infection. mCD169 was strongly overexpressed in 30 out of 32 (93.7%) confirmed COVID-19 cases, compared to three out of 21 (14.3%) patients in whom the diagnosis of COVID-19 was finally ruled out. mCD169 was associated with the plasma interferon alpha level and thrombocytopenia. mCD169 testing may be helpful for the rapid triage of suspected COVID-19 patients during an outbreak. |
| doi_str_mv | 10.1093/infdis/jiaa724 |
| format | Article |
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| source | Oxford University Press Journals All Titles (1996-Current); Alma/SFX Local Collection |
| subjects | Brief Report Life Sciences |
| title | Monocyte CD169 expression as a biomarker in the early diagnosis of COVID-19 |
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