Mechanism by which TRAF6 Participates in the Immune Regulation of Autoimmune Diseases and Cancer

Tumor necrosis factor (TNF) receptor-associated factor 6 (TRAF6), an E3 ubiquitin ligase, is a signal transduction molecule shared by the interleukin-1 receptor (IL-1R)/Toll-like receptor (TLR) family and the TNFR superfamily. TRAF6 has a unique TRAF domain and RING finger domain that mediate intrac...

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Veröffentlicht in:	BioMed research international 2020, Vol.2020 (2020), p.1-16
Hauptverfasser:	Tai, Guixiang, Jiang, Mengyu, Wu, Xinjie, Wang, Jingjing
Format:	Artikel
Sprache:	eng
Schlagworte:	Adaptive immunity Autoimmune diseases Autoimmune Diseases - metabolism Binding sites Biomedical research Cancer Cellular signal transduction Cytokine receptors Dendritic cells Development and progression Domains Enzymes Etiology Gene expression Genetic aspects Health aspects Homeostasis Humans Immune response Immune system Immunological research Immunoregulation Inflammatory diseases Interleukin 1 Interleukin 1 receptors Intracellular signalling Kinases Lungs Lymphocytes Lymphocytes - immunology Lymphocytes B Lymphocytes T Macrophages Neoplasms - immunology Neoplasms - metabolism Pathogenesis Phosphorylation Physiological aspects Proteasome Endopeptidase Complex - metabolism Proteins Receptors Regulation Review Signal transduction Signaling TNF Receptor-Associated Factor 6 - chemistry TNF Receptor-Associated Factor 6 - genetics TNF Receptor-Associated Factor 6 - metabolism Toll-like receptors TRAF6 protein Transcription factors Tumor necrosis factor Tumor necrosis factor receptors Tumor necrosis factor-TNF Ubiquitin Ubiquitin-protein ligase Ubiquitination
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