Platelet-derived calpain cleaves the endothelial protease-activated receptor 1 to induce vascular inflammation in diabetes

Diabetes mellitus is a major risk factor for cardiovascular disease. Platelets from diabetic patients are hyperreactive and release microparticles that carry activated cysteine proteases or calpains. Whether platelet-derived calpains contribute to the development of vascular complications in diabete...

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Veröffentlicht in:	Basic research in cardiology 2020-12, Vol.115 (6), p.75-75, Article 75
Hauptverfasser:	Kyselova, Anastasia, Elgheznawy, Amro, Wittig, Ilka, Heidler, Juliana, Mann, Alexander W., Ruf, Wolfram, Fleming, Ingrid, Randriamboavonjy, Voahanginirina
Format:	Artikel
Sprache:	eng
Schlagworte:	Adhesion Calpain Cardiology Cardiovascular diseases Cell surface Complications Diabetes Diabetes mellitus Endothelial cells Health risks Intercellular adhesion molecule 1 Medicine Medicine & Public Health Microparticles Monocytes Original Contribution Platelets Protease Protein C Proteinase-activated receptor 1 Receptors Risk analysis Risk factors Rodents Tumor necrosis factor-TNF Tumor necrosis factor-α
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