Potentially functional genetic variants in KDR gene as prognostic markers in patients with resected colorectal cancer

Angiogenesis plays a key role in the development and treatment response of various tumors. The signaling transductions mediated by the binding of vascular endothelial growth factor (VEGF) to its receptor KDR (kinase insert domain receptor) is the most important pathway in tumor angiogenesis. Single...

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Veröffentlicht in:	Cancer science 2012-03, Vol.103 (3), p.561-568
Hauptverfasser:	Dong, Guanglong, Guo, Xu, Fu, Xiaoying, Wan, Shaogui, Zhou, Feng, Myers, Ronald E., Bao, Guoqiang, Burkart, Ashlie, Yang, Hushan, Xing, Jinliang
Format:	Artikel
Sprache:	eng
Schlagworte:	Adult Aged Aged, 80 and over Angiogenesis Antineoplastic Combined Chemotherapy Protocols - therapeutic use Asian Continental Ancestry Group - genetics Chemotherapy Chemotherapy, Adjuvant Colorectal cancer Colorectal Neoplasms - genetics Colorectal Neoplasms - mortality Colorectal Neoplasms - therapy Digestive System Surgical Procedures Etiology Female Genetic Predisposition to Disease Genotype Humans Kaplan-Meier Estimate KDR gene Male Middle Aged Neoplasm Recurrence, Local - genetics Original Polymorphism, Single Nucleotide Prognosis Promoter Regions, Genetic - genetics Promoters Risk Factors Signal transduction Single-nucleotide polymorphism Tumors Vascular endothelial growth factor Vascular Endothelial Growth Factor Receptor-2 - genetics Young Adult
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