Long non-coding RNA FOXD1-AS1 promotes the progression and glycolysis of nasopharyngeal carcinoma by sustaining FOXD1 expression
Long non-coding RNAs (lncRNAs) play a vital role in the progression of several cancers, including nasopharyngeal carcinoma (NPC). However, the mechanism of lncRNA involvement in the progression of NPC remains to be elucidated. Hence, we conducted in vivo and in vitro experiments to determine the mol...
Gespeichert in:
| Veröffentlicht in: | American journal of cancer research 2020-01, Vol.10 (11), p.3686-3704 |
|---|---|
| Hauptverfasser: | , , , , , , , , , , , , , , , |
| Format: | Artikel |
| Sprache: | eng |
| Schlagworte: | |
| Online-Zugang: | Volltext |
| Tags: |
Tag hinzufügen
Keine Tags, Fügen Sie den ersten Tag hinzu!
|
| container_end_page | 3704 |
|---|---|
| container_issue | 11 |
| container_start_page | 3686 |
| container_title | American journal of cancer research |
| container_volume | 10 |
| creator | Wang, Zhanwang Cheng, Yaxin Zhu, Yuxing Hu, Xueying Jin, Yi Gong, Lian Xiao, Mengqing Xiang, Liang Zeng, Qinghai Liu, Jianye Chen, Xingyu Zhang, Yeyu Liu, Xiaoming Deng, Liping He, Dong Cao, Ke |
| description | Long non-coding RNAs (lncRNAs) play a vital role in the progression of several cancers, including nasopharyngeal carcinoma (NPC). However, the mechanism of lncRNA involvement in the progression of NPC remains to be elucidated. Hence, we conducted in vivo and in vitro experiments to determine the molecular mechanism of FOXD1-AS1. We found that FOXD1-AS1 was over-expressed in NPC cells and tissues, and was significantly associated with poor survival rate in patients with NPC. We also found that FOXD1-AS1 promotes cellular proliferation, migration, invasion, and glycolysis, and inhibits apoptosis by upregulating the expression of FOXD1. Furthermore, FOXD1 could transcriptionally up-regulate the expression of key glycolytic genes to promote the glycolysis levels of NPC. The identified FOXD1-AS1 may serve as a potential prognostic biomarker and therapeutic target for patients with NPC. |
| format | Article |
| fullrecord | <record><control><sourceid>proquest_pubme</sourceid><recordid>TN_cdi_pubmedcentral_primary_oai_pubmedcentral_nih_gov_7716144</recordid><sourceformat>XML</sourceformat><sourcesystem>PC</sourcesystem><sourcerecordid>2468660636</sourcerecordid><originalsourceid>FETCH-LOGICAL-p173t-31a5e4863a50f278459225872bc909d7cc0301fe5331f9ca25648b314ee1481f3</originalsourceid><addsrcrecordid>eNpVzk1Lw0AQBuAgii21_2GPXgLZz2QvQqlWhWLBD_C2bDaTdCXZjdlEzM2fbqo96FzmfRl4mJNoTjAXsZCpOP2TZ9EyhLdkGpZgyeR5NKOUSEYEnkdfW-8q5LyLjS_sFB8fVmize73G8eoJo7bzje8hoH4Ph1J1EIL1DmlXoKoeja_HYAPyJXI6-Havu9FVoGtkdGes841G-YjCEHpt3cH_sRF8tkfpIjordR1gedyL6GVz87y-i7e72_v1ahu3OKV9TLHmwDJBNU9KkmaMS0J4lpLcyEQWqTEJTXAJnFJcSqMJFyzLKWYAmGW4pIvo6tdth7yBwoDrO12rtrPN9LPy2qr_F2f3qvIfKk2xwIxNwOUR6Pz7AKFXjQ0G6lo78ENQhIlMiERQQb8BUbF3ww</addsrcrecordid><sourcetype>Open Access Repository</sourcetype><iscdi>true</iscdi><recordtype>article</recordtype><pqid>2468660636</pqid></control><display><type>article</type><title>Long non-coding RNA FOXD1-AS1 promotes the progression and glycolysis of nasopharyngeal carcinoma by sustaining FOXD1 expression</title><source>Elektronische Zeitschriftenbibliothek - Frei zugängliche E-Journals</source><source>PubMed Central</source><creator>Wang, Zhanwang ; Cheng, Yaxin ; Zhu, Yuxing ; Hu, Xueying ; Jin, Yi ; Gong, Lian ; Xiao, Mengqing ; Xiang, Liang ; Zeng, Qinghai ; Liu, Jianye ; Chen, Xingyu ; Zhang, Yeyu ; Liu, Xiaoming ; Deng, Liping ; He, Dong ; Cao, Ke</creator><creatorcontrib>Wang, Zhanwang ; Cheng, Yaxin ; Zhu, Yuxing ; Hu, Xueying ; Jin, Yi ; Gong, Lian ; Xiao, Mengqing ; Xiang, Liang ; Zeng, Qinghai ; Liu, Jianye ; Chen, Xingyu ; Zhang, Yeyu ; Liu, Xiaoming ; Deng, Liping ; He, Dong ; Cao, Ke</creatorcontrib><description>Long non-coding RNAs (lncRNAs) play a vital role in the progression of several cancers, including nasopharyngeal carcinoma (NPC). However, the mechanism of lncRNA involvement in the progression of NPC remains to be elucidated. Hence, we conducted in vivo and in vitro experiments to determine the molecular mechanism of FOXD1-AS1. We found that FOXD1-AS1 was over-expressed in NPC cells and tissues, and was significantly associated with poor survival rate in patients with NPC. We also found that FOXD1-AS1 promotes cellular proliferation, migration, invasion, and glycolysis, and inhibits apoptosis by upregulating the expression of FOXD1. Furthermore, FOXD1 could transcriptionally up-regulate the expression of key glycolytic genes to promote the glycolysis levels of NPC. The identified FOXD1-AS1 may serve as a potential prognostic biomarker and therapeutic target for patients with NPC.</description><identifier>ISSN: 2156-6976</identifier><identifier>EISSN: 2156-6976</identifier><identifier>PMID: 33294261</identifier><language>eng</language><publisher>e-Century Publishing Corporation</publisher><subject>Original</subject><ispartof>American journal of cancer research, 2020-01, Vol.10 (11), p.3686-3704</ispartof><rights>AJCR Copyright © 2020 2020</rights><woscitedreferencessubscribed>false</woscitedreferencessubscribed></display><links><openurl>$$Topenurl_article</openurl><openurlfulltext>$$Topenurlfull_article</openurlfulltext><thumbnail>$$Tsyndetics_thumb_exl</thumbnail><linktopdf>$$Uhttps://www.ncbi.nlm.nih.gov/pmc/articles/PMC7716144/pdf/$$EPDF$$P50$$Gpubmedcentral$$H</linktopdf><linktohtml>$$Uhttps://www.ncbi.nlm.nih.gov/pmc/articles/PMC7716144/$$EHTML$$P50$$Gpubmedcentral$$H</linktohtml><link.rule.ids>230,314,727,780,784,885,53791,53793</link.rule.ids></links><search><creatorcontrib>Wang, Zhanwang</creatorcontrib><creatorcontrib>Cheng, Yaxin</creatorcontrib><creatorcontrib>Zhu, Yuxing</creatorcontrib><creatorcontrib>Hu, Xueying</creatorcontrib><creatorcontrib>Jin, Yi</creatorcontrib><creatorcontrib>Gong, Lian</creatorcontrib><creatorcontrib>Xiao, Mengqing</creatorcontrib><creatorcontrib>Xiang, Liang</creatorcontrib><creatorcontrib>Zeng, Qinghai</creatorcontrib><creatorcontrib>Liu, Jianye</creatorcontrib><creatorcontrib>Chen, Xingyu</creatorcontrib><creatorcontrib>Zhang, Yeyu</creatorcontrib><creatorcontrib>Liu, Xiaoming</creatorcontrib><creatorcontrib>Deng, Liping</creatorcontrib><creatorcontrib>He, Dong</creatorcontrib><creatorcontrib>Cao, Ke</creatorcontrib><title>Long non-coding RNA FOXD1-AS1 promotes the progression and glycolysis of nasopharyngeal carcinoma by sustaining FOXD1 expression</title><title>American journal of cancer research</title><description>Long non-coding RNAs (lncRNAs) play a vital role in the progression of several cancers, including nasopharyngeal carcinoma (NPC). However, the mechanism of lncRNA involvement in the progression of NPC remains to be elucidated. Hence, we conducted in vivo and in vitro experiments to determine the