Urinary expression of long non-coding RNA TUG1 in non-diabetic patients with glomerulonephritides
Metabolic alterations serve a significant role in the pathogenesis of kidney disease. Long non-coding RNA (lncRNA) taurine upregulated gene 1 (TUG1) is a known regulator of podocyte health and mitochondrial biogenesis. Although TUG1 protects against podocyte loss in models of diabetic nephropathy, i...
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| Veröffentlicht in: | Biomedical reports 2021-01, Vol.14 (1), p.17-17, Article 17 |
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| description | Metabolic alterations serve a significant role in the pathogenesis of kidney disease. Long non-coding RNA (lncRNA) taurine upregulated gene 1 (TUG1) is a known regulator of podocyte health and mitochondrial biogenesis. Although TUG1 protects against podocyte loss in models of diabetic nephropathy, it is unknown if urinary TUG1 expression is associated with clinical and histopathological findings in non-diabetic patients diagnosed with glomerulonephritides. In the present study, the expression of TUG1, podocyte-specific markers (nephrin and podocin) and mitochondrial biogenesis-associated mRNAs (transcription factor A mitochondrial, cytochrome C oxidase subunit 5A and peroxisome proliferator-activated receptor γ coactivator 1α) were examined in urinary sediment of non-diabetic patients with biopsy-confirmed glomerulonephritides and healthy controls. Urinary expression of TUG1 was significantly lower in patients with glomerulonephritides, particularly those diagnosed with Focal Segmental Glomerulosclerosis (FSGS). Furthermore, TUG1 levels were associated with urinary expression of podocyte-specific markers and mRNAs associated with mitochondrial biogenesis. Loss of TUG1 expression in urinary sediment was strongly associated with FSGS, highlighting the potential of this lncRNA and its mitochondrial biogenesis-associated targets as non-invasive biomarkers of assessing podocytopathy. |
| doi_str_mv | 10.3892/br.2020.1393 |
| format | Article |
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Long non-coding RNA (lncRNA) taurine upregulated gene 1 (TUG1) is a known regulator of podocyte health and mitochondrial biogenesis. Although TUG1 protects against podocyte loss in models of diabetic nephropathy, it is unknown if urinary TUG1 expression is associated with clinical and histopathological findings in non-diabetic patients diagnosed with glomerulonephritides. In the present study, the expression of TUG1, podocyte-specific markers (nephrin and podocin) and mitochondrial biogenesis-associated mRNAs (transcription factor A mitochondrial, cytochrome C oxidase subunit 5A and peroxisome proliferator-activated receptor γ coactivator 1α) were examined in urinary sediment of non-diabetic patients with biopsy-confirmed glomerulonephritides and healthy controls. Urinary expression of TUG1 was significantly lower in patients with glomerulonephritides, particularly those diagnosed with Focal Segmental Glomerulosclerosis (FSGS). Furthermore, TUG1 levels were associated with urinary expression of podocyte-specific markers and mRNAs associated with mitochondrial biogenesis. Loss of TUG1 expression in urinary sediment was strongly associated with FSGS, highlighting the potential of this lncRNA and its mitochondrial biogenesis-associated targets as non-invasive biomarkers of assessing podocytopathy.