Biomechanical properties of the rat sclera obtained with inverse finite element modeling
It is widely accepted that biomechanics plays an important role in glaucoma pathophysiology, but the mechanisms involved are largely unknown. Rats are a common animal model of glaucoma, and finite element models are being developed to provide much-needed insight into the biomechanical environment of...
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description | It is widely accepted that biomechanics plays an important role in glaucoma pathophysiology, but the mechanisms involved are largely unknown. Rats are a common animal model of glaucoma, and finite element models are being developed to provide much-needed insight into the biomechanical environment of the posterior rat eye. However, material properties of rat ocular tissues, including the sclera, are currently unknown. Since the sclera plays a major role in posterior ocular biomechanics, our goal was to use inverse finite element modeling to extract rat scleral material properties. We first used digital image correlation to measure scleral surface displacement during whole-globe inflation testing. We modeled the sclera as a nonlinear material with embedded collagen fibers and then fit modeled displacements to experimental data using a differential evolution algorithm. Subject-specific models were constructed in which 3 parameters described the stiffness of the ground substance and collagen fibers in the posterior eye, and 16 parameters defined the primary orientation and alignment of fibers within eight scleral sub-regions. We successfully extracted scleral material properties for eight rat eyes. Model displacements recreated general patterns of the experimental displacements but did not always match local patterns. The fiber directions and fiber concentration parameters were highly variable, but on average, fibers were aligned circumferentially and were more aligned in the peripapillary sclera than in the peripheral sclera. The material properties determined here will be used to inform future finite element models of the rat posterior eye with the goal of elucidating the role of biomechanics in glaucoma pathophysiology. |
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We modeled the sclera as a nonlinear material with embedded collagen fibers and then fit modeled displacements to experimental data using a differential evolution algorithm. Subject-specific models were constructed in which 3 parameters described the stiffness of the ground substance and collagen fibers in the posterior eye, and 16 parameters defined the primary orientation and alignment of fibers within eight scleral sub-regions. We successfully extracted scleral material properties for eight rat eyes. Model displacements recreated general patterns of the experimental displacements but did not always match local patterns. The fiber directions and fiber concentration parameters were highly variable, but on average, fibers were aligned circumferentially and were more aligned in the peripapillary sclera than in the peripheral sclera. The material properties determined here will be used to inform future finite element models of the rat posterior eye with the goal of elucidating the role of biomechanics in glaucoma pathophysiology.</description><identifier>ISSN: 1617-7959</identifier><identifier>EISSN: 1617-7940</identifier><identifier>DOI: 10.1007/s10237-020-01333-4</identifier><identifier>PMID: 32361821</identifier><language>eng</language><publisher>Berlin/Heidelberg: Springer Berlin Heidelberg</publisher><subject>Algorithms ; Animal models ; Animals ; Anisotropy ; Biological and Medical Physics ; Biomechanical Phenomena ; Biomechanics ; Biomedical Engineering and Bioengineering ; Biophysics ; Collagen ; Digital imaging ; Disease Models, Animal ; Displacement ; Elastic Modulus ; Engineering ; Evolutionary algorithms ; Evolutionary computation ; Extracellular Matrix ; Eye ; Eye (anatomy) ; Fibers ; Finite Element Analysis ; Finite element method ; Glaucoma ; Glaucoma - physiopathology ; Image Processing, Computer-Assisted ; Intraocular Pressure ; Male ; Material properties ; Mathematical models ; Mechanical properties ; Modelling ; Original Paper ; Parameters ; Pathophysiology ; Rats ; Sclera - diagnostic imaging ; Sclera - physiopathology ; Stiffness ; Theoretical and Applied Mechanics ; Tomography, Optical Coherence - methods</subject><ispartof>Biomechanics and modeling in mechanobiology, 2020-12, Vol.19 (6), p.2195-2212</ispartof><rights>Springer-Verlag GmbH Germany, part of Springer Nature 2020</rights><rights>Springer-Verlag GmbH Germany, part of Springer Nature 2020.</rights><lds50>peer_reviewed</lds50><oa>free_for_read</oa><woscitedreferencessubscribed>false</woscitedreferencessubscribed><citedby>FETCH-LOGICAL-c474t-788546034f5e4b44b58b4a5f5b849fdc88125ab5732bd123ba15442c300aa8183</citedby><cites>FETCH-LOGICAL-c474t-788546034f5e4b44b58b4a5f5b849fdc88125ab5732bd123ba15442c300aa8183</cites><orcidid>0000-0002-4766-8900 ; 0000-0001-6110-3052</orcidid></display><links><openurl>$$Topenurl_article</openurl><openurlfulltext>$$Topenurlfull_article</openurlfulltext><thumbnail>$$Tsyndetics_thumb_exl</thumbnail><linktopdf>$$Uhttps://link.springer.com/content/pdf/10.1007/s10237-020-01333-4$$EPDF$$P50$$Gspringer$$H</linktopdf><linktohtml>$$Uhttps://link.springer.com/10.1007/s10237-020-01333-4$$EHTML$$P50$$Gspringer$$H</linktohtml><link.rule.ids>230,314,780,784,885,27924,27925,41488,42557,51319</link.rule.ids><backlink>$$Uhttps://www.ncbi.nlm.nih.gov/pubmed/32361821$$D View this record in MEDLINE/PubMed$$Hfree_for_read</backlink></links><search><creatorcontrib>Schwaner, Stephen A.</creatorcontrib><creatorcontrib>Hannon, Bailey G.</creatorcontrib><creatorcontrib>Feola, Andrew J.</creatorcontrib><creatorcontrib>Ethier, C. Ross</creatorcontrib><title>Biomechanical properties of the rat sclera obtained with inverse finite element modeling</title><title>Biomechanics and modeling in mechanobiology</title><addtitle>Biomech Model Mechanobiol</addtitle><addtitle>Biomech Model Mechanobiol</addtitle><description>It is widely accepted that biomechanics plays an important role in glaucoma pathophysiology, but the mechanisms involved are largely unknown. Rats are a common animal model of glaucoma, and finite element models are being developed to provide much-needed insight into the biomechanical environment of the posterior rat eye. However, material properties of rat ocular tissues, including the sclera, are currently unknown. Since the sclera plays a major role in posterior ocular biomechanics, our goal was to use inverse finite element modeling to extract rat scleral material properties. We first used digital image correlation to measure scleral surface displacement during whole-globe inflation testing. We modeled the sclera as a nonlinear material with embedded collagen fibers and then fit modeled displacements to experimental data using a differential evolution algorithm. Subject-specific models were constructed in which 3 parameters described the stiffness of the ground substance and collagen fibers in the posterior eye, and 16 parameters defined the primary orientation and alignment of fibers within eight scleral sub-regions. We successfully extracted scleral material properties for eight rat eyes. Model displacements recreated general patterns of the experimental displacements but did not always match local patterns. The fiber directions and fiber concentration parameters were highly variable, but on average, fibers were aligned circumferentially and were more aligned in the peripapillary sclera than in the peripheral sclera. The material properties determined here will be used to inform future finite element models of the rat posterior eye with the goal of elucidating the role of biomechanics in glaucoma pathophysiology.