Inflammatory Phenotypes Predict Changes in Arterial Stiffness Following Antiretroviral Therapy Initiation

Inflammatory Phenotypes Predict Changes in Arterial Stiffness Following Antiretroviral Therapy Initiation

Abstract Background Inflammation drives vascular dysfunction in HIV, but in low-income settings causes of inflammation are multiple, and include infectious and environmental factors. We hypothesized that patients with advanced immunosuppression could be stratified into inflammatory phenotypes that p...

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Veröffentlicht in:Clinical infectious diseases 2020-12, Vol.71 (9), p.2389-2397
Hauptverfasser: Kelly, Christine, Tinago, Willard, Alber, Dagmar, Hunter, Patricia, Luckhurst, Natasha, Connolly, Jake, Arrigoni, Francesca, Abner, Alejandro Garcia, Kamngona, Ralph, Sheha, Irene, Chammudzi, Mishek, Jambo, Kondwani, Mallewa, Jane, Rapala, Alicja, Heyderman, Robert S, Mallon, Patrick W G, Mwandumba, Henry, Walker, A Sarah, Klein, Nigel, Khoo, Saye
Format: Artikel
Sprache:eng
Schlagworte:
Adult
Biomarkers
CD8-Positive T-Lymphocytes
HIV Infections - complications
HIV Infections - drug therapy
Humans
Major and Commentaries
Phenotype
Vascular Stiffness
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Zusammenfassung:Abstract Background Inflammation drives vascular dysfunction in HIV, but in low-income settings causes of inflammation are multiple, and include infectious and environmental factors. We hypothesized that patients with advanced immunosuppression could be stratified into inflammatory phenotypes that predicted changes in vascular dysfunction on ART. Methods We recruited Malawian adults with CD4
ISSN:1058-4838
1537-6591
DOI:10.1093/cid/ciaa186