</description><identifier>ISSN: 2049-9434</identifier><identifier>EISSN: 2049-9442</identifier><identifier>DOI: 10.3892/br.2020.1393</identifier><identifier>PMID: 33365127</identifier><language>eng</language><publisher>England: Spandidos Publications</publisher><subject>Biomarkers ; Biopsy ; Biosynthesis ; Cytochrome-c oxidase ; Cytochromes ; Diabetes ; Diabetes mellitus ; Diabetic nephropathies ; Diabetics ; Disease ; Gene expression ; Genes ; Health aspects ; Hospitals ; Kidney diseases ; Medical research ; Medicine, Experimental ; MicroRNAs ; Mitochondria ; Nephropathy ; Non-coding RNA ; Oxidases ; Pathogenesis ; Patients ; Ribonucleic acid ; RNA ; Statistical analysis ; Taurine ; Urine</subject><ispartof>Biomedical reports, 2021-01, Vol.14 (1), p.17-17, Article 17</ispartof><rights>Copyright © 2020, Spandidos Publications.</rights><rights>COPYRIGHT 2021 Spandidos Publications</rights><rights>Copyright Spandidos Publications UK Ltd. 2021</rights><rights>Copyright © 2020, Spandidos Publications 2020</rights><oa>free_for_read</oa><woscitedreferencessubscribed>false</woscitedreferencessubscribed><citedby>FETCH-LOGICAL-c479t-1a394ca8555e19f269b864ef811b6682398a51b13114b206b4e14f4a6aa944383</citedby><orcidid>0000-0002-9136-8382</orcidid></display><links><openurl>$$Topenurl_article</openurl><openurlfulltext>$$Topenurlfull_article</openurlfulltext><thumbnail>$$Tsyndetics_thumb_exl</thumbnail><linktopdf>$$Uhttps://www.ncbi.nlm.nih.gov/pmc/articles/PMC7716717/pdf/$$EPDF$$P50$$Gpubmedcentral$$H</linktopdf><linktohtml>$$Uhttps://www.ncbi.nlm.nih.gov/pmc/articles/PMC7716717/$$EHTML$$P50$$Gpubmedcentral$$H</linktohtml><link.rule.ids>230,314,727,780,784,885,27924,27925,53791,53793</link.rule.ids><backlink>$$Uhttps://www.ncbi.nlm.nih.gov/pubmed/33365127$$D View this record in MEDLINE/PubMed$$Hfree_for_read</backlink></links><search><creatorcontrib>Salazar-Torres, Fernando Javier</creatorcontrib><creatorcontrib>Medina-Perez, Miguel</creatorcontrib><creatorcontrib>Melo, Zesergio</creatorcontrib><creatorcontrib>Mendoza-Cerpa, Claudia</creatorcontrib><creatorcontrib>Echavarria, Raquel</creatorcontrib><title>Urinary expression of long non-coding RNA TUG1 in non-diabetic patients with glomerulonephritides</title><title>Biomedical reports</title><addtitle>Biomed Rep</addtitle><description>Metabolic alterations serve a significant role in the pathogenesis of kidney disease. Long non-coding RNA (lncRNA) taurine upregulated gene 1 (TUG1) is a known regulator of podocyte health and mitochondrial biogenesis. Although TUG1 protects against podocyte loss in models of diabetic nephropathy, it is unknown if urinary TUG1 expression is associated with clinical and histopathological findings in non-diabetic patients diagnosed with glomerulonephritides. In the present study, the expression of TUG1, podocyte-specific markers (nephrin and podocin) and mitochondrial biogenesis-associated mRNAs (transcription factor A mitochondrial, cytochrome C oxidase subunit 5A and peroxisome proliferator-activated receptor γ coactivator 1α) were examined in urinary sediment of non-diabetic patients with biopsy-confirmed glomerulonephritides and healthy controls. Urinary expression of TUG1 was significantly lower in patients with glomerulonephritides, particularly those diagnosed with Focal Segmental Glomerulosclerosis (FSGS). Furthermore, TUG1 levels were associated with urinary expression of podocyte-specific markers and mRNAs associated with mitochondrial biogenesis. Loss of TUG1 expression in urinary sediment was strongly associated with FSGS, highlighting the potential of this lncRNA and its mitochondrial biogenesis-associated targets as non-invasive biomarkers of assessing podocytopathy.