molecular mechanism of FOXD1-AS1. We found that FOXD1-AS1 was over-expressed in NPC cells and tissues, and was significantly associated with poor survival rate in patients with NPC. We also found that FOXD1-AS1 promotes cellular proliferation, migration, invasion, and glycolysis, and inhibits apoptosis by upregulating the expression of FOXD1. Furthermore, FOXD1 could transcriptionally up-regulate the expression of key glycolytic genes to promote the glycolysis levels of NPC. The identified FOXD1-AS1 may serve as a potential prognostic biomarker and therapeutic target for patients with NPC.</description><subject>Original</subject><issn>2156-6976</issn><issn>2156-6976</issn><fulltext>true</fulltext><rsrctype>article</rsrctype><creationdate>2020</creationdate><recordtype>article</recordtype><recordid>eNpVzk1Lw0AQBuAgii21_2GPXgLZz2QvQqlWhWLBD_C2bDaTdCXZjdlEzM2fbqo96FzmfRl4mJNoTjAXsZCpOP2TZ9EyhLdkGpZgyeR5NKOUSEYEnkdfW-8q5LyLjS_sFB8fVmize73G8eoJo7bzje8hoH4Ph1J1EIL1DmlXoKoeja_HYAPyJXI6-Havu9FVoGtkdGes841G-YjCEHpt3cH_sRF8tkfpIjordR1gedyL6GVz87y-i7e72_v1ahu3OKV9TLHmwDJBNU9KkmaMS0J4lpLcyEQWqTEJTXAJnFJcSqMJFyzLKWYAmGW4pIvo6tdth7yBwoDrO12rtrPN9LPy2qr_F2f3qvIfKk2xwIxNwOUR6Pz7AKFXjQ0G6lo78ENQhIlMiERQQb8BUbF3ww</recordid><startdate>20200101</startdate><enddate>20200101</enddate><creator>Wang, Zhanwang</creator><creator>Cheng, Yaxin</creator><creator>Zhu, Yuxing</creator><creator>Hu, Xueying</creator><creator>Jin, Yi</creator><creator>Gong, Lian</creator><creator>Xiao, Mengqing</creator><creator>Xiang, Liang</creator><creator>Zeng, Qinghai</creator><creator>Liu, Jianye</creator><creator>Chen, Xingyu</creator><creator>Zhang, Yeyu</creator><creator>Liu, Xiaoming</creator><creator>Deng, Liping</creator><creator>He, Dong</creator><creator>Cao, Ke</creator><general>e-Century Publishing Corporation</general><scope>7X8</scope><scope>5PM</scope></search><sort><creationdate>20200101</creationdate><title>Long non-coding RNA FOXD1-AS1 promotes the progression and glycolysis of nasopharyngeal carcinoma by sustaining FOXD1 expression</title><author>Wang, Zhanwang ; Cheng, Yaxin ; Zhu, Yuxing ; Hu, Xueying ; Jin, Yi ; Gong, Lian ; Xiao, Mengqing ; Xiang, Liang ; Zeng, Qinghai ; Liu, Jianye ; Chen, Xingyu ; Zhang, Yeyu ; Liu, Xiaoming ; Deng, Liping ; He, Dong ; Cao, Ke</author></sort><facets><frbrtype>5</frbrtype><frbrgroupid>cdi_FETCH-LOGICAL-p173t-31a5e4863a50f278459225872bc909d7cc0301fe5331f9ca25648b314ee1481f3</frbrgroupid><rsrctype>articles</rsrctype><prefilter>articles</prefilter><language>eng</language><creationdate>2020</creationdate><topic>Original</topic><toplevel>online_resources</toplevel><creatorcontrib>Wang, Zhanwang</creatorcontrib><creatorcontrib>Cheng, Yaxin</creatorcontrib><creatorcontrib>Zhu, Yuxing</creatorcontrib><creatorcontrib>Hu, Xueying</creatorcontrib><creatorcontrib>Jin, Yi</creatorcontrib><creatorcontrib>Gong, Lian</creatorcontrib><creatorcontrib>Xiao, Mengqing</creatorcontrib><creatorcontrib>Xiang, Liang</creatorcontrib><creatorcontrib>Zeng, Qinghai</creatorcontrib><creatorcontrib>Liu, Jianye</creatorcontrib><creatorcontrib>Chen, Xingyu</creatorcontrib><creatorcontrib>Zhang, Yeyu</creatorcontrib><creatorcontrib>Liu, Xiaoming</creatorcontrib><creatorcontrib>Deng, Liping</creatorcontrib><creatorcontrib>He, Dong</creatorcontrib><creatorcontrib>Cao, Ke</creatorcontrib><collection>MEDLINE - Academic</collection><collection>PubMed Central (Full Participant