MBRS-65. FBXW7 ACTS A TUMOR SUPPRESSOR IN MYC-DRIVEN MEDULLOBLASTOMA BY CONTROLLING A FEED-FORWARD REGULATORY LOOP OF PLK1 AND MYC

Abstract Group 3 medulloblastoma (MB) is often accompanied by MYC amplification and has a higher rate of metastatic disease. So, it is critical to have more effective therapies for high MYC expressing sub-groups. Here we report that FBXW7, a substrate recognition component of the SKP1-CUL1-Fbox (SCF...

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Veröffentlicht in:	Neuro-oncology (Charlottesville, Va.) Va.), 2020-12, Vol.22 (Supplement_3), p.iii409-iii409
Hauptverfasser:	Wang, Dong, Pierce, Angela, Veo, Bethany, Fosmire, Susan, Madhavan, Krishna, Balakrishnan, Ilango, Venkataraman, Sujatha, Vibhakar, Rajeev
Format:	Artikel
Sprache:	eng
Schlagworte:	Medulloblastoma (Research)
Online-Zugang:	Volltext
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