Metformin induces apoptosis and inhibits migration by activating the AMPK/p53 axis and suppressing PI3K/AKT signaling in human cervical cancer cells

Human cervical cancer is the fourth most common malignancy among women worldwide, and it is expected to result in 460,000 deaths per year by 2040. Moreover, patients with cervical cancer often display drug resistance and severe side effects; therefore, the development of effective novel chemotherape...

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Veröffentlicht in:	Molecular medicine reports 2021-01, Vol.23 (1), Article 88
Hauptverfasser:	Chen, Ya-Hui, Yang, Shun-Fa, Yang, Chueh-Ko, Tsai, Horng-Der, Chen, Tze-Ho, Chou, Ming-Chih, Hsiao, Yi-Hsuan
Format:	Artikel
Sprache:	eng
Schlagworte:	1-Phosphatidylinositol 3-kinase AKT protein AMP AMP-activated protein kinase AMP-Activated Protein Kinases - genetics AMP-Activated Protein Kinases - metabolism Antidiabetics Apoptosis Apoptosis - drug effects Apoptosis - genetics Breast cancer Cancer therapies Cell adhesion & migration Cell cycle Cell death Cell migration Cell Movement - drug effects Cell Movement - genetics Cell viability Cervical cancer Cervix Chemotherapy Development and progression Diabetes mellitus (non-insulin dependent) Drug resistance Drug therapy Female Growth factors Health aspects HeLa Cells Humans Insulin Kinases Laboratories Malignancy Membranes Metformin Metformin - pharmacology Ovaries p53 Protein Pancreatic cancer Phosphatidylinositol 3-Kinases - genetics Phosphatidylinositol 3-Kinases - metabolism Phosphorylation Physiological aspects Prostate Protein kinases Proteins Proto-Oncogene Proteins c-akt - genetics Proto-Oncogene Proteins c-akt - metabolism Signal transduction Signal Transduction - drug effects Signal Transduction - genetics Tumor cell lines Tumor proteins Tumor suppressor genes Tumor Suppressor Protein p53 - genetics Tumor Suppressor Protein p53 - metabolism Tumors Uterine Cervical Neoplasms - drug therapy Uterine Cervical Neoplasms - genetics Uterine Cervical Neoplasms - metabolism Uterine Cervical Neoplasms - pathology
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