</description><subject>Biomarkers</subject><subject>Biopsy</subject><subject>Biosynthesis</subject><subject>Cytochrome-c oxidase</subject><subject>Cytochromes</subject><subject>Diabetes</subject><subject>Diabetes mellitus</subject><subject>Diabetic nephropathies</subject><subject>Diabetics</subject><subject>Disease</subject><subject>Gene expression</subject><subject>Genes</subject><subject>Health aspects</subject><subject>Hospitals</subject><subject>Kidney diseases</subject><subject>Medical research</subject><subject>Medicine, Experimental</subject><subject>MicroRNAs</subject><subject>Mitochondria</subject><subject>Nephropathy</subject><subject>Non-coding RNA</subject><subject>Oxidases</subject><subject>Pathogenesis</subject><subject>Patients</subject><subject>Ribonucleic acid</subject><subject>RNA</subject><subject>Statistical analysis</subject><subject>Taurine</subject><subject>Urine</subject><issn>2049-9434</issn><issn>2049-9442</issn><fulltext>true</fulltext><rsrctype>article</rsrctype><creationdate>2021</creationdate><recordtype>article</recordtype><sourceid>AFKRA</sourceid><sourceid>AZQEC</sourceid><sourceid>BENPR</sourceid><sourceid>CCPQU</sourceid><sourceid>DWQXO</sourceid><sourceid>GNUQQ</sourceid><recordid>eNptksFvFSEQxonR2Kb25tmQePHgPhlgWbiYvDRaTRpNTN-ZwC77Hs0urLBb9b-XtfVpjXBgMvzmYz4yCD0HsmFS0Tc2bSihZANMsUfolBKuKsU5fXyMGT9B5znfkLJUQ2gtn6ITxpiogTanyOySDyb9wO77lFzOPgYcezzEsMchhqqNnS_hl09bfL27BOzDr3TnjXWzb_FkZu_CnPE3Px_wfoijS0updtMh-dl3Lj9DT3ozZHd-f56h3ft31xcfqqvPlx8vtldVyxs1V2CY4q2RdV07UD0VykrBXS8BrBCSMiVNDRYYALeUCMsd8J4bYUwxzCQ7Q2_vdKfFjq5rS1fJDHpKfiz-dDReP7wJ_qD38VY3DYgGmiLw6l4gxa-Ly7MefW7dMJjg4pI15Q0rXUi1oi__QW_ikkKxVyjRSCAU2B9qbwanfehjebddRfVWcAFAQJBCbf5Dld250bflJ3tf8g8KXt8VtCnmnFx_9AhEr1OhbdLrVOh1Kgr-4u9_OcK_Z4D9BGSHsF8</recordid><startdate>20210101</startdate><enddate>20210101</enddate><creator>Salazar-Torres, Fernando Javier</creator><creator>Medina-Perez, Miguel</creator><creator>Melo, Zesergio</creator><creator>Mendoza-Cerpa, Claudia</creator><creator>Echavarria, Raquel</creator><general>Spandidos Publications</general><general>Spandidos Publications UK Ltd</general><general>D.A. 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Long non-coding RNA (lncRNA) taurine upregulated gene 1 (TUG1) is a known regulator of podocyte health and mitochondrial biogenesis. Although TUG1 protects against podocyte loss in models of diabetic nephropathy, it is unknown if urinary TUG1 expression is associated with clinical and histopathological findings in non-diabetic patients diagnosed with glomerulonephritides. In the present study, the expression of TUG1, podocyte-specific markers (nephrin and podocin) and mitochondrial biogenesis-associated mRNAs (transcription factor A mitochondrial, cytochrome C oxidase subunit 5A and peroxisome proliferator-activated receptor γ coactivator 1α) were examined in urinary sediment of non-diabetic patients with biopsy-confirmed glomerulonephritides and healthy controls. Urinary expression of TUG1 was significantly lower in patients with glomerulonephritides, particularly those diagnosed with Focal Segmental Glomerulosclerosis (FSGS). Furthermore, TUG1 levels were associated with urinary expression of podocyte-specific markers and mRNAs associated with mitochondrial biogenesis. Loss of TUG1 expression in urinary sediment was strongly associated with FSGS, highlighting the potential of this lncRNA and its mitochondrial biogenesis-associated targets as non-invasive biomarkers of assessing podocytopathy.</abstract><cop>England</cop><pub>Spandidos Publications</pub><pmid>33365127</pmid><doi>10.3892/br.2020.1393</doi><tpages>1</tpages><orcidid>https://orcid.org/0000-0002-9136-8382</orcidid><oa>free_for_read</oa></addata></record> |
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| subjects | Biomarkers Biopsy Biosynthesis Cytochrome-c oxidase Cytochromes Diabetes Diabetes mellitus Diabetic nephropathies Diabetics Disease Gene expression Genes Health aspects Hospitals Kidney diseases Medical research Medicine, Experimental MicroRNAs Mitochondria Nephropathy Non-coding RNA Oxidases Pathogenesis Patients Ribonucleic acid RNA Statistical analysis Taurine Urine |
| title | Urinary expression of long non-coding RNA TUG1 in non-diabetic patients with glomerulonephritides |
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