</description><subject>Algorithms</subject><subject>Animal models</subject><subject>Animals</subject><subject>Anisotropy</subject><subject>Biological and Medical Physics</subject><subject>Biomechanical Phenomena</subject><subject>Biomechanics</subject><subject>Biomedical Engineering and Bioengineering</subject><subject>Biophysics</subject><subject>Collagen</subject><subject>Digital imaging</subject><subject>Disease Models, Animal</subject><subject>Displacement</subject><subject>Elastic Modulus</subject><subject>Engineering</subject><subject>Evolutionary algorithms</subject><subject>Evolutionary computation</subject><subject>Extracellular Matrix</subject><subject>Eye</subject><subject>Eye (anatomy)</subject><subject>Fibers</subject><subject>Finite Element Analysis</subject><subject>Finite element method</subject><subject>Glaucoma</subject><subject>Glaucoma - physiopathology</subject><subject>Image Processing, Computer-Assisted</subject><subject>Intraocular Pressure</subject><subject>Male</subject><subject>Material properties</subject><subject>Mathematical models</subject><subject>Mechanical properties</subject><subject>Modelling</subject><subject>Original Paper</subject><subject>Parameters</subject><subject>Pathophysiology</subject><subject>Rats</subject><subject>Sclera - diagnostic imaging</subject><subject>Sclera - physiopathology</subject><subject>Stiffness</subject><subject>Theoretical and Applied Mechanics</subject><subject>Tomography, Optical Coherence - methods</subject><issn>1617-7959</issn><issn>1617-7940</issn><fulltext>true</fulltext><rsrctype>article</rsrctype><creationdate>2020</creationdate><recordtype>article</recordtype><sourceid>EIF</sourceid><sourceid>ABUWG</sourceid><sourceid>AFKRA</sourceid><sourceid>AZQEC</sourceid><sourceid>BENPR</sourceid><sourceid>CCPQU</sourceid><sourceid>DWQXO</sourceid><sourceid>GNUQQ</sourceid><recordid>eNp9kU1rFTEUhoNU7If-ARcScONmNJ-TzKagxbZCwY2Cu5BkztybMpPcJrkt_nvT3nr9WHSVwHnOe87hQeg1Je8pIepDoYRx1RFGOkI55514ho5oT1WnBkEO9n85HKLjUq5JI7nmL9AhZ7ynmtEj9ONTSAv4tY3B2xlvctpArgEKThOua8DZVlz8DNni5KoNEUZ8F-oah3gLuQCeQgwVMMywQKx4SSPMIa5eoueTnQu8enxP0Pfzz9_OLrurrxdfzj5edV4oUTultRQ94WKSIJwQTmonrJyk02KYRq81ZdI6qThzI2XcWSqFYJ4TYq2mmp-g013uZusWGH3bIdvZbHJYbP5pkg3m30oMa7NKt0Yp2rNetoB3jwE53WyhVLOE4mGebYS0LYbxQVM5MHk_6-1_6HXa5tjOM0w2bGBMkkaxHeVzKiXDtF-GEnMvzuzEmabDPIgzojW9-fuMfctvUw3gO6C0UlxB_jP7idhf6p6j9Q</recordid><startdate>20201201</startdate><enddate>20201201</enddate><creator>Schwaner, Stephen A.</creator><creator>Hannon, Bailey G.</creator><creator>Feola, Andrew J.</creator><creator>Ethier, C. 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Ross</author></sort><facets><frbrtype>5</frbrtype><frbrgroupid>cdi_FETCH-LOGICAL-c474t-788546034f5e4b44b58b4a5f5b849fdc88125ab5732bd123ba15442c300aa8183</frbrgroupid><rsrctype>articles</rsrctype><prefilter>articles</prefilter><language>eng</language><creationdate>2020</creationdate><topic>Algorithms</topic><topic>Animal models</topic><topic>Animals</topic><topic>Anisotropy</topic><topic>Biological and Medical Physics</topic><topic>Biomechanical Phenomena</topic><topic>Biomechanics</topic><topic>Biomedical Engineering and Bioengineering</topic><topic>Biophysics</topic><topic>Collagen</topic><topic>Digital imaging</topic><topic>Disease Models, Animal</topic><topic>Displacement</topic><topic>Elastic Modulus</topic><topic>Engineering</topic><topic>Evolutionary algorithms</topic><topic>Evolutionary computation</topic><topic>Extracellular Matrix</topic><topic>Eye</topic><topic>Eye (anatomy)</topic><topic>Fibers</topic><topic>Finite Element Analysis</topic><topic>Finite element method</topic><topic>Glaucoma</topic><topic>Glaucoma - physiopathology</topic><topic>Image Processing, Computer-Assisted</topic><topic>Intraocular Pressure</topic><topic>Male</topic><topic>Material properties</topic><topic>Mathematical models</topic><topic>Mechanical properties</topic><topic>Modelling</topic><topic>Original Paper</topic><topic>Parameters</topic><topic>Pathophysiology</topic><topic>Rats</topic><topic>Sclera - diagnostic imaging</topic><topic>Sclera - physiopathology</topic><topic>Stiffness</topic><topic>Theoretical and Applied Mechanics</topic><topic>Tomography, Optical Coherence - methods</topic><toplevel>peer_reviewed</toplevel><toplevel>online_resources</toplevel><creatorcontrib>Schwaner, Stephen A.