titles)</collection><jtitle>American journal of cancer research</jtitle></facets><delivery><delcategory>Remote Search Resource</delcategory><fulltext>fulltext</fulltext></delivery><addata><au>Wang, Zhanwang</au><au>Cheng, Yaxin</au><au>Zhu, Yuxing</au><au>Hu, Xueying</au><au>Jin, Yi</au><au>Gong, Lian</au><au>Xiao, Mengqing</au><au>Xiang, Liang</au><au>Zeng, Qinghai</au><au>Liu, Jianye</au><au>Chen, Xingyu</au><au>Zhang, Yeyu</au><au>Liu, Xiaoming</au><au>Deng, Liping</au><au>He, Dong</au><au>Cao, Ke</au><format>journal</format><genre>article</genre><ristype>JOUR</ristype><atitle>Long non-coding RNA FOXD1-AS1 promotes the progression and glycolysis of nasopharyngeal carcinoma by sustaining FOXD1 expression</atitle><jtitle>American journal of cancer research</jtitle><date>2020-01-01</date><risdate>2020</risdate><volume>10</volume><issue>11</issue><spage>3686</spage><epage>3704</epage><pages>3686-3704</pages><issn>2156-6976</issn><eissn>2156-6976</eissn><abstract>Long non-coding RNAs (lncRNAs) play a vital role in the progression of several cancers, including nasopharyngeal carcinoma (NPC). However, the mechanism of lncRNA involvement in the progression of NPC remains to be elucidated. Hence, we conducted in vivo and in vitro experiments to determine the molecular mechanism of FOXD1-AS1. We found that FOXD1-AS1 was over-expressed in NPC cells and tissues, and was significantly associated with poor survival rate in patients with NPC. We also found that FOXD1-AS1 promotes cellular proliferation, migration, invasion, and glycolysis, and inhibits apoptosis by upregulating the expression of FOXD1. Furthermore, FOXD1 could transcriptionally up-regulate the expression of key glycolytic genes to promote the glycolysis levels of NPC. The identified FOXD1-AS1 may serve as a potential prognostic biomarker and therapeutic target for patients with NPC.</abstract><pub>e-Century Publishing Corporation</pub><pmid>33294261</pmid><tpages>19</tpages></addata></record> |
| fulltext | fulltext |
| identifier | ISSN: 2156-6976 |
| ispartof | American journal of cancer research, 2020-01, Vol.10 (11), p.3686-3704 |
| issn | 2156-6976 2156-6976 |
| language | eng |
| recordid | cdi_pubmedcentral_primary_oai_pubmedcentral_nih_gov_7716144 |
| source | Elektronische Zeitschriftenbibliothek - Frei zugängliche E-Journals; PubMed Central |
| subjects | Original |
| title | Long non-coding RNA FOXD1-AS1 promotes the progression and glycolysis of nasopharyngeal carcinoma by sustaining FOXD1 expression |
| url | https://sfx.bib-bvb.de/sfx_tum?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&ctx_tim=2024-12-19T02%3A33%3A18IST&url_ver=Z39.88-2004&url_ctx_fmt=infofi/fmt:kev:mtx:ctx&rfr_id=info:sid/primo.exlibrisgroup.com:primo3-Article-proquest_pubme&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.atitle=Long%20non-coding%20RNA%20FOXD1-AS1%20promotes%20the%20progression%20and%20glycolysis%20of%20nasopharyngeal%20carcinoma%20by%20sustaining%20FOXD1%20expression&rft.jtitle=American%20journal%20of%20cancer%20research&rft.au=Wang,%20Zhanwang&rft.date=2020-01-01&rft.volume=10&rft.issue=11&rft.spage=3686&rft.epage=3704&rft.pages=3686-3704&rft.issn=2156-6976&rft.eissn=2156-6976&rft_id=info:doi/&rft_dat=%3Cproquest_pubme%3E2468660636%3C/proquest_pubme%3E%3Curl%3E%3C/url%3E&disable_directlink=true&sfx.directlink=off&sfx.report_link=0&rft_id=info:oai/&rft_pqid=2468660636&rft_id=info:pmid/33294261&rfr_iscdi=true |