</creatorcontrib><creatorcontrib>Hannon, Bailey G.</creatorcontrib><creatorcontrib>Feola, Andrew J.</creatorcontrib><creatorcontrib>Ethier, C. 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Ross</au><format>journal</format><genre>article</genre><ristype>JOUR</ristype><atitle>Biomechanical properties of the rat sclera obtained with inverse finite element modeling</atitle><jtitle>Biomechanics and modeling in mechanobiology</jtitle><stitle>Biomech Model Mechanobiol</stitle><addtitle>Biomech Model Mechanobiol</addtitle><date>2020-12-01</date><risdate>2020</risdate><volume>19</volume><issue>6</issue><spage>2195</spage><epage>2212</epage><pages>2195-2212</pages><issn>1617-7959</issn><eissn>1617-7940</eissn><abstract>It is widely accepted that biomechanics plays an important role in glaucoma pathophysiology, but the mechanisms involved are largely unknown. Rats are a common animal model of glaucoma, and finite element models are being developed to provide much-needed insight into the biomechanical environment of the posterior rat eye. However, material properties of rat ocular tissues, including the sclera, are currently unknown. Since the sclera plays a major role in posterior ocular biomechanics, our goal was to use inverse finite element modeling to extract rat scleral material properties. We first used digital image correlation to measure scleral surface displacement during whole-globe inflation testing. We modeled the sclera as a nonlinear material with embedded collagen fibers and then fit modeled displacements to experimental data using a differential evolution algorithm. Subject-specific models were constructed in which 3 parameters described the stiffness of the ground substance and collagen fibers in the posterior eye, and 16 parameters defined the primary orientation and alignment of fibers within eight scleral sub-regions. We successfully extracted scleral material properties for eight rat eyes. Model displacements recreated general patterns of the experimental displacements but did not always match local patterns. The fiber directions and fiber concentration parameters were highly variable, but on average, fibers were aligned circumferentially and were more aligned in the peripapillary sclera than in the peripheral sclera. The material properties determined here will be used to inform future finite element models of the rat posterior eye with the goal of elucidating the role of biomechanics in glaucoma pathophysiology.</abstract><cop>Berlin/Heidelberg</cop><pub>Springer Berlin Heidelberg</pub><pmid>32361821</pmid><doi>10.1007/s10237-020-01333-4</doi><tpages>18</tpages><orcidid>https://orcid.org/0000-0002-4766-8900</orcidid><orcidid>https://orcid.org/0000-0001-6110-3052</orcidid><oa>free_for_read</oa></addata></record> |
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subjects | Algorithms Animal models Animals Anisotropy Biological and Medical Physics Biomechanical Phenomena Biomechanics Biomedical Engineering and Bioengineering Biophysics Collagen Digital imaging Disease Models, Animal Displacement Elastic Modulus Engineering Evolutionary algorithms Evolutionary computation Extracellular Matrix Eye Eye (anatomy) Fibers Finite Element Analysis Finite element method Glaucoma Glaucoma - physiopathology Image Processing, Computer-Assisted Intraocular Pressure Male Material properties Mathematical models Mechanical properties Modelling Original Paper Parameters Pathophysiology Rats Sclera - diagnostic imaging Sclera - physiopathology Stiffness Theoretical and Applied Mechanics Tomography, Optical Coherence - methods |
title | Biomechanical properties of the rat sclera obtained with inverse finite element